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Synaptic plasticity and neural regeneration

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Totally three articles focusing on “effects of electromagnetic radiation on synaptic structures in the CA1 region of rat hippocampus, effects of transcranial magnetic stimulation and rehabilitation training on synaptic structure on the unaffected side of sensorimotor cortex, and effects of environmental enrichment on hippocampal synapses in adolescent offspring of mothers exposed to prenatal stress” are published in three issues... These findings indicate that mobile phone radiation can significantly impair spatial learning and reference memory and induce morphological changes in the hippocampal CA1 region... Very little is known about the effects of transcranial magnetic stimulation and rehabilitation training on pyramidal cell dendrites and synapses of the contralateral, unaffected sensorimotor cortex in a rat model of focal cerebral infarct... The present study was designed to explore the mechanisms underlying improved motor function via transcranial magnetic stimulation and rehabilitation training following cerebral infarction... Results showed that rehabilitation training or transcranial magnetic stimulation alone reduced neurological impairment in rats following cerebral infarction, as well as significantly increased synaptic curvatures and post-synaptic density in the non-injured cerebral hemisphere sensorimotor cortex and narrowed the synapse cleft width... In addition, the percentage of perforated synapses increased... The combination of transcranial magnetic stimulation and rehabilitation resulted in significantly increased total dendritic length, dendritic branching points, and dendritic density in layer V pyramidal cells of the non-injured cerebral hemisphere motor cortex... These results demonstrated that transcranial magnetic stimulation and rehabilitation training altered structural parameters of pyramidal cell dendrites and synapses in the non-injured cerebral hemisphere sensorimotor cortex, thereby improving the ability to compensate for neurological functions in rats following cerebral infarction... Following weaning, the offspring were raised in an enriched environment to establish models of stress + enriched environment... Dendritic spine density and synaptophysin expression were detected in hippocampal neurons using Golgi staining and western blot analysis, respectively... Results showed that enriched environment increased dendritic spine density of apical dendrites in CA1 pyramidal cells and basal dendrites of granular cells in the outer layer of the dentate gyrus... In addition, hippocampal synaptophysin expression increased and the effects of prenatal stress on neuronal dendritic spines were reversed in adolescence.

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Influence of environmental enrichment on hippocampal synapses in adolescent offspring of mothers exposed to prenatal stressNeural Regen Res. 2011;6(5):378–382.
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Figure 3: Influence of environmental enrichment on hippocampal synapses in adolescent offspring of mothers exposed to prenatal stressNeural Regen Res. 2011;6(5):378–382.


Synaptic plasticity and neural regeneration
Influence of environmental enrichment on hippocampal synapses in adolescent offspring of mothers exposed to prenatal stressNeural Regen Res. 2011;6(5):378–382.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308774&req=5

Figure 3: Influence of environmental enrichment on hippocampal synapses in adolescent offspring of mothers exposed to prenatal stressNeural Regen Res. 2011;6(5):378–382.

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Totally three articles focusing on “effects of electromagnetic radiation on synaptic structures in the CA1 region of rat hippocampus, effects of transcranial magnetic stimulation and rehabilitation training on synaptic structure on the unaffected side of sensorimotor cortex, and effects of environmental enrichment on hippocampal synapses in adolescent offspring of mothers exposed to prenatal stress” are published in three issues... These findings indicate that mobile phone radiation can significantly impair spatial learning and reference memory and induce morphological changes in the hippocampal CA1 region... Very little is known about the effects of transcranial magnetic stimulation and rehabilitation training on pyramidal cell dendrites and synapses of the contralateral, unaffected sensorimotor cortex in a rat model of focal cerebral infarct... The present study was designed to explore the mechanisms underlying improved motor function via transcranial magnetic stimulation and rehabilitation training following cerebral infarction... Results showed that rehabilitation training or transcranial magnetic stimulation alone reduced neurological impairment in rats following cerebral infarction, as well as significantly increased synaptic curvatures and post-synaptic density in the non-injured cerebral hemisphere sensorimotor cortex and narrowed the synapse cleft width... In addition, the percentage of perforated synapses increased... The combination of transcranial magnetic stimulation and rehabilitation resulted in significantly increased total dendritic length, dendritic branching points, and dendritic density in layer V pyramidal cells of the non-injured cerebral hemisphere motor cortex... These results demonstrated that transcranial magnetic stimulation and rehabilitation training altered structural parameters of pyramidal cell dendrites and synapses in the non-injured cerebral hemisphere sensorimotor cortex, thereby improving the ability to compensate for neurological functions in rats following cerebral infarction... Following weaning, the offspring were raised in an enriched environment to establish models of stress + enriched environment... Dendritic spine density and synaptophysin expression were detected in hippocampal neurons using Golgi staining and western blot analysis, respectively... Results showed that enriched environment increased dendritic spine density of apical dendrites in CA1 pyramidal cells and basal dendrites of granular cells in the outer layer of the dentate gyrus... In addition, hippocampal synaptophysin expression increased and the effects of prenatal stress on neuronal dendritic spines were reversed in adolescence.

No MeSH data available.