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Quantitative assessment of physiological cerebrospinal fluid flow in the cervical spinal canal with 3.0T phase-contrast cine MRI.

Shang H, Liu H, Yan L, Lei J, Cui C, Li H - Neural Regen Res (2012)

Bottom Line: The results revealed that the cerebrospinal fluid peak flow velocity and peak flow rate in the systolic phase were significantly greater than those in the diastolic phase at the same level in the subarachnoid space of the cervical spinal canal.The ventral peak flow velocity and peak flow rate were significantly greater than the post-lateral peak flow velocity and flow rate, while there were no differences between left and right post-lateral subarachnoid peak velocity and flow rate.Moreover, there were no significant differences in peak flow velocity and peak flow rate between the systolic and diastolic phases, ventral, right post-lateral or left post-lateral peak flow velocity and peak flow rate at the same level in the subarachnoid space of the cervical spinal canal among different age groups (18-24, 25-34, 35-44, ≥ 45 years).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.

ABSTRACT
A total of 50 healthy volunteers aged between 18 and 54 years underwent phase-contrast cine MRI to assess cerebrospinal fluid flow characteristics in different regions of the vertebral canal. The results revealed that the cerebrospinal fluid peak flow velocity and peak flow rate in the systolic phase were significantly greater than those in the diastolic phase at the same level in the subarachnoid space of the cervical spinal canal. The ventral peak flow velocity and peak flow rate were significantly greater than the post-lateral peak flow velocity and flow rate, while there were no differences between left and right post-lateral subarachnoid peak velocity and flow rate. Moreover, there were no significant differences in peak flow velocity and peak flow rate between the systolic and diastolic phases, ventral, right post-lateral or left post-lateral peak flow velocity and peak flow rate at the same level in the subarachnoid space of the cervical spinal canal among different age groups (18-24, 25-34, 35-44, ≥ 45 years).

No MeSH data available.


Flow waveform of cervical spinal canal cerebrospinal fluid in one cardiac cycle.Each cardiac cycle was divided into 30 phases. Green number 1 represents cerebrospinal fluid flow curves in green region of interest 1 in Figure 3.
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Figure 4: Flow waveform of cervical spinal canal cerebrospinal fluid in one cardiac cycle.Each cardiac cycle was divided into 30 phases. Green number 1 represents cerebrospinal fluid flow curves in green region of interest 1 in Figure 3.

Mentions: The parameters were as follows: repetition time/echo time/number of excitations/flip angle, 12 ms/6.2 ms/1/20°; slice thickness, 3 mm; gap interval, 0 mm; field of view, 16 cm × 16 cm; matrix, 256 × 128. Velocity encoding was set at 20 cm/s. Head to foot was considered as the positive direction, shown as white on the phase plot, while foot to head was considered the negative direction, shown as black on the phase plot. The entire scanning period lasted 10 minutes. Each cardiac cycle was equally divided into 30 phases. PC-MRI scanning images were post-processed to obtain cervical spinal canal real-time flow velocity in one cardiac cycle at C2-3 levels. Briefly, the obtained images were amplified to an appropriate size, and the window width and position were adjusted until the contrast of cervical subarachnoid space and surrounding structure was clearest. Two imaging physicians carefully drew the range of the vertebral canal subarachnoid space using a trackball to include the entire region containing CSF, while excluding regions free of CSF. Real-time CSF flow velocity in every phase of one cardiac cycle and flow waveform during the entire cardiac cycle was obtained following computerized post-processing, and the maximum value was considered as the peak flow velocity (Figures 3, 4). Peak flow rate (mL/s) = peak flow velocity (cm/s) × cervical spinal canal subarachnoid space area (cm2). The cervical spinal canal is triangular, so we divided it into ventral, right and left post-lateral sections, by drawing a horizontal line parallel to the posterior ventral subarachnoid space. The area in front of the line was regarded as the ventral part, and the area behind the line was considered the post-lateral part. Two physicians with imaging experience carefully drew the range of ventral, right and left post-lateral subarachnoid space using a trackball, and CSF flow velocity was obtained in every phase of each cardiac cycle and flow waveform during the entire cardiac cycle (Figures 5, 6). Peak flow rate (mL/s) = peak flow velocity (cm/s) × area of region of interest (cm2).


Quantitative assessment of physiological cerebrospinal fluid flow in the cervical spinal canal with 3.0T phase-contrast cine MRI.

Shang H, Liu H, Yan L, Lei J, Cui C, Li H - Neural Regen Res (2012)

Flow waveform of cervical spinal canal cerebrospinal fluid in one cardiac cycle.Each cardiac cycle was divided into 30 phases. Green number 1 represents cerebrospinal fluid flow curves in green region of interest 1 in Figure 3.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308789&req=5

Figure 4: Flow waveform of cervical spinal canal cerebrospinal fluid in one cardiac cycle.Each cardiac cycle was divided into 30 phases. Green number 1 represents cerebrospinal fluid flow curves in green region of interest 1 in Figure 3.
Mentions: The parameters were as follows: repetition time/echo time/number of excitations/flip angle, 12 ms/6.2 ms/1/20°; slice thickness, 3 mm; gap interval, 0 mm; field of view, 16 cm × 16 cm; matrix, 256 × 128. Velocity encoding was set at 20 cm/s. Head to foot was considered as the positive direction, shown as white on the phase plot, while foot to head was considered the negative direction, shown as black on the phase plot. The entire scanning period lasted 10 minutes. Each cardiac cycle was equally divided into 30 phases. PC-MRI scanning images were post-processed to obtain cervical spinal canal real-time flow velocity in one cardiac cycle at C2-3 levels. Briefly, the obtained images were amplified to an appropriate size, and the window width and position were adjusted until the contrast of cervical subarachnoid space and surrounding structure was clearest. Two imaging physicians carefully drew the range of the vertebral canal subarachnoid space using a trackball to include the entire region containing CSF, while excluding regions free of CSF. Real-time CSF flow velocity in every phase of one cardiac cycle and flow waveform during the entire cardiac cycle was obtained following computerized post-processing, and the maximum value was considered as the peak flow velocity (Figures 3, 4). Peak flow rate (mL/s) = peak flow velocity (cm/s) × cervical spinal canal subarachnoid space area (cm2). The cervical spinal canal is triangular, so we divided it into ventral, right and left post-lateral sections, by drawing a horizontal line parallel to the posterior ventral subarachnoid space. The area in front of the line was regarded as the ventral part, and the area behind the line was considered the post-lateral part. Two physicians with imaging experience carefully drew the range of ventral, right and left post-lateral subarachnoid space using a trackball, and CSF flow velocity was obtained in every phase of each cardiac cycle and flow waveform during the entire cardiac cycle (Figures 5, 6). Peak flow rate (mL/s) = peak flow velocity (cm/s) × area of region of interest (cm2).

Bottom Line: The results revealed that the cerebrospinal fluid peak flow velocity and peak flow rate in the systolic phase were significantly greater than those in the diastolic phase at the same level in the subarachnoid space of the cervical spinal canal.The ventral peak flow velocity and peak flow rate were significantly greater than the post-lateral peak flow velocity and flow rate, while there were no differences between left and right post-lateral subarachnoid peak velocity and flow rate.Moreover, there were no significant differences in peak flow velocity and peak flow rate between the systolic and diastolic phases, ventral, right post-lateral or left post-lateral peak flow velocity and peak flow rate at the same level in the subarachnoid space of the cervical spinal canal among different age groups (18-24, 25-34, 35-44, ≥ 45 years).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.

ABSTRACT
A total of 50 healthy volunteers aged between 18 and 54 years underwent phase-contrast cine MRI to assess cerebrospinal fluid flow characteristics in different regions of the vertebral canal. The results revealed that the cerebrospinal fluid peak flow velocity and peak flow rate in the systolic phase were significantly greater than those in the diastolic phase at the same level in the subarachnoid space of the cervical spinal canal. The ventral peak flow velocity and peak flow rate were significantly greater than the post-lateral peak flow velocity and flow rate, while there were no differences between left and right post-lateral subarachnoid peak velocity and flow rate. Moreover, there were no significant differences in peak flow velocity and peak flow rate between the systolic and diastolic phases, ventral, right post-lateral or left post-lateral peak flow velocity and peak flow rate at the same level in the subarachnoid space of the cervical spinal canal among different age groups (18-24, 25-34, 35-44, ≥ 45 years).

No MeSH data available.