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Concurrent radiotherapy and weekly chemotherapy of 5-fluorouracil and platinum agents for postoperative locoregional recurrence of oesophageal squamous cell carcinoma.

Zhang WW, Zhu YJ, Yang H, Wang QX, Wang XH, Xiao WW, Li QQ, Liu MZ, Hu YH - Sci Rep (2015)

Bottom Line: However, treatment compliance was not quite satisfactory, probably due to treatment-related toxicities.Since CCRT with weekly chemotherapy regimens have demonstrated a favorable toxicity profile as well as promising survival in certain types of cancer, we aimed to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly chemotherapy with 5-fluorouracil (5-FU) and platinum agents for patients with postoperative locoregional recurrence of oesophageal squamous cell carcinoma in our center.Our data showed that the present protocol of radiotherapy combined concurrently with weekly chemotherapy of 5-FU and platinum agents was a safe and effective salvage treatment for postoperative locoregional recurrence of oesophageal squamous cell carcinoma.

View Article: PubMed Central - PubMed

Affiliation: 1] State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China [2] Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China [3] Guangdong Esophogeal Cancer Research Institute, Guangzhou, Guangdong, P.R. China.

ABSTRACT
The most optimal management for postoperative locoregional recurrence of oesophageal squamous cell carcinoma is still controversial. Several studies have reported the feasibility and efficacy of concurrent chemoradiotherapy (CCRT), mostly with three-weekly or four-weekly schedule of chemotherapy. However, treatment compliance was not quite satisfactory, probably due to treatment-related toxicities. Since CCRT with weekly chemotherapy regimens have demonstrated a favorable toxicity profile as well as promising survival in certain types of cancer, we aimed to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly chemotherapy with 5-fluorouracil (5-FU) and platinum agents for patients with postoperative locoregional recurrence of oesophageal squamous cell carcinoma in our center. Twenty-seven consecutive patients who were diagnosed with postoperative locoregional recurrence of oesophageal squamous cell carcinoma and received CCRT with weekly chemotherapy of 5-FU and platinum agents were retrospectively analyzed. Our data showed that the present protocol of radiotherapy combined concurrently with weekly chemotherapy of 5-FU and platinum agents was a safe and effective salvage treatment for postoperative locoregional recurrence of oesophageal squamous cell carcinoma.

No MeSH data available.


Related in: MedlinePlus

Overall survival of (a) all patients (n = 27), (b) patients treated with radiotherapy combined concurrently with weekly chemotherapy of cisplatin plus 5-FU (CF group, n = 14) or nedaplatin plus 5-FU (NF group, n = 13), (c) patients achieved complete/partial remission (CR/PR, n = 19) or stable/progressive disease (SD/PD, n = 8), and (d) patients with Eastern Cooperative Oncology Group Performance Status Scale (ECOG PS) of 0–1 (n = 17) or 2 (n = 10).
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f1: Overall survival of (a) all patients (n = 27), (b) patients treated with radiotherapy combined concurrently with weekly chemotherapy of cisplatin plus 5-FU (CF group, n = 14) or nedaplatin plus 5-FU (NF group, n = 13), (c) patients achieved complete/partial remission (CR/PR, n = 19) or stable/progressive disease (SD/PD, n = 8), and (d) patients with Eastern Cooperative Oncology Group Performance Status Scale (ECOG PS) of 0–1 (n = 17) or 2 (n = 10).

Mentions: After treatment completion, 19 (70.4%) patients achieved complete remission (CR) or partial remission (PR) (Table 2). The median follow-up time was 22.4 months (range, 8.4–59.1 months) for all patients. At the time of this analysis, 14 (51.9%) patients died of oesophageal cancer. No treatment-related death occured. Thirteen (48.1%) patients were alive with (n = 11) or without (n = 2) disease. As shown in Figure 1a, the 1-year and 2-year OS for all patients were 88.9% and 60.2%, respectively, with a median survival time of 26.0 months (95% CI, 10.5–41.4 months). The 1-year and 2-year PFS were 66.7% and 33.9%, respectively, with a median PFS time of 16.4 months (95% CI, 13.4–19.4 months). The 1-year and 2-year LRC were 70.4% and 46.1%, respectively.


Concurrent radiotherapy and weekly chemotherapy of 5-fluorouracil and platinum agents for postoperative locoregional recurrence of oesophageal squamous cell carcinoma.

Zhang WW, Zhu YJ, Yang H, Wang QX, Wang XH, Xiao WW, Li QQ, Liu MZ, Hu YH - Sci Rep (2015)

Overall survival of (a) all patients (n = 27), (b) patients treated with radiotherapy combined concurrently with weekly chemotherapy of cisplatin plus 5-FU (CF group, n = 14) or nedaplatin plus 5-FU (NF group, n = 13), (c) patients achieved complete/partial remission (CR/PR, n = 19) or stable/progressive disease (SD/PD, n = 8), and (d) patients with Eastern Cooperative Oncology Group Performance Status Scale (ECOG PS) of 0–1 (n = 17) or 2 (n = 10).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4308707&req=5

f1: Overall survival of (a) all patients (n = 27), (b) patients treated with radiotherapy combined concurrently with weekly chemotherapy of cisplatin plus 5-FU (CF group, n = 14) or nedaplatin plus 5-FU (NF group, n = 13), (c) patients achieved complete/partial remission (CR/PR, n = 19) or stable/progressive disease (SD/PD, n = 8), and (d) patients with Eastern Cooperative Oncology Group Performance Status Scale (ECOG PS) of 0–1 (n = 17) or 2 (n = 10).
Mentions: After treatment completion, 19 (70.4%) patients achieved complete remission (CR) or partial remission (PR) (Table 2). The median follow-up time was 22.4 months (range, 8.4–59.1 months) for all patients. At the time of this analysis, 14 (51.9%) patients died of oesophageal cancer. No treatment-related death occured. Thirteen (48.1%) patients were alive with (n = 11) or without (n = 2) disease. As shown in Figure 1a, the 1-year and 2-year OS for all patients were 88.9% and 60.2%, respectively, with a median survival time of 26.0 months (95% CI, 10.5–41.4 months). The 1-year and 2-year PFS were 66.7% and 33.9%, respectively, with a median PFS time of 16.4 months (95% CI, 13.4–19.4 months). The 1-year and 2-year LRC were 70.4% and 46.1%, respectively.

Bottom Line: However, treatment compliance was not quite satisfactory, probably due to treatment-related toxicities.Since CCRT with weekly chemotherapy regimens have demonstrated a favorable toxicity profile as well as promising survival in certain types of cancer, we aimed to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly chemotherapy with 5-fluorouracil (5-FU) and platinum agents for patients with postoperative locoregional recurrence of oesophageal squamous cell carcinoma in our center.Our data showed that the present protocol of radiotherapy combined concurrently with weekly chemotherapy of 5-FU and platinum agents was a safe and effective salvage treatment for postoperative locoregional recurrence of oesophageal squamous cell carcinoma.

View Article: PubMed Central - PubMed

Affiliation: 1] State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China [2] Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China [3] Guangdong Esophogeal Cancer Research Institute, Guangzhou, Guangdong, P.R. China.

ABSTRACT
The most optimal management for postoperative locoregional recurrence of oesophageal squamous cell carcinoma is still controversial. Several studies have reported the feasibility and efficacy of concurrent chemoradiotherapy (CCRT), mostly with three-weekly or four-weekly schedule of chemotherapy. However, treatment compliance was not quite satisfactory, probably due to treatment-related toxicities. Since CCRT with weekly chemotherapy regimens have demonstrated a favorable toxicity profile as well as promising survival in certain types of cancer, we aimed to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly chemotherapy with 5-fluorouracil (5-FU) and platinum agents for patients with postoperative locoregional recurrence of oesophageal squamous cell carcinoma in our center. Twenty-seven consecutive patients who were diagnosed with postoperative locoregional recurrence of oesophageal squamous cell carcinoma and received CCRT with weekly chemotherapy of 5-FU and platinum agents were retrospectively analyzed. Our data showed that the present protocol of radiotherapy combined concurrently with weekly chemotherapy of 5-FU and platinum agents was a safe and effective salvage treatment for postoperative locoregional recurrence of oesophageal squamous cell carcinoma.

No MeSH data available.


Related in: MedlinePlus