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Increasing muscle mass improves vascular function in obese (db/db) mice.

Qiu S, Mintz JD, Salet CD, Han W, Giannis A, Chen F, Yu Y, Su Y, Fulton DJ, Stepp DW - J Am Heart Assoc (2014)

Bottom Line: Inactivity is associated with a loss of muscle mass, which is also reversed with isometric exercise training.This impairment was improved by superoxide dismutase mimic Tempol.This improvement was blunted by nitric oxide (NO) synthase inhibitor l-NG-nitroarginine methyl ester (l-NAME).

View Article: PubMed Central - PubMed

Affiliation: Vascular Biology Center and Department of Physiology, Georgia Regents University, Augusta, GA, Germany (S.Q., J.D.M., C.D.S., W.H., A.G., F.C., Y.Y., Y.S., D.J.F., D.W.S.).

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Body weight was not changed by myoststin deletion. A, Body weight of all 4 groups of genotype at the time of experiment. Twenty‐week‐old male mice were used for measurement. B, Growth curve of all the genotypes. Deletion of myostatin did not have an effect on body weight or weight gain in either lean or obese db/db mice. A and B, Data are shown as mean±SEM (n=8). ###P<0.001, db/db versus lean or db/db myostatin−/− versus lean myostatin−/−. db/db myostatin−/− indicates mice lacking both myostatin and leptin receptor; db/db, obese leptin receptor‐deficient mice heterozygous for myostastin; lean myostatin−/−, myostatin  mice heterozygous for leptin receptors; lean, lean dual heterozygotes.
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fig02: Body weight was not changed by myoststin deletion. A, Body weight of all 4 groups of genotype at the time of experiment. Twenty‐week‐old male mice were used for measurement. B, Growth curve of all the genotypes. Deletion of myostatin did not have an effect on body weight or weight gain in either lean or obese db/db mice. A and B, Data are shown as mean±SEM (n=8). ###P<0.001, db/db versus lean or db/db myostatin−/− versus lean myostatin−/−. db/db myostatin−/− indicates mice lacking both myostatin and leptin receptor; db/db, obese leptin receptor‐deficient mice heterozygous for myostastin; lean myostatin−/−, myostatin mice heterozygous for leptin receptors; lean, lean dual heterozygotes.

Mentions: Figure 2A depicts adult body weight in all 4 genotypes at the time of experimentation. db/db mice were markedly obese, consistent with mutation of the leptin receptor. Deletion of myostatin had no significant effect on adult body weight or the pattern of body‐weight gain (Figure 2B).


Increasing muscle mass improves vascular function in obese (db/db) mice.

Qiu S, Mintz JD, Salet CD, Han W, Giannis A, Chen F, Yu Y, Su Y, Fulton DJ, Stepp DW - J Am Heart Assoc (2014)

Body weight was not changed by myoststin deletion. A, Body weight of all 4 groups of genotype at the time of experiment. Twenty‐week‐old male mice were used for measurement. B, Growth curve of all the genotypes. Deletion of myostatin did not have an effect on body weight or weight gain in either lean or obese db/db mice. A and B, Data are shown as mean±SEM (n=8). ###P<0.001, db/db versus lean or db/db myostatin−/− versus lean myostatin−/−. db/db myostatin−/− indicates mice lacking both myostatin and leptin receptor; db/db, obese leptin receptor‐deficient mice heterozygous for myostastin; lean myostatin−/−, myostatin  mice heterozygous for leptin receptors; lean, lean dual heterozygotes.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4309080&req=5

fig02: Body weight was not changed by myoststin deletion. A, Body weight of all 4 groups of genotype at the time of experiment. Twenty‐week‐old male mice were used for measurement. B, Growth curve of all the genotypes. Deletion of myostatin did not have an effect on body weight or weight gain in either lean or obese db/db mice. A and B, Data are shown as mean±SEM (n=8). ###P<0.001, db/db versus lean or db/db myostatin−/− versus lean myostatin−/−. db/db myostatin−/− indicates mice lacking both myostatin and leptin receptor; db/db, obese leptin receptor‐deficient mice heterozygous for myostastin; lean myostatin−/−, myostatin mice heterozygous for leptin receptors; lean, lean dual heterozygotes.
Mentions: Figure 2A depicts adult body weight in all 4 genotypes at the time of experimentation. db/db mice were markedly obese, consistent with mutation of the leptin receptor. Deletion of myostatin had no significant effect on adult body weight or the pattern of body‐weight gain (Figure 2B).

Bottom Line: Inactivity is associated with a loss of muscle mass, which is also reversed with isometric exercise training.This impairment was improved by superoxide dismutase mimic Tempol.This improvement was blunted by nitric oxide (NO) synthase inhibitor l-NG-nitroarginine methyl ester (l-NAME).

View Article: PubMed Central - PubMed

Affiliation: Vascular Biology Center and Department of Physiology, Georgia Regents University, Augusta, GA, Germany (S.Q., J.D.M., C.D.S., W.H., A.G., F.C., Y.Y., Y.S., D.J.F., D.W.S.).

Show MeSH
Related in: MedlinePlus