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Preoperative functional MRI localization of language areas in Chinese patients with brain tumors: Validation with intraoperative electrocortical mapping.

Xia H, Huang W, Wu L, Ma H, Wang X, Chen X, Sun S, Jia X - Neural Regen Res (2012)

Bottom Line: Preoperative functional MRI was performed to locate Broca's or Wernicke's area, and the cortex that was essential for language function was determined by electrocortical mapping.Results showed that the sensitivity and specificity of preoperative functional MRI were 80.0% and 85.0% in Broca's area and 66.6% and 85.2% in Wernicke's area, respectively.These experimental findings indicate that functional MRI is an accurate, reliable technique with which to identify the location of Wernicke's area or Broca's area in patients with brain tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China.

ABSTRACT
Ten Chinese patients with brain tumors involving language regions were selected. Preoperative functional MRI was performed to locate Broca's or Wernicke's area, and the cortex that was essential for language function was determined by electrocortical mapping. A site-by-site comparison between functional MRI and electrocortical mapping was performed with the aid of a neuronavigation device. Results showed that the sensitivity and specificity of preoperative functional MRI were 80.0% and 85.0% in Broca's area and 66.6% and 85.2% in Wernicke's area, respectively. These experimental findings indicate that functional MRI is an accurate, reliable technique with which to identify the location of Wernicke's area or Broca's area in patients with brain tumors.

No MeSH data available.


Related in: MedlinePlus

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Mentions: We determined the number of paradigms by the individual variability of the patients. All patients were briefly trained 1 hour before the image scanning. The neurologists verified the patients’ ability to perform the task correctly before and after the image scanning. If the tumor was within Broca's area, patients were asked to perform reciting to activate Broca's area in the stimulated period of the language task. If the tumor was within Wernicke's area, we used the Chinese paragraph comprehension task, acoustic stimulation to activate Wernicke's area; in this task, subjects listened to a story comprising 25 to 30 Chinese words (supplementary Table 1 online). During rest periods, patients were asked to mentally count from 0 to 10 iteratively. A block design with 30-second alternating periods was used. The trace time was 324 seconds (including a 24-second pre-stimulus period excluded from analysis to allow for stabilization of the BOLD signal) (Figure 3).


Preoperative functional MRI localization of language areas in Chinese patients with brain tumors: Validation with intraoperative electrocortical mapping.

Xia H, Huang W, Wu L, Ma H, Wang X, Chen X, Sun S, Jia X - Neural Regen Res (2012)

Tasks for testing. s: Second.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308752&req=5

Figure 3: Tasks for testing. s: Second.
Mentions: We determined the number of paradigms by the individual variability of the patients. All patients were briefly trained 1 hour before the image scanning. The neurologists verified the patients’ ability to perform the task correctly before and after the image scanning. If the tumor was within Broca's area, patients were asked to perform reciting to activate Broca's area in the stimulated period of the language task. If the tumor was within Wernicke's area, we used the Chinese paragraph comprehension task, acoustic stimulation to activate Wernicke's area; in this task, subjects listened to a story comprising 25 to 30 Chinese words (supplementary Table 1 online). During rest periods, patients were asked to mentally count from 0 to 10 iteratively. A block design with 30-second alternating periods was used. The trace time was 324 seconds (including a 24-second pre-stimulus period excluded from analysis to allow for stabilization of the BOLD signal) (Figure 3).

Bottom Line: Preoperative functional MRI was performed to locate Broca's or Wernicke's area, and the cortex that was essential for language function was determined by electrocortical mapping.Results showed that the sensitivity and specificity of preoperative functional MRI were 80.0% and 85.0% in Broca's area and 66.6% and 85.2% in Wernicke's area, respectively.These experimental findings indicate that functional MRI is an accurate, reliable technique with which to identify the location of Wernicke's area or Broca's area in patients with brain tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China.

ABSTRACT
Ten Chinese patients with brain tumors involving language regions were selected. Preoperative functional MRI was performed to locate Broca's or Wernicke's area, and the cortex that was essential for language function was determined by electrocortical mapping. A site-by-site comparison between functional MRI and electrocortical mapping was performed with the aid of a neuronavigation device. Results showed that the sensitivity and specificity of preoperative functional MRI were 80.0% and 85.0% in Broca's area and 66.6% and 85.2% in Wernicke's area, respectively. These experimental findings indicate that functional MRI is an accurate, reliable technique with which to identify the location of Wernicke's area or Broca's area in patients with brain tumors.

No MeSH data available.


Related in: MedlinePlus