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Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users.

Hu W, Fu X, Qian R, Wei X, Ji X, Niu C - Neural Regen Res (2012)

Bottom Line: The default mode network is associated with senior cognitive functions in humans.Results showed that the default mode network was significantly activated in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users, and an enhanced activation signal was observed in the right inferior parietal lobule (P < 0.05, corrected for false discovery rate).Experimental findings indicate that the default mode network is altered in heroin users.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, Anhui Province, China.

ABSTRACT
The default mode network is associated with senior cognitive functions in humans. In this study, we performed independent component analysis of blood oxygenation signals from 14 heroin users and 13 matched normal controls in the resting state through functional MRI scans. Results showed that the default mode network was significantly activated in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users, and an enhanced activation signal was observed in the right inferior parietal lobule (P < 0.05, corrected for false discovery rate). Experimental findings indicate that the default mode network is altered in heroin users.

No MeSH data available.


Related in: MedlinePlus

Default mode network of heroin users and normal controls.Different colors represent varying degrees of activation. A cold color means negative activation while a warm color means positive activation.(A) Normal controls showed activation in the prefrontal cortex, posterior cingulated cortex, precuneus, lateral parietal lobe and medial temporal cortices.(B) Heroin users showed activation in the prefrontal cortex, posterior cingulated cortex, precuneus, lateral parietal lobe and medial temporal cortices.
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Figure 1: Default mode network of heroin users and normal controls.Different colors represent varying degrees of activation. A cold color means negative activation while a warm color means positive activation.(A) Normal controls showed activation in the prefrontal cortex, posterior cingulated cortex, precuneus, lateral parietal lobe and medial temporal cortices.(B) Heroin users showed activation in the prefrontal cortex, posterior cingulated cortex, precuneus, lateral parietal lobe and medial temporal cortices.

Mentions: In the DMN, both heroin users and normal controls showed activation in the prefrontal cortex, posterior cingulated cortex, precuneus, lateral parietal lobe and medial temporal cortices (P < 0.05, corrected for false discovery rate; Figure 1).


Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users.

Hu W, Fu X, Qian R, Wei X, Ji X, Niu C - Neural Regen Res (2012)

Default mode network of heroin users and normal controls.Different colors represent varying degrees of activation. A cold color means negative activation while a warm color means positive activation.(A) Normal controls showed activation in the prefrontal cortex, posterior cingulated cortex, precuneus, lateral parietal lobe and medial temporal cortices.(B) Heroin users showed activation in the prefrontal cortex, posterior cingulated cortex, precuneus, lateral parietal lobe and medial temporal cortices.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308788&req=5

Figure 1: Default mode network of heroin users and normal controls.Different colors represent varying degrees of activation. A cold color means negative activation while a warm color means positive activation.(A) Normal controls showed activation in the prefrontal cortex, posterior cingulated cortex, precuneus, lateral parietal lobe and medial temporal cortices.(B) Heroin users showed activation in the prefrontal cortex, posterior cingulated cortex, precuneus, lateral parietal lobe and medial temporal cortices.
Mentions: In the DMN, both heroin users and normal controls showed activation in the prefrontal cortex, posterior cingulated cortex, precuneus, lateral parietal lobe and medial temporal cortices (P < 0.05, corrected for false discovery rate; Figure 1).

Bottom Line: The default mode network is associated with senior cognitive functions in humans.Results showed that the default mode network was significantly activated in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users, and an enhanced activation signal was observed in the right inferior parietal lobule (P < 0.05, corrected for false discovery rate).Experimental findings indicate that the default mode network is altered in heroin users.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, Anhui Province, China.

ABSTRACT
The default mode network is associated with senior cognitive functions in humans. In this study, we performed independent component analysis of blood oxygenation signals from 14 heroin users and 13 matched normal controls in the resting state through functional MRI scans. Results showed that the default mode network was significantly activated in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users, and an enhanced activation signal was observed in the right inferior parietal lobule (P < 0.05, corrected for false discovery rate). Experimental findings indicate that the default mode network is altered in heroin users.

No MeSH data available.


Related in: MedlinePlus