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MicroRNAs as potential therapeutics for treating spinal cord injury.

Yan H, Hong P, Jiang M, Li H - Neural Regen Res (2012)

Bottom Line: These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration.There are rapidly developing techniques for manipulating microRNA levels in animals; we review different chemical modification and delivery strategies.These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic.

View Article: PubMed Central - PubMed

Affiliation: West China Developmental & Stem Cell Institute, Department of Obstetric & Gynecologic and Pediatric, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China ; West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China.

ABSTRACT
MicroRNAs are a class of recently discovered, small non-coding RNAs that have been shown to play essential roles in a vast majority of biological processes. Very little is known about the role of microRNAs during spinal cord injury. This review summarizes the changes in expression levels of microRNAs after spinal cord injury. These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. Given their small size and specificity of action, microRNAs could be potential therapeutics for treating spinal cord injury in the future. There are rapidly developing techniques for manipulating microRNA levels in animals; we review different chemical modification and delivery strategies. These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic.

No MeSH data available.


Related in: MedlinePlus

Potential miRNA-based interventions at different stages following spinal cord injury (SCI). Distinct miRNAs show changes at different stages after SCI, including during inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. These changes imply that miRNAs may be novel targets for treating SCI.
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Figure 1: Potential miRNA-based interventions at different stages following spinal cord injury (SCI). Distinct miRNAs show changes at different stages after SCI, including during inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. These changes imply that miRNAs may be novel targets for treating SCI.

Mentions: MiRNAs, important gene expression regulators, play essential roles in many biological processes. However, miRNA function during the pathophysiological process of SCI is largely unknown. We summarized the findings of recent publications, mostly involving expression analyses after SCI, implicating the potential functions of these small non-coding RNA molecules in many post-injury processes including inflammation, apoptosis, glial scar formation and axonal regeneration (Figure 1).


MicroRNAs as potential therapeutics for treating spinal cord injury.

Yan H, Hong P, Jiang M, Li H - Neural Regen Res (2012)

Potential miRNA-based interventions at different stages following spinal cord injury (SCI). Distinct miRNAs show changes at different stages after SCI, including during inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. These changes imply that miRNAs may be novel targets for treating SCI.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308808&req=5

Figure 1: Potential miRNA-based interventions at different stages following spinal cord injury (SCI). Distinct miRNAs show changes at different stages after SCI, including during inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. These changes imply that miRNAs may be novel targets for treating SCI.
Mentions: MiRNAs, important gene expression regulators, play essential roles in many biological processes. However, miRNA function during the pathophysiological process of SCI is largely unknown. We summarized the findings of recent publications, mostly involving expression analyses after SCI, implicating the potential functions of these small non-coding RNA molecules in many post-injury processes including inflammation, apoptosis, glial scar formation and axonal regeneration (Figure 1).

Bottom Line: These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration.There are rapidly developing techniques for manipulating microRNA levels in animals; we review different chemical modification and delivery strategies.These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic.

View Article: PubMed Central - PubMed

Affiliation: West China Developmental & Stem Cell Institute, Department of Obstetric & Gynecologic and Pediatric, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China ; West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China.

ABSTRACT
MicroRNAs are a class of recently discovered, small non-coding RNAs that have been shown to play essential roles in a vast majority of biological processes. Very little is known about the role of microRNAs during spinal cord injury. This review summarizes the changes in expression levels of microRNAs after spinal cord injury. These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. Given their small size and specificity of action, microRNAs could be potential therapeutics for treating spinal cord injury in the future. There are rapidly developing techniques for manipulating microRNA levels in animals; we review different chemical modification and delivery strategies. These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic.

No MeSH data available.


Related in: MedlinePlus