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Corneal subbasal nerve fiber regeneration in myopic patients after laser in situ keratomileusis.

Deng S, Wang M, Zhang F, Sun X, Hou W, Guo N - Neural Regen Res (2012)

Bottom Line: Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases.Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months.In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group.

View Article: PubMed Central - PubMed

Affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.

ABSTRACT
A total of 26 myopic patients (52 eyes) underwent laser in situ keratomileusis. In vivo confocal microscopy revealed that most of the regenerated corneal subbasal nerve fibers in the corneal flap originated from the stump of corneal subbasal nerve fibers outside the ablation zone and extended towards the center of the cornea in all patients. Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases. Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months. In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group. The majority of corneal subbasal nerve fiber regeneration occurred from the stump of corneal subbasal nerve fibers outside the corneal flap, and the remaining growth occurred deep within the stroma.

No MeSH data available.


Related in: MedlinePlus

Demarcation and scoring of the regenerated corneal subbasal nerve fibers.The cornea was divided into four concentric circle areas: the central 3-mm area was scored 3; the circle area of 3–6 mm to the corneal apex was scored 2; the area between the margin of the corneal flap and score 2 was scored 1; the area outside the margin of the flap was scored 0.
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Figure 1: Demarcation and scoring of the regenerated corneal subbasal nerve fibers.The cornea was divided into four concentric circle areas: the central 3-mm area was scored 3; the circle area of 3–6 mm to the corneal apex was scored 2; the area between the margin of the corneal flap and score 2 was scored 1; the area outside the margin of the flap was scored 0.

Mentions: The regenerative capacity of corneal subbasal nerve fibers was scored as follows. The cornea was divided into four concentric circles (Figure 1). A score of 3 was assigned if regenerated corneal subbasal nerve fibers had grown into the central 3-mm diameter area of the cornea. A score of 2 was assigned when they reached the second circle of 3–6 mm to the corneal apex. A score of 1 was assigned if corneal subbasal nerve fibers had just passed through the margin of the corneal flap and not reached the second circled area. Finally, a score of 0 was assigned when no new corneal subbasal nerve fibers were observed in the corneal flap. Scoring of all regenerated corneal subbasal nerve fibers was performed by an investigator blinded to the treatment group.


Corneal subbasal nerve fiber regeneration in myopic patients after laser in situ keratomileusis.

Deng S, Wang M, Zhang F, Sun X, Hou W, Guo N - Neural Regen Res (2012)

Demarcation and scoring of the regenerated corneal subbasal nerve fibers.The cornea was divided into four concentric circle areas: the central 3-mm area was scored 3; the circle area of 3–6 mm to the corneal apex was scored 2; the area between the margin of the corneal flap and score 2 was scored 1; the area outside the margin of the flap was scored 0.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308751&req=5

Figure 1: Demarcation and scoring of the regenerated corneal subbasal nerve fibers.The cornea was divided into four concentric circle areas: the central 3-mm area was scored 3; the circle area of 3–6 mm to the corneal apex was scored 2; the area between the margin of the corneal flap and score 2 was scored 1; the area outside the margin of the flap was scored 0.
Mentions: The regenerative capacity of corneal subbasal nerve fibers was scored as follows. The cornea was divided into four concentric circles (Figure 1). A score of 3 was assigned if regenerated corneal subbasal nerve fibers had grown into the central 3-mm diameter area of the cornea. A score of 2 was assigned when they reached the second circle of 3–6 mm to the corneal apex. A score of 1 was assigned if corneal subbasal nerve fibers had just passed through the margin of the corneal flap and not reached the second circled area. Finally, a score of 0 was assigned when no new corneal subbasal nerve fibers were observed in the corneal flap. Scoring of all regenerated corneal subbasal nerve fibers was performed by an investigator blinded to the treatment group.

Bottom Line: Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases.Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months.In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group.

View Article: PubMed Central - PubMed

Affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.

ABSTRACT
A total of 26 myopic patients (52 eyes) underwent laser in situ keratomileusis. In vivo confocal microscopy revealed that most of the regenerated corneal subbasal nerve fibers in the corneal flap originated from the stump of corneal subbasal nerve fibers outside the ablation zone and extended towards the center of the cornea in all patients. Meanwhile, new fibers were also found to directly regenerate from deep in the stroma in some cases. Approximately 94% of regenerated corneal subbasal nerve fibers (73/78 eyes) regrew vertically into the peripheral central 6-mm circle area 1 month after surgery, 78% (28/36 eyes) grew into the central 3-6 mm area at 2 months, and 23% into the central 3-mm circle area at 3 months. In addition, there was no significant difference in corneal subbasal nerve fiber regenerative capacity between the basic fibroblast growth factor group and the 20% (v/v) deproteinized extract of calf blood group. The majority of corneal subbasal nerve fiber regeneration occurred from the stump of corneal subbasal nerve fibers outside the corneal flap, and the remaining growth occurred deep within the stroma.

No MeSH data available.


Related in: MedlinePlus