Limits...
Serum lipids in Brazilian children and adolescents: determining their reference intervals.

Slhessarenko N, Jacob CM, Azevedo RS, Fontes CJ, Novak GV, Andriolo A - BMC Public Health (2015)

Bottom Line: For the LDL-cholesterol, the values corresponding to the percentiles above, aged 1 to 8 years and 9 to 12 years, were 132 mg/dL 139 mg/dL, respectively.For the triglycerides, the values corresponding to 95(th) percentile were: 1 year, 189 mg/dL; 2 to 5 years, 139 mg/dL; 6 to 12 years, 139 mg/dL .The lipid reference intervals defined in the studied Brazilian children and adolescents differ from those recommended by the international literature and should be used for clinical decisions contributing to improve the diagnosis in this particular group in our country.

View Article: PubMed Central - PubMed

Affiliation: Julio Müller School Hospital, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil. ronama@terra.com.br.

ABSTRACT

Background: Demographic, geographic, environmental and genetic factors influence lipids. In many countries, the normal lipid ranges for laboratory tests are based on references from American children and adolescents. In this work, we determined the reference intervals (RIs) for total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), non-high-density lipoprotein cholesterol (nHDL-c), low-density lipoprotein cholesterol (LDL-c) and triglycerides (TG) in Brazilian healthy children and adolescents.

Methods: A cross-sectional study was conducted of 1,866 randomly sampled healthy children and adolescents from kindergartens and schools. Blood samples were collected after a variable period of fasting based on the age of the participant. The upper cut-off points were the 75(th) and 95(th) percentiles for TC, nHDL-c, LDL-c and TG. The 10(th) percentile (low) was used as the bottom level for HDL-c. Non-parametric tests were used for statistical analyses.

Results: The following RI and 75(th) and 95(th) percentiles were observed for each age interval. The 95(th) percentile values obtained for TC were: 1 to 2 years, 189 mg/dL, 3 to 8 years, 199 mg/dL; 9 to 12 years, 205 mg/dL. For the nHDL c, the only age group 1 to 12 years, this percentile value was 150 mg/dL. For the LDL-cholesterol, the values corresponding to the percentiles above, aged 1 to 8 years and 9 to 12 years, were 132 mg/dL 139 mg/dL, respectively. For the triglycerides, the values corresponding to 95(th) percentile were: 1 year, 189 mg/dL; 2 to 5 years, 139 mg/dL; 6 to 12 years, 139 mg/dL . The 10(th) percentiles for HDL-c were 24 mg/dL, 28 mg/dL, 32 mg/dL and 36 mg/dL for children 1, 2, 3 and 4-12 years old, respectively.

Conclusions: The lipid reference intervals defined in the studied Brazilian children and adolescents differ from those recommended by the international literature and should be used for clinical decisions contributing to improve the diagnosis in this particular group in our country.

Show MeSH

Related in: MedlinePlus

Histograms by age group for total cholesterol (mg/dL), after excluding outliers, with coupled Gaussian curves.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4308887&req=5

Fig2: Histograms by age group for total cholesterol (mg/dL), after excluding outliers, with coupled Gaussian curves.

Mentions: The final study population consisted of 1,866 healthy children and adolescents, and 919 (49.2%) were male. Regarding race, 64.4% were declared as mixed race, 19.6% as white, 12.5% as black and 2.8% as Asian descendent. A total of 97% were born in Cuiabá. Their nutritional statuses were classified as 73.4% normal weight, 9.4% overweight, 6.3% at risk of being overweight, 6.9% obese, 2.7% underweight and 1.2% extremely underweight.26 This classification was performed using WHO Anthros and WHO Anthros Plus version 3.2.2. A total of 39.2% of all participants had a family history of diabetes, and 65.5% and 22.4% reported a family history of hypertension and obesity, respectively. Cardiovascular diseases, such as myocardial infarction and stroke, were reported by 17.6% and 12.3%, respectively. Frequency histograms of the serum levels of TC (Figure 2), HDL-c (Figure 3), non-HDL-c (Figure 4), LDL-c (Figure 5) and triglycerides (Figure 6) for all age analyzed for all groups after excluding the outliers are shown in Figures 2, 3, 4, 5, and 6 respectively.Figure 2


Serum lipids in Brazilian children and adolescents: determining their reference intervals.

Slhessarenko N, Jacob CM, Azevedo RS, Fontes CJ, Novak GV, Andriolo A - BMC Public Health (2015)

Histograms by age group for total cholesterol (mg/dL), after excluding outliers, with coupled Gaussian curves.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4308887&req=5

Fig2: Histograms by age group for total cholesterol (mg/dL), after excluding outliers, with coupled Gaussian curves.
Mentions: The final study population consisted of 1,866 healthy children and adolescents, and 919 (49.2%) were male. Regarding race, 64.4% were declared as mixed race, 19.6% as white, 12.5% as black and 2.8% as Asian descendent. A total of 97% were born in Cuiabá. Their nutritional statuses were classified as 73.4% normal weight, 9.4% overweight, 6.3% at risk of being overweight, 6.9% obese, 2.7% underweight and 1.2% extremely underweight.26 This classification was performed using WHO Anthros and WHO Anthros Plus version 3.2.2. A total of 39.2% of all participants had a family history of diabetes, and 65.5% and 22.4% reported a family history of hypertension and obesity, respectively. Cardiovascular diseases, such as myocardial infarction and stroke, were reported by 17.6% and 12.3%, respectively. Frequency histograms of the serum levels of TC (Figure 2), HDL-c (Figure 3), non-HDL-c (Figure 4), LDL-c (Figure 5) and triglycerides (Figure 6) for all age analyzed for all groups after excluding the outliers are shown in Figures 2, 3, 4, 5, and 6 respectively.Figure 2

Bottom Line: For the LDL-cholesterol, the values corresponding to the percentiles above, aged 1 to 8 years and 9 to 12 years, were 132 mg/dL 139 mg/dL, respectively.For the triglycerides, the values corresponding to 95(th) percentile were: 1 year, 189 mg/dL; 2 to 5 years, 139 mg/dL; 6 to 12 years, 139 mg/dL .The lipid reference intervals defined in the studied Brazilian children and adolescents differ from those recommended by the international literature and should be used for clinical decisions contributing to improve the diagnosis in this particular group in our country.

View Article: PubMed Central - PubMed

Affiliation: Julio Müller School Hospital, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil. ronama@terra.com.br.

ABSTRACT

Background: Demographic, geographic, environmental and genetic factors influence lipids. In many countries, the normal lipid ranges for laboratory tests are based on references from American children and adolescents. In this work, we determined the reference intervals (RIs) for total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), non-high-density lipoprotein cholesterol (nHDL-c), low-density lipoprotein cholesterol (LDL-c) and triglycerides (TG) in Brazilian healthy children and adolescents.

Methods: A cross-sectional study was conducted of 1,866 randomly sampled healthy children and adolescents from kindergartens and schools. Blood samples were collected after a variable period of fasting based on the age of the participant. The upper cut-off points were the 75(th) and 95(th) percentiles for TC, nHDL-c, LDL-c and TG. The 10(th) percentile (low) was used as the bottom level for HDL-c. Non-parametric tests were used for statistical analyses.

Results: The following RI and 75(th) and 95(th) percentiles were observed for each age interval. The 95(th) percentile values obtained for TC were: 1 to 2 years, 189 mg/dL, 3 to 8 years, 199 mg/dL; 9 to 12 years, 205 mg/dL. For the nHDL c, the only age group 1 to 12 years, this percentile value was 150 mg/dL. For the LDL-cholesterol, the values corresponding to the percentiles above, aged 1 to 8 years and 9 to 12 years, were 132 mg/dL 139 mg/dL, respectively. For the triglycerides, the values corresponding to 95(th) percentile were: 1 year, 189 mg/dL; 2 to 5 years, 139 mg/dL; 6 to 12 years, 139 mg/dL . The 10(th) percentiles for HDL-c were 24 mg/dL, 28 mg/dL, 32 mg/dL and 36 mg/dL for children 1, 2, 3 and 4-12 years old, respectively.

Conclusions: The lipid reference intervals defined in the studied Brazilian children and adolescents differ from those recommended by the international literature and should be used for clinical decisions contributing to improve the diagnosis in this particular group in our country.

Show MeSH
Related in: MedlinePlus