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Corneal subbasal nerve fiber regeneration in myopic patients after laser in situ keratomileusis.

Deng S, Wang M, Zhang F, Sun X, Hou W, Guo N - Neural Regen Res (2012)

Bottom Line: Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases.Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months.In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group.

View Article: PubMed Central - PubMed

Affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.

ABSTRACT
A total of 26 myopic patients (52 eyes) underwent laser in situ keratomileusis. In vivo confocal microscopy revealed that most of the regenerated corneal subbasal nerve fibers in the corneal flap originated from the stump of corneal subbasal nerve fibers outside the ablation zone and extended towards the center of the cornea in all patients. Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases. Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months. In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group. The majority of corneal subbasal nerve fiber regeneration occurred from the stump of corneal subbasal nerve fibers outside the corneal flap, and the remaining growth occurred deep within the stroma.

No MeSH data available.


Related in: MedlinePlus

Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the laser in situ keratomileusis group (n = 26) at various time points postoperation.Numeration data are expressed as a %. Multinomial logistic regression was used for statistical analysis.
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Figure 3: Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the laser in situ keratomileusis group (n = 26) at various time points postoperation.Numeration data are expressed as a %. Multinomial logistic regression was used for statistical analysis.

Mentions: At 1 month after surgery, the regenerated fibers derived from the stump of corneal subbasal nerve fibers outside the incision observed in the circle were assigned a score of 1 in 24 eyes (92.3%) from the laser in situ keratomileusis group and in 49 eyes (94.2%) from the sub-bowman keratomileusis group. Meanwhile, corneal subbasal nerve fibers from two eyes (3.8%) in the sub-bowman keratomileusis group had reached the 3–6 mm diameter circle area (scores 2) (Figures 2, 3). These regenerated fibers appeared branchless, tortuous and thin, and were directed towards the center (Figure 4C).


Corneal subbasal nerve fiber regeneration in myopic patients after laser in situ keratomileusis.

Deng S, Wang M, Zhang F, Sun X, Hou W, Guo N - Neural Regen Res (2012)

Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the laser in situ keratomileusis group (n = 26) at various time points postoperation.Numeration data are expressed as a %. Multinomial logistic regression was used for statistical analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308751&req=5

Figure 3: Speed of regenerated corneal subbasal nerve fibers (CSNFs) in the laser in situ keratomileusis group (n = 26) at various time points postoperation.Numeration data are expressed as a %. Multinomial logistic regression was used for statistical analysis.
Mentions: At 1 month after surgery, the regenerated fibers derived from the stump of corneal subbasal nerve fibers outside the incision observed in the circle were assigned a score of 1 in 24 eyes (92.3%) from the laser in situ keratomileusis group and in 49 eyes (94.2%) from the sub-bowman keratomileusis group. Meanwhile, corneal subbasal nerve fibers from two eyes (3.8%) in the sub-bowman keratomileusis group had reached the 3–6 mm diameter circle area (scores 2) (Figures 2, 3). These regenerated fibers appeared branchless, tortuous and thin, and were directed towards the center (Figure 4C).

Bottom Line: Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases.Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months.In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group.

View Article: PubMed Central - PubMed

Affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.

ABSTRACT
A total of 26 myopic patients (52 eyes) underwent laser in situ keratomileusis. In vivo confocal microscopy revealed that most of the regenerated corneal subbasal nerve fibers in the corneal flap originated from the stump of corneal subbasal nerve fibers outside the ablation zone and extended towards the center of the cornea in all patients. Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases. Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months. In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group. The majority of corneal subbasal nerve fiber regeneration occurred from the stump of corneal subbasal nerve fibers outside the corneal flap, and the remaining growth occurred deep within the stroma.

No MeSH data available.


Related in: MedlinePlus