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Corneal subbasal nerve fiber regeneration in myopic patients after laser in situ keratomileusis.

Deng S, Wang M, Zhang F, Sun X, Hou W, Guo N - Neural Regen Res (2012)

Bottom Line: Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases.Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months.In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group.

View Article: PubMed Central - PubMed

Affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.

ABSTRACT
A total of 26 myopic patients (52 eyes) underwent laser in situ keratomileusis. In vivo confocal microscopy revealed that most of the regenerated corneal subbasal nerve fibers in the corneal flap originated from the stump of corneal subbasal nerve fibers outside the ablation zone and extended towards the center of the cornea in all patients. Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases. Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months. In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group. The majority of corneal subbasal nerve fiber regeneration occurred from the stump of corneal subbasal nerve fibers outside the corneal flap, and the remaining growth occurred deep within the stroma.

No MeSH data available.


Related in: MedlinePlus

Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the basic fibroblast growth factor (bFGF) and deproteinized extract of calf blood (DECB) groups postoperation (sub-bowman keratomileusis group).Numeration data are expressed as a %. Multinomial logistic regression was used for statistical analysis.
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Figure 6: Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the basic fibroblast growth factor (bFGF) and deproteinized extract of calf blood (DECB) groups postoperation (sub-bowman keratomileusis group).Numeration data are expressed as a %. Multinomial logistic regression was used for statistical analysis.

Mentions: In the sub-bowman keratomileusis group, the new fibers were visible in the 3–6 mm circle area (score 2) in 5.9% of eyes from the bFGF group at 1 month after surgery. However, they did not reach the same circle in the DECB group. New fibers in all eyes from the bFGF group were observed in the 3–6 mm circle area (score 2) at 2 months. Simultaneously, new fibers in 16.7% of eyes in the DECB group were detected in the central 3 mm diameter zone (score 3). At 3 months, new fibers with a score of 3 accounted for 50% of eyes in the DECB group, which was more than that in the bFGF group (33.3%) (Figure 6).


Corneal subbasal nerve fiber regeneration in myopic patients after laser in situ keratomileusis.

Deng S, Wang M, Zhang F, Sun X, Hou W, Guo N - Neural Regen Res (2012)

Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the basic fibroblast growth factor (bFGF) and deproteinized extract of calf blood (DECB) groups postoperation (sub-bowman keratomileusis group).Numeration data are expressed as a %. Multinomial logistic regression was used for statistical analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308751&req=5

Figure 6: Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the basic fibroblast growth factor (bFGF) and deproteinized extract of calf blood (DECB) groups postoperation (sub-bowman keratomileusis group).Numeration data are expressed as a %. Multinomial logistic regression was used for statistical analysis.
Mentions: In the sub-bowman keratomileusis group, the new fibers were visible in the 3–6 mm circle area (score 2) in 5.9% of eyes from the bFGF group at 1 month after surgery. However, they did not reach the same circle in the DECB group. New fibers in all eyes from the bFGF group were observed in the 3–6 mm circle area (score 2) at 2 months. Simultaneously, new fibers in 16.7% of eyes in the DECB group were detected in the central 3 mm diameter zone (score 3). At 3 months, new fibers with a score of 3 accounted for 50% of eyes in the DECB group, which was more than that in the bFGF group (33.3%) (Figure 6).

Bottom Line: Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases.Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months.In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group.

View Article: PubMed Central - PubMed

Affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.

ABSTRACT
A total of 26 myopic patients (52 eyes) underwent laser in situ keratomileusis. In vivo confocal microscopy revealed that most of the regenerated corneal subbasal nerve fibers in the corneal flap originated from the stump of corneal subbasal nerve fibers outside the ablation zone and extended towards the center of the cornea in all patients. Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases. Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months. In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group. The majority of corneal subbasal nerve fiber regeneration occurred from the stump of corneal subbasal nerve fibers outside the corneal flap, and the remaining growth occurred deep within the stroma.

No MeSH data available.


Related in: MedlinePlus