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Kidney stone analysis: "Give me your stone, I will tell you who you are!".

Cloutier J, Villa L, Traxer O, Daudon M - World J Urol (2014)

Bottom Line: Chemical and physical methods are both used for analysis.Physical methods, in counterpart, are becoming more and more used in high-volume laboratories.Here, specific chemical types with their different crystalline phases are shown in connection with their different etiologies involved.

View Article: PubMed Central - PubMed

Affiliation: Urology Department, Tenon University Hospital, 4 rue de la Chine, 75970, Paris Cedex 20, France.

ABSTRACT

Introduction: Stone analysis is an important part in the evaluation of patients having stone disease. This could orientate the physician toward particular etiologies.

Material and methods: Chemical and physical methods are both used for analysis. Unfortunately, chemical methods often are inadequate to analyze accurately urinary calculi and could fail to detect some elements into the stone. Physical methods, in counterpart, are becoming more and more used in high-volume laboratories. The present manuscript will provide a review on analytic methods, and review all the information that should be included into an appropriate morpho-constitutional analysis.

Conclusion: This report can supply an excellent summarization of the stone morphology and give the opportunity to find specific metabolic disorders and different lithogenic process into the same stone. Here, specific chemical types with their different crystalline phases are shown in connection with their different etiologies involved.

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Related in: MedlinePlus

Whewellite stone initiated from a carbapatite Randall’s plaque (arrow)
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Related In: Results  -  Collection


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Fig1: Whewellite stone initiated from a carbapatite Randall’s plaque (arrow)

Mentions: These methods are able to identify non-calcium stones such as cystine, 2,8-dihydroxyadenine, xanthine, uric acid, urates, methyl-1 uric acid, struvite, proteins, lipids or drugs, as well as calcium oxalate (CaOx) and/or calcium phosphate (CaPh) stones. Because stones may remain several months or years in the urinary tract, they contain commonly (94 % in our experience) several components [19]. An accurate identification of minor components with their location in the stone is clinically relevant to assess environmental factors involved or to explain the lithogenic process (for example crystallization of CaOx from a CaPh Randall’s plaque). Moreover, it could highlight marked changes in conditions with outbreak of new lithogenic process such as primary hyperparathyroidism, type 2 mellitus diabetes or urinary tract infection by urea-splitting bacteria (Figs. 1, 2, 3, 4).Fig. 1


Kidney stone analysis: "Give me your stone, I will tell you who you are!".

Cloutier J, Villa L, Traxer O, Daudon M - World J Urol (2014)

Whewellite stone initiated from a carbapatite Randall’s plaque (arrow)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4308647&req=5

Fig1: Whewellite stone initiated from a carbapatite Randall’s plaque (arrow)
Mentions: These methods are able to identify non-calcium stones such as cystine, 2,8-dihydroxyadenine, xanthine, uric acid, urates, methyl-1 uric acid, struvite, proteins, lipids or drugs, as well as calcium oxalate (CaOx) and/or calcium phosphate (CaPh) stones. Because stones may remain several months or years in the urinary tract, they contain commonly (94 % in our experience) several components [19]. An accurate identification of minor components with their location in the stone is clinically relevant to assess environmental factors involved or to explain the lithogenic process (for example crystallization of CaOx from a CaPh Randall’s plaque). Moreover, it could highlight marked changes in conditions with outbreak of new lithogenic process such as primary hyperparathyroidism, type 2 mellitus diabetes or urinary tract infection by urea-splitting bacteria (Figs. 1, 2, 3, 4).Fig. 1

Bottom Line: Chemical and physical methods are both used for analysis.Physical methods, in counterpart, are becoming more and more used in high-volume laboratories.Here, specific chemical types with their different crystalline phases are shown in connection with their different etiologies involved.

View Article: PubMed Central - PubMed

Affiliation: Urology Department, Tenon University Hospital, 4 rue de la Chine, 75970, Paris Cedex 20, France.

ABSTRACT

Introduction: Stone analysis is an important part in the evaluation of patients having stone disease. This could orientate the physician toward particular etiologies.

Material and methods: Chemical and physical methods are both used for analysis. Unfortunately, chemical methods often are inadequate to analyze accurately urinary calculi and could fail to detect some elements into the stone. Physical methods, in counterpart, are becoming more and more used in high-volume laboratories. The present manuscript will provide a review on analytic methods, and review all the information that should be included into an appropriate morpho-constitutional analysis.

Conclusion: This report can supply an excellent summarization of the stone morphology and give the opportunity to find specific metabolic disorders and different lithogenic process into the same stone. Here, specific chemical types with their different crystalline phases are shown in connection with their different etiologies involved.

Show MeSH
Related in: MedlinePlus