Limits...
Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia.

Chen G, Fu Q, Cao J, Mi W - Neural Regen Res (2012)

Bottom Line: We intraperitoneally injected 10 and 50 mg/kg of propofol for 7 consecutive days to treat a rat model of chronic cerebral ischemia.A low-dose of propofol promoted the expression of brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element binding protein, and cAMP in the hippocampus of aged rats with chronic cerebral ischemia, but a high-dose of propofol inhibited their expression.Results indicated that the protective effect of propofol against cerebral ischemia in aged rats is related to changes in the expression of brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus, and that the cAMP-cAMP responsive element binding protein pathway is involved in the regulatory effect of propofol on brain-derived neurotrophic factor expression.

View Article: PubMed Central - PubMed

Affiliation: Anesthesia and Operation Center, PLA General Hospital, Beijing 100853, China.

ABSTRACT
We intraperitoneally injected 10 and 50 mg/kg of propofol for 7 consecutive days to treat a rat model of chronic cerebral ischemia. A low-dose of propofol promoted the expression of brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element binding protein, and cAMP in the hippocampus of aged rats with chronic cerebral ischemia, but a high-dose of propofol inhibited their expression. Results indicated that the protective effect of propofol against cerebral ischemia in aged rats is related to changes in the expression of brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus, and that the cAMP-cAMP responsive element binding protein pathway is involved in the regulatory effect of propofol on brain-derived neurotrophic factor expression.

No MeSH data available.


Related in: MedlinePlus

cAMP expression in the hippocampus of aged rats (radioimmunoassay).Data are expressed as the mean ± SD of five rats in each group. Intergroup differences were compared using one-way analysis of variance. aP < 0.01, vs. sham-surgery group;bP < 0.05, vs. model group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4308767&req=5

Figure 4: cAMP expression in the hippocampus of aged rats (radioimmunoassay).Data are expressed as the mean ± SD of five rats in each group. Intergroup differences were compared using one-way analysis of variance. aP < 0.01, vs. sham-surgery group;bP < 0.05, vs. model group.

Mentions: Radioimmunoassay showed that hippocampal cAMP expression was significantly increased in the model group when compared with the sham-surgery group (P < 0.01); while compared with the model group, hippocampal cAMP expression was significantly increased in the low-dose propofol group (P < 0.05), but significantly decreased in the high-dose propofol group (P < 0.05; Figure 4).


Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia.

Chen G, Fu Q, Cao J, Mi W - Neural Regen Res (2012)

cAMP expression in the hippocampus of aged rats (radioimmunoassay).Data are expressed as the mean ± SD of five rats in each group. Intergroup differences were compared using one-way analysis of variance. aP < 0.01, vs. sham-surgery group;bP < 0.05, vs. model group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308767&req=5

Figure 4: cAMP expression in the hippocampus of aged rats (radioimmunoassay).Data are expressed as the mean ± SD of five rats in each group. Intergroup differences were compared using one-way analysis of variance. aP < 0.01, vs. sham-surgery group;bP < 0.05, vs. model group.
Mentions: Radioimmunoassay showed that hippocampal cAMP expression was significantly increased in the model group when compared with the sham-surgery group (P < 0.01); while compared with the model group, hippocampal cAMP expression was significantly increased in the low-dose propofol group (P < 0.05), but significantly decreased in the high-dose propofol group (P < 0.05; Figure 4).

Bottom Line: We intraperitoneally injected 10 and 50 mg/kg of propofol for 7 consecutive days to treat a rat model of chronic cerebral ischemia.A low-dose of propofol promoted the expression of brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element binding protein, and cAMP in the hippocampus of aged rats with chronic cerebral ischemia, but a high-dose of propofol inhibited their expression.Results indicated that the protective effect of propofol against cerebral ischemia in aged rats is related to changes in the expression of brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus, and that the cAMP-cAMP responsive element binding protein pathway is involved in the regulatory effect of propofol on brain-derived neurotrophic factor expression.

View Article: PubMed Central - PubMed

Affiliation: Anesthesia and Operation Center, PLA General Hospital, Beijing 100853, China.

ABSTRACT
We intraperitoneally injected 10 and 50 mg/kg of propofol for 7 consecutive days to treat a rat model of chronic cerebral ischemia. A low-dose of propofol promoted the expression of brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element binding protein, and cAMP in the hippocampus of aged rats with chronic cerebral ischemia, but a high-dose of propofol inhibited their expression. Results indicated that the protective effect of propofol against cerebral ischemia in aged rats is related to changes in the expression of brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus, and that the cAMP-cAMP responsive element binding protein pathway is involved in the regulatory effect of propofol on brain-derived neurotrophic factor expression.

No MeSH data available.


Related in: MedlinePlus