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Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy.

Sachdeva J, Dai W, Kloner RA - J Am Heart Assoc (2014)

Bottom Line: Pretreatment with propranolol and metoprolol improved survival to 90% and 100% respectively, compared with 60% in the ISO group, but did not reduce the incidence and extent of akinesis or the structural damage.TC can be mimicked in a rat model of ISO exposure that demonstrates apical akinesis on days 2 to 3 with full recovery of systolic regional wall motion abnormality despite the presence of persistent foci of necrosis and fibrosis on day 8.Pretreatment with beta-blockers improved survival but did not affect structural and functional alterations.

View Article: PubMed Central - PubMed

Affiliation: Heart Institute of Good Samaritan Hospital and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA (J.S., W.D., R.A.K.).

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Flow chart depicting number of animals in each group in Protocol 2. ISO indicates isoproterenol.
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fig09: Flow chart depicting number of animals in each group in Protocol 2. ISO indicates isoproterenol.

Mentions: The number of surviving animals used for analysis of the data was 9 in each group (Figure 9). In the control group, rats were neither treated with ISO nor beta‐blockers, and showed a 100% survival. In the ISO‐treated group, initially 15 animals were recruited; 6 animals died after ISO administration. The proportion of animals survived was 60%, similar to protocol 1. The percentage of rats that survived 24 hours post‐ISO administration was 90% in the propranolol pretreated group and 100% in the metoprolol pretreated group. Although both beta‐blockers, propanolol and metoprolol, increased survival after ISO injection, significance (P<0.05) was achieved only in the metoprolol pretreated group.


Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy.

Sachdeva J, Dai W, Kloner RA - J Am Heart Assoc (2014)

Flow chart depicting number of animals in each group in Protocol 2. ISO indicates isoproterenol.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4309094&req=5

fig09: Flow chart depicting number of animals in each group in Protocol 2. ISO indicates isoproterenol.
Mentions: The number of surviving animals used for analysis of the data was 9 in each group (Figure 9). In the control group, rats were neither treated with ISO nor beta‐blockers, and showed a 100% survival. In the ISO‐treated group, initially 15 animals were recruited; 6 animals died after ISO administration. The proportion of animals survived was 60%, similar to protocol 1. The percentage of rats that survived 24 hours post‐ISO administration was 90% in the propranolol pretreated group and 100% in the metoprolol pretreated group. Although both beta‐blockers, propanolol and metoprolol, increased survival after ISO injection, significance (P<0.05) was achieved only in the metoprolol pretreated group.

Bottom Line: Pretreatment with propranolol and metoprolol improved survival to 90% and 100% respectively, compared with 60% in the ISO group, but did not reduce the incidence and extent of akinesis or the structural damage.TC can be mimicked in a rat model of ISO exposure that demonstrates apical akinesis on days 2 to 3 with full recovery of systolic regional wall motion abnormality despite the presence of persistent foci of necrosis and fibrosis on day 8.Pretreatment with beta-blockers improved survival but did not affect structural and functional alterations.

View Article: PubMed Central - PubMed

Affiliation: Heart Institute of Good Samaritan Hospital and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA (J.S., W.D., R.A.K.).

Show MeSH
Related in: MedlinePlus