Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy.
Bottom Line: Pretreatment with propranolol and metoprolol improved survival to 90% and 100% respectively, compared with 60% in the ISO group, but did not reduce the incidence and extent of akinesis or the structural damage.TC can be mimicked in a rat model of ISO exposure that demonstrates apical akinesis on days 2 to 3 with full recovery of systolic regional wall motion abnormality despite the presence of persistent foci of necrosis and fibrosis on day 8.Pretreatment with beta-blockers improved survival but did not affect structural and functional alterations.
Affiliation: Heart Institute of Good Samaritan Hospital and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA (J.S., W.D., R.A.K.).Show MeSH
Related in: MedlinePlus
Mentions: The number of surviving animals used for analysis of the data was 9 in each group (Figure 9). In the control group, rats were neither treated with ISO nor beta‐blockers, and showed a 100% survival. In the ISO‐treated group, initially 15 animals were recruited; 6 animals died after ISO administration. The proportion of animals survived was 60%, similar to protocol 1. The percentage of rats that survived 24 hours post‐ISO administration was 90% in the propranolol pretreated group and 100% in the metoprolol pretreated group. Although both beta‐blockers, propanolol and metoprolol, increased survival after ISO injection, significance (P<0.05) was achieved only in the metoprolol pretreated group.
Affiliation: Heart Institute of Good Samaritan Hospital and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA (J.S., W.D., R.A.K.).