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Corneal subbasal nerve fiber regeneration in myopic patients after laser in situ keratomileusis.

Deng S, Wang M, Zhang F, Sun X, Hou W, Guo N - Neural Regen Res (2012)

Bottom Line: Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases.Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months.In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group.

View Article: PubMed Central - PubMed

Affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.

ABSTRACT
A total of 26 myopic patients (52 eyes) underwent laser in situ keratomileusis. In vivo confocal microscopy revealed that most of the regenerated corneal subbasal nerve fibers in the corneal flap originated from the stump of corneal subbasal nerve fibers outside the ablation zone and extended towards the center of the cornea in all patients. Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases. Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months. In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group. The majority of corneal subbasal nerve fiber regeneration occurred from the stump of corneal subbasal nerve fibers outside the corneal flap, and the remaining growth occurred deep within the stroma.

No MeSH data available.


Related in: MedlinePlus

Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the basic fibroblast growth factor (bFGF) and deproteinized extract of calf blood (DECB) groups postoperation (laser in situ keratomileusis group).Numeration data are expressed as the %. Multinomial logistic regression was used for statistical analysis.
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Figure 7: Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the basic fibroblast growth factor (bFGF) and deproteinized extract of calf blood (DECB) groups postoperation (laser in situ keratomileusis group).Numeration data are expressed as the %. Multinomial logistic regression was used for statistical analysis.

Mentions: In the laser in situ keratomileusis group, new fibers in 95% of eyes in the bFGF group and 83.3% of eyes in the DECB group had passed through the incision (score 1) at 1 month after surgery. At 2 months, statistical analysis was not performed because some follow-up cases were lost. The regenerated corneal subbasal nerve fibers were visible in the central 3-mm diameter zone (score 3) in 50% of eyes in the DECB group, which was faster than that of the bFGF group (30%) at 3 months (Figure 7).


Corneal subbasal nerve fiber regeneration in myopic patients after laser in situ keratomileusis.

Deng S, Wang M, Zhang F, Sun X, Hou W, Guo N - Neural Regen Res (2012)

Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the basic fibroblast growth factor (bFGF) and deproteinized extract of calf blood (DECB) groups postoperation (laser in situ keratomileusis group).Numeration data are expressed as the %. Multinomial logistic regression was used for statistical analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308751&req=5

Figure 7: Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the basic fibroblast growth factor (bFGF) and deproteinized extract of calf blood (DECB) groups postoperation (laser in situ keratomileusis group).Numeration data are expressed as the %. Multinomial logistic regression was used for statistical analysis.
Mentions: In the laser in situ keratomileusis group, new fibers in 95% of eyes in the bFGF group and 83.3% of eyes in the DECB group had passed through the incision (score 1) at 1 month after surgery. At 2 months, statistical analysis was not performed because some follow-up cases were lost. The regenerated corneal subbasal nerve fibers were visible in the central 3-mm diameter zone (score 3) in 50% of eyes in the DECB group, which was faster than that of the bFGF group (30%) at 3 months (Figure 7).

Bottom Line: Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases.Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months.In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group.

View Article: PubMed Central - PubMed

Affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.

ABSTRACT
A total of 26 myopic patients (52 eyes) underwent laser in situ keratomileusis. In vivo confocal microscopy revealed that most of the regenerated corneal subbasal nerve fibers in the corneal flap originated from the stump of corneal subbasal nerve fibers outside the ablation zone and extended towards the center of the cornea in all patients. Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases. Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months. In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group. The majority of corneal subbasal nerve fiber regeneration occurred from the stump of corneal subbasal nerve fibers outside the corneal flap, and the remaining growth occurred deep within the stroma.

No MeSH data available.


Related in: MedlinePlus