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Neurodegenerative disease imaging evaluation and neural regeneration

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Totally three articles focusing on “fluorine-18-fluoro-2-deoxy-D-glucose positron emission computed tomography, functional MRI and interictal single-photon emission CT images for evaluation of the disease degree and prognosis in children with epileptic encephalopathy, the abnormal manifestations of cerebral cortex in parkinsonian resting tremor and the effects of long-term anti-epileptic drug treatment on repair of cerebral perfusion abnormalities and reduced epileptiform discharges in idiopathic epilepsy” are published in three issues... We examined a total of 16 children with epileptic encephalopathy using fluo-rine-18-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission computed tomography (PET), magnetic resonance imaging (MRI) and electroencephalography... Children with infantile spasms showed significant mental retardation, severely abnormal electroencephalogram recordings, and bilateral diffuse cerebral cortex hypometabolism with 18F-FDG PET imaging... In cases with Lennox-Gastaut syndrome, 18F-FDG PET showed bilateral diffuse glucose hypometabolism, while MRI showed cortical atrophy, heterotopic gray matter and tuberous sclerosis... MRI in cases with myoclonic encephalopathy demonstrated bilateral frontal and temporal cortical and white matter atrophy and 18F-FDG PET imaging showed bilateral frontal lobe atrophy with reduced bilateral frontal cortex, occipital cortex, temporal cortex and cerebellar glucose uptake... In children who could not be clearly classified, MRI demonstrated cerebral cortical atrophy and 18F-FDG PET exhibited multifocal glucose hypometabolism... Both structural MRI and resting-state functional MRI scans were collected from nine Parkinson's disease patients with right resting tremor, and from eight age-matched normal controls... Regional homogeneity was compared between Parkinson's disease patients and controls... The results revealed that regional homogeneity was increased in several brain regions, including the right precuneus, right superior parietal gyrus, left anterior cingulate cortex, right middle frontal gyrus and right inferior frontal gyrus... Conversely, regional homogeneity was decreased in the cerebellar vermis in Parkinson's disease patients compared with healthy controls... The present study selected 43 cases of idiopathic epilepsy under antiepileptic drug control for an average of 24 months... Comparisons between interictal single-photon emission CT images and long-term electroencephalogram pre- and post-treatment showed that cases of normal single-photon emission CT increased by 48% (12/25) following treatment, with a total number of 15 reduced foci (36%, 15/41).

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Functional MRI of regional homogeneity changes in parkinsonian resting tremorNeural Regen Res. 2011;6(11):811–815.
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Figure 2: Functional MRI of regional homogeneity changes in parkinsonian resting tremorNeural Regen Res. 2011;6(11):811–815.


Neurodegenerative disease imaging evaluation and neural regeneration
Functional MRI of regional homogeneity changes in parkinsonian resting tremorNeural Regen Res. 2011;6(11):811–815.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308757&req=5

Figure 2: Functional MRI of regional homogeneity changes in parkinsonian resting tremorNeural Regen Res. 2011;6(11):811–815.

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Totally three articles focusing on “fluorine-18-fluoro-2-deoxy-D-glucose positron emission computed tomography, functional MRI and interictal single-photon emission CT images for evaluation of the disease degree and prognosis in children with epileptic encephalopathy, the abnormal manifestations of cerebral cortex in parkinsonian resting tremor and the effects of long-term anti-epileptic drug treatment on repair of cerebral perfusion abnormalities and reduced epileptiform discharges in idiopathic epilepsy” are published in three issues... We examined a total of 16 children with epileptic encephalopathy using fluo-rine-18-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission computed tomography (PET), magnetic resonance imaging (MRI) and electroencephalography... Children with infantile spasms showed significant mental retardation, severely abnormal electroencephalogram recordings, and bilateral diffuse cerebral cortex hypometabolism with 18F-FDG PET imaging... In cases with Lennox-Gastaut syndrome, 18F-FDG PET showed bilateral diffuse glucose hypometabolism, while MRI showed cortical atrophy, heterotopic gray matter and tuberous sclerosis... MRI in cases with myoclonic encephalopathy demonstrated bilateral frontal and temporal cortical and white matter atrophy and 18F-FDG PET imaging showed bilateral frontal lobe atrophy with reduced bilateral frontal cortex, occipital cortex, temporal cortex and cerebellar glucose uptake... In children who could not be clearly classified, MRI demonstrated cerebral cortical atrophy and 18F-FDG PET exhibited multifocal glucose hypometabolism... Both structural MRI and resting-state functional MRI scans were collected from nine Parkinson's disease patients with right resting tremor, and from eight age-matched normal controls... Regional homogeneity was compared between Parkinson's disease patients and controls... The results revealed that regional homogeneity was increased in several brain regions, including the right precuneus, right superior parietal gyrus, left anterior cingulate cortex, right middle frontal gyrus and right inferior frontal gyrus... Conversely, regional homogeneity was decreased in the cerebellar vermis in Parkinson's disease patients compared with healthy controls... The present study selected 43 cases of idiopathic epilepsy under antiepileptic drug control for an average of 24 months... Comparisons between interictal single-photon emission CT images and long-term electroencephalogram pre- and post-treatment showed that cases of normal single-photon emission CT increased by 48% (12/25) following treatment, with a total number of 15 reduced foci (36%, 15/41).

No MeSH data available.