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Increasing muscle mass improves vascular function in obese (db/db) mice.

Qiu S, Mintz JD, Salet CD, Han W, Giannis A, Chen F, Yu Y, Su Y, Fulton DJ, Stepp DW - J Am Heart Assoc (2014)

Bottom Line: Inactivity is associated with a loss of muscle mass, which is also reversed with isometric exercise training.This impairment was improved by superoxide dismutase mimic Tempol.This improvement was blunted by nitric oxide (NO) synthase inhibitor l-NG-nitroarginine methyl ester (l-NAME).

View Article: PubMed Central - PubMed

Affiliation: Vascular Biology Center and Department of Physiology, Georgia Regents University, Augusta, GA, Germany (S.Q., J.D.M., C.D.S., W.H., A.G., F.C., Y.Y., Y.S., D.J.F., D.W.S.).

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Forelimb grip strength of all groups of mice (n=5 to 10). *P<0.05; **P<0.01, lean myostatin−/− versus lean or db/db myostatin−/− versus db/db; #P<0.05; ###P<0.001, db/db versus lean or db/db myostatin−/− versus lean myostatin−/−. Data are shown as mean±SEM. db/db myostatin−/− indicates mice lacking both myostatin and leptin receptor; db/db, obese leptin receptor‐deficient mice heterozygous for myostastin; lean myostatin−/−, myostatin‐ mice heterozygous for leptin receptors; lean, lean dual heterozygotes.
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fig04: Forelimb grip strength of all groups of mice (n=5 to 10). *P<0.05; **P<0.01, lean myostatin−/− versus lean or db/db myostatin−/− versus db/db; #P<0.05; ###P<0.001, db/db versus lean or db/db myostatin−/− versus lean myostatin−/−. Data are shown as mean±SEM. db/db myostatin−/− indicates mice lacking both myostatin and leptin receptor; db/db, obese leptin receptor‐deficient mice heterozygous for myostastin; lean myostatin−/−, myostatin‐ mice heterozygous for leptin receptors; lean, lean dual heterozygotes.

Mentions: To determine whether myostatin deletion increases functional as well as physical muscle mass, experiments were performed to assess the strength of myostatin KO mice. Consistent with skeletal muscle phenotype, the peak forelimb grip force of db/db mice was smaller, compared to lean mice (P<0.001), whereas deletion of myostatin in both lean and db/db mice increased peak forelimb grip force (Figure 4; P<0.01, lean vs. lean myostatin−/−; P<0.001, db/db vs. db/db myostatin−/−). It indicates that myostatin deletion not only increases muscle mass, but also improves muscle strength.


Increasing muscle mass improves vascular function in obese (db/db) mice.

Qiu S, Mintz JD, Salet CD, Han W, Giannis A, Chen F, Yu Y, Su Y, Fulton DJ, Stepp DW - J Am Heart Assoc (2014)

Forelimb grip strength of all groups of mice (n=5 to 10). *P<0.05; **P<0.01, lean myostatin−/− versus lean or db/db myostatin−/− versus db/db; #P<0.05; ###P<0.001, db/db versus lean or db/db myostatin−/− versus lean myostatin−/−. Data are shown as mean±SEM. db/db myostatin−/− indicates mice lacking both myostatin and leptin receptor; db/db, obese leptin receptor‐deficient mice heterozygous for myostastin; lean myostatin−/−, myostatin‐ mice heterozygous for leptin receptors; lean, lean dual heterozygotes.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4309080&req=5

fig04: Forelimb grip strength of all groups of mice (n=5 to 10). *P<0.05; **P<0.01, lean myostatin−/− versus lean or db/db myostatin−/− versus db/db; #P<0.05; ###P<0.001, db/db versus lean or db/db myostatin−/− versus lean myostatin−/−. Data are shown as mean±SEM. db/db myostatin−/− indicates mice lacking both myostatin and leptin receptor; db/db, obese leptin receptor‐deficient mice heterozygous for myostastin; lean myostatin−/−, myostatin‐ mice heterozygous for leptin receptors; lean, lean dual heterozygotes.
Mentions: To determine whether myostatin deletion increases functional as well as physical muscle mass, experiments were performed to assess the strength of myostatin KO mice. Consistent with skeletal muscle phenotype, the peak forelimb grip force of db/db mice was smaller, compared to lean mice (P<0.001), whereas deletion of myostatin in both lean and db/db mice increased peak forelimb grip force (Figure 4; P<0.01, lean vs. lean myostatin−/−; P<0.001, db/db vs. db/db myostatin−/−). It indicates that myostatin deletion not only increases muscle mass, but also improves muscle strength.

Bottom Line: Inactivity is associated with a loss of muscle mass, which is also reversed with isometric exercise training.This impairment was improved by superoxide dismutase mimic Tempol.This improvement was blunted by nitric oxide (NO) synthase inhibitor l-NG-nitroarginine methyl ester (l-NAME).

View Article: PubMed Central - PubMed

Affiliation: Vascular Biology Center and Department of Physiology, Georgia Regents University, Augusta, GA, Germany (S.Q., J.D.M., C.D.S., W.H., A.G., F.C., Y.Y., Y.S., D.J.F., D.W.S.).

Show MeSH
Related in: MedlinePlus