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Chinese medicine active ingredients or monomers increase neuronal synaptic plasticity

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Totally three articles focusing on Schisandra N-butanol extract effects on hippocampal CA1 synaptic morphology and plasticity in ovarectomized mice, as well as catalpol and GBE 50 effects on neuronal synaptic plasticity in the motor cortex following cerebral ischemia were published in three issues... This treatment led to the enhancement of learning, and an increase in hippocampal CA1 synaptic, surface and postsynaptic density... A decrease in the average size of the synaptic active zone was also observed... The content of total flavonoids in an extract of Ginkgo biloba, called GBE50, is 44% by weight... This is significantly greater than that in a standard extract of Ginkgo biloba, designated EGB761... In the place navigation test, the GBE50 group rats did better than EGB761, while similar scores were obtained in the spatial probe test, and in the platform-switched test... In addition, long-term potentiation was significantly enhanced following high-frequency stimulation in the GBE50 and EGB761 groups, compared with the model group... These results demonstrate that GBE50 and EGB761 improved the learning and memory of aging rats... In particular, GBE50 administered at the 60 mg/kg dose exhibited superior effects over EGB761 at the same 60 mg/kg dose.

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Schisandra N-butanol extract improves synaptic morphology and plasticity in ovarectomized miceNeural Regen Res. 2012;7(18):1365–1369.
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Figure 1: Schisandra N-butanol extract improves synaptic morphology and plasticity in ovarectomized miceNeural Regen Res. 2012;7(18):1365–1369.


Chinese medicine active ingredients or monomers increase neuronal synaptic plasticity
Schisandra N-butanol extract improves synaptic morphology and plasticity in ovarectomized miceNeural Regen Res. 2012;7(18):1365–1369.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308768&req=5

Figure 1: Schisandra N-butanol extract improves synaptic morphology and plasticity in ovarectomized miceNeural Regen Res. 2012;7(18):1365–1369.

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Totally three articles focusing on Schisandra N-butanol extract effects on hippocampal CA1 synaptic morphology and plasticity in ovarectomized mice, as well as catalpol and GBE 50 effects on neuronal synaptic plasticity in the motor cortex following cerebral ischemia were published in three issues... This treatment led to the enhancement of learning, and an increase in hippocampal CA1 synaptic, surface and postsynaptic density... A decrease in the average size of the synaptic active zone was also observed... The content of total flavonoids in an extract of Ginkgo biloba, called GBE50, is 44% by weight... This is significantly greater than that in a standard extract of Ginkgo biloba, designated EGB761... In the place navigation test, the GBE50 group rats did better than EGB761, while similar scores were obtained in the spatial probe test, and in the platform-switched test... In addition, long-term potentiation was significantly enhanced following high-frequency stimulation in the GBE50 and EGB761 groups, compared with the model group... These results demonstrate that GBE50 and EGB761 improved the learning and memory of aging rats... In particular, GBE50 administered at the 60 mg/kg dose exhibited superior effects over EGB761 at the same 60 mg/kg dose.

No MeSH data available.