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Effect of prolonged stress on the adrenal hormones of individuals with irritable bowel syndrome.

Sugaya N, Izawa S, Saito K, Shirotsuki K, Nomura S, Shimada H - Biopsychosoc Med (2015)

Bottom Line: Regarding cortisol/DHEA ratio, significantly increased levels were found during the first week of the practice, and a significant interaction between group and time was found; the ratio at 30 min after awakening in the IBS group was higher than that in the control group.For the other adrenal hormone indexes, no significant differences due to the presence of IBS were found.The present study suggests that the cortisol effect is dominant in individuals with IBS under prolonged stress.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Public Health, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004 Japan.

ABSTRACT

Background: The purpose of this study was to investigate the effect of prolonged stress on the salivary adrenal hormones (cortisol, dehydroepiandrosterone [DHEA], DHEA-sulfate [DHEA-S]) of individuals with irritable bowel syndrome (IBS).

Methods: The participants were female college students, including 10 with IBS and 16 without IBS (control group), who were scheduled for a 2-week teaching practice at a kindergarten. Participants were asked to collect saliva for determining adrenal hormones immediately and 30 min after awakening and before sleep, 2 weeks before the practice, the first week of the practice, the second week of the practice, and a few days after the practice.

Results: Regarding cortisol/DHEA ratio, significantly increased levels were found during the first week of the practice, and a significant interaction between group and time was found; the ratio at 30 min after awakening in the IBS group was higher than that in the control group. For the other adrenal hormone indexes, no significant differences due to the presence of IBS were found.

Conclusions: Individuals with IBS showed an elevated cortisol/DHEA ratio after awakening compared with individuals without IBS, and the elevated ratio peaked under the prolonged stress. The present study suggests that the cortisol effect is dominant in individuals with IBS under prolonged stress.

No MeSH data available.


Related in: MedlinePlus

Comparison of the transitions of the cortisol/DHEA ratio between the IBS group and the control group. N = 26 (IBS group, 10; control group, 16). Interaction between IBS and time (F [2.00, 231.79] = 6.81, p = 0.001): IBS > Control (30 min after awakening). Effect of day (F [3.00, 241.65] = 3.03, p = 0.03): Day 2 > Day 1. Error bars denote standard errors.
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Fig1: Comparison of the transitions of the cortisol/DHEA ratio between the IBS group and the control group. N = 26 (IBS group, 10; control group, 16). Interaction between IBS and time (F [2.00, 231.79] = 6.81, p = 0.001): IBS > Control (30 min after awakening). Effect of day (F [3.00, 241.65] = 3.03, p = 0.03): Day 2 > Day 1. Error bars denote standard errors.

Mentions: The linear mixed model for cortisol/DHEA ratio showed significant main effects of day (F [3.00, 241.65] = 3.03, p = 0.03) and time (F [2.00, 231.64] = 94.51, p < 0.0001), and a significant interaction between IBS and time (F [2.00, 231.79] = 6.81, p = 0.001) but no significant interactions between IBS and day or among IBS, day, and time (Figure 1).Figure 1


Effect of prolonged stress on the adrenal hormones of individuals with irritable bowel syndrome.

Sugaya N, Izawa S, Saito K, Shirotsuki K, Nomura S, Shimada H - Biopsychosoc Med (2015)

Comparison of the transitions of the cortisol/DHEA ratio between the IBS group and the control group. N = 26 (IBS group, 10; control group, 16). Interaction between IBS and time (F [2.00, 231.79] = 6.81, p = 0.001): IBS > Control (30 min after awakening). Effect of day (F [3.00, 241.65] = 3.03, p = 0.03): Day 2 > Day 1. Error bars denote standard errors.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4308893&req=5

Fig1: Comparison of the transitions of the cortisol/DHEA ratio between the IBS group and the control group. N = 26 (IBS group, 10; control group, 16). Interaction between IBS and time (F [2.00, 231.79] = 6.81, p = 0.001): IBS > Control (30 min after awakening). Effect of day (F [3.00, 241.65] = 3.03, p = 0.03): Day 2 > Day 1. Error bars denote standard errors.
Mentions: The linear mixed model for cortisol/DHEA ratio showed significant main effects of day (F [3.00, 241.65] = 3.03, p = 0.03) and time (F [2.00, 231.64] = 94.51, p < 0.0001), and a significant interaction between IBS and time (F [2.00, 231.79] = 6.81, p = 0.001) but no significant interactions between IBS and day or among IBS, day, and time (Figure 1).Figure 1

Bottom Line: Regarding cortisol/DHEA ratio, significantly increased levels were found during the first week of the practice, and a significant interaction between group and time was found; the ratio at 30 min after awakening in the IBS group was higher than that in the control group.For the other adrenal hormone indexes, no significant differences due to the presence of IBS were found.The present study suggests that the cortisol effect is dominant in individuals with IBS under prolonged stress.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Public Health, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004 Japan.

ABSTRACT

Background: The purpose of this study was to investigate the effect of prolonged stress on the salivary adrenal hormones (cortisol, dehydroepiandrosterone [DHEA], DHEA-sulfate [DHEA-S]) of individuals with irritable bowel syndrome (IBS).

Methods: The participants were female college students, including 10 with IBS and 16 without IBS (control group), who were scheduled for a 2-week teaching practice at a kindergarten. Participants were asked to collect saliva for determining adrenal hormones immediately and 30 min after awakening and before sleep, 2 weeks before the practice, the first week of the practice, the second week of the practice, and a few days after the practice.

Results: Regarding cortisol/DHEA ratio, significantly increased levels were found during the first week of the practice, and a significant interaction between group and time was found; the ratio at 30 min after awakening in the IBS group was higher than that in the control group. For the other adrenal hormone indexes, no significant differences due to the presence of IBS were found.

Conclusions: Individuals with IBS showed an elevated cortisol/DHEA ratio after awakening compared with individuals without IBS, and the elevated ratio peaked under the prolonged stress. The present study suggests that the cortisol effect is dominant in individuals with IBS under prolonged stress.

No MeSH data available.


Related in: MedlinePlus