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Detection of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome using mismatch negativity.

Wen X, Wang N, Liu J, Yan Z, Xin Z - Neural Regen Res (2012)

Bottom Line: Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment.These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montreal Cognitive Assessment scores.These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head & Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

ABSTRACT
In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups (mild, moderate, severe) according to minimum oxygen saturation, and 35 healthy subjects were examined as controls. Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment. The results revealed that as the disease worsened, the mismatch negativity latency was gradually extended, and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome. Importantly, mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation < 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation > 60 seconds. Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores. These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montreal Cognitive Assessment scores. As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients, the sensitivity of mismatch negativity is 82.93%, the specificity is 73.33%, the accuracy rate is 81.52%, the positive predictive value is 85.00%, the negative predictive value is 70.21%, the positive likelihood ratio is 3, and the negative likelihood ratio is 0.23. These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients.

No MeSH data available.


Related in: MedlinePlus

Mismatch negativity latency was negatively correlated with Montreal Cognitive Assessment scores (r = −0.791, P < 0.01).
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Figure 1: Mismatch negativity latency was negatively correlated with Montreal Cognitive Assessment scores (r = −0.791, P < 0.01).

Mentions: As mismatch negativity latency prolonged, the MoCA scores progressively decreased. Linear regression analysis revealed a statistically significant correlation between mismatch negativity latency and MoCA scores, with a Pearson correlation coefficient r = −0.791, P < 0.01 (Figure 1).


Detection of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome using mismatch negativity.

Wen X, Wang N, Liu J, Yan Z, Xin Z - Neural Regen Res (2012)

Mismatch negativity latency was negatively correlated with Montreal Cognitive Assessment scores (r = −0.791, P < 0.01).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308756&req=5

Figure 1: Mismatch negativity latency was negatively correlated with Montreal Cognitive Assessment scores (r = −0.791, P < 0.01).
Mentions: As mismatch negativity latency prolonged, the MoCA scores progressively decreased. Linear regression analysis revealed a statistically significant correlation between mismatch negativity latency and MoCA scores, with a Pearson correlation coefficient r = −0.791, P < 0.01 (Figure 1).

Bottom Line: Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment.These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montreal Cognitive Assessment scores.These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head & Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

ABSTRACT
In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups (mild, moderate, severe) according to minimum oxygen saturation, and 35 healthy subjects were examined as controls. Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment. The results revealed that as the disease worsened, the mismatch negativity latency was gradually extended, and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome. Importantly, mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation < 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation > 60 seconds. Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores. These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montreal Cognitive Assessment scores. As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients, the sensitivity of mismatch negativity is 82.93%, the specificity is 73.33%, the accuracy rate is 81.52%, the positive predictive value is 85.00%, the negative predictive value is 70.21%, the positive likelihood ratio is 3, and the negative likelihood ratio is 0.23. These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients.

No MeSH data available.


Related in: MedlinePlus