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Electroacupuncture stimulation of the brachial plexus trunk on the healthy side promotes brain-derived neurotrophic factor mRNA expression in the ischemic cerebral cortex of a rat model of cerebral ischemia/reperfusion injury.

Guo Z, Wang L - Neural Regen Res (2012)

Bottom Line: A rat model of cerebral ischemia/reperfusion was established by suture occlusion of the left middle cerebral artery.In situ hybridization results showed that the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic rat cerebral cortex increased after cerebral ischemia/ reperfusion injury.At the same time, electroacupuncture stimulation of the healthy brachial plexus truck significantly decreased neurological function scores and alleviated neurological function deficits.

View Article: PubMed Central - PubMed

Affiliation: Department of Special Health Care, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China.

ABSTRACT
A rat model of cerebral ischemia/reperfusion was established by suture occlusion of the left middle cerebral artery. In situ hybridization results showed that the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic rat cerebral cortex increased after cerebral ischemia/ reperfusion injury. Low frequency continuous wave electroacupuncture (frequency 2-6 Hz, current intensity 2 mA) stimulation of the brachial plexus trunk on the healthy (right) side increased the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic cerebral cortex 14 days after cerebral ischemia/reperfusion injury. At the same time, electroacupuncture stimulation of the healthy brachial plexus truck significantly decreased neurological function scores and alleviated neurological function deficits. These findings suggest that electroacupuncture stimulation of the brachial plexus trunk on the healthy (right) side can greatly increase brain-derived neurotrophic factor mRNA expression and improve neurological function.

No MeSH data available.


Related in: MedlinePlus

Brain-derived neurotrophic factor mRNA expression in the ischemic rat cerebral cortex (in situ hybridization, × 400).Brain derived neurotrophic factor mRNA-positive expression appears brown/yellow. After electroacupuncture stimulation of the brachial plexus trunk, brain derived neurotrophic factor mRNA expression in the rat cerebral cortex increased.
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Figure 1: Brain-derived neurotrophic factor mRNA expression in the ischemic rat cerebral cortex (in situ hybridization, × 400).Brain derived neurotrophic factor mRNA-positive expression appears brown/yellow. After electroacupuncture stimulation of the brachial plexus trunk, brain derived neurotrophic factor mRNA expression in the rat cerebral cortex increased.

Mentions: In situ hybridization showed that brain derived neurotrophic factor mRNA expression in the cerebral cortex was lower in the sham surgery group compared with the electroacupuncture and ischemia/reperfusion groups. The number of brain derived neurotrophic factor mRNA-positive cells in the ischemic rat cerebral cortex increased after ischemic injury for 1 hour and reperfusion for 2 hours, and peaked after reperfusion for 2 and 24 hours. Levels recovered to normal following reperfusion for 7 days (P < 0.05). After reperfusion for 6 hours, the number of brain derived neurotrophic factor mRNA-positive cells in the ischemic cerebral cortex in the electroacupuncture group were significantly greater than those in the ischemia/reperfusion group (P < 0.05), peaked after reperfusion for 24 hours, and decreased thereafter until reperfusion for 14 days (Table 2, Figure 1).


Electroacupuncture stimulation of the brachial plexus trunk on the healthy side promotes brain-derived neurotrophic factor mRNA expression in the ischemic cerebral cortex of a rat model of cerebral ischemia/reperfusion injury.

Guo Z, Wang L - Neural Regen Res (2012)

Brain-derived neurotrophic factor mRNA expression in the ischemic rat cerebral cortex (in situ hybridization, × 400).Brain derived neurotrophic factor mRNA-positive expression appears brown/yellow. After electroacupuncture stimulation of the brachial plexus trunk, brain derived neurotrophic factor mRNA expression in the rat cerebral cortex increased.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308763&req=5

Figure 1: Brain-derived neurotrophic factor mRNA expression in the ischemic rat cerebral cortex (in situ hybridization, × 400).Brain derived neurotrophic factor mRNA-positive expression appears brown/yellow. After electroacupuncture stimulation of the brachial plexus trunk, brain derived neurotrophic factor mRNA expression in the rat cerebral cortex increased.
Mentions: In situ hybridization showed that brain derived neurotrophic factor mRNA expression in the cerebral cortex was lower in the sham surgery group compared with the electroacupuncture and ischemia/reperfusion groups. The number of brain derived neurotrophic factor mRNA-positive cells in the ischemic rat cerebral cortex increased after ischemic injury for 1 hour and reperfusion for 2 hours, and peaked after reperfusion for 2 and 24 hours. Levels recovered to normal following reperfusion for 7 days (P < 0.05). After reperfusion for 6 hours, the number of brain derived neurotrophic factor mRNA-positive cells in the ischemic cerebral cortex in the electroacupuncture group were significantly greater than those in the ischemia/reperfusion group (P < 0.05), peaked after reperfusion for 24 hours, and decreased thereafter until reperfusion for 14 days (Table 2, Figure 1).

Bottom Line: A rat model of cerebral ischemia/reperfusion was established by suture occlusion of the left middle cerebral artery.In situ hybridization results showed that the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic rat cerebral cortex increased after cerebral ischemia/ reperfusion injury.At the same time, electroacupuncture stimulation of the healthy brachial plexus truck significantly decreased neurological function scores and alleviated neurological function deficits.

View Article: PubMed Central - PubMed

Affiliation: Department of Special Health Care, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China.

ABSTRACT
A rat model of cerebral ischemia/reperfusion was established by suture occlusion of the left middle cerebral artery. In situ hybridization results showed that the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic rat cerebral cortex increased after cerebral ischemia/ reperfusion injury. Low frequency continuous wave electroacupuncture (frequency 2-6 Hz, current intensity 2 mA) stimulation of the brachial plexus trunk on the healthy (right) side increased the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic cerebral cortex 14 days after cerebral ischemia/reperfusion injury. At the same time, electroacupuncture stimulation of the healthy brachial plexus truck significantly decreased neurological function scores and alleviated neurological function deficits. These findings suggest that electroacupuncture stimulation of the brachial plexus trunk on the healthy (right) side can greatly increase brain-derived neurotrophic factor mRNA expression and improve neurological function.

No MeSH data available.


Related in: MedlinePlus