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Kidney stone analysis: "Give me your stone, I will tell you who you are!".

Cloutier J, Villa L, Traxer O, Daudon M - World J Urol (2014)

Bottom Line: Stone analysis is an important part in the evaluation of patients having stone disease.Unfortunately, chemical methods often are inadequate to analyze accurately urinary calculi and could fail to detect some elements into the stone.Here, specific chemical types with their different crystalline phases are shown in connection with their different etiologies involved.

View Article: PubMed Central - PubMed

Affiliation: Urology Department, Tenon University Hospital, 4 rue de la Chine, 75970, Paris Cedex 20, France.

ABSTRACT

Introduction: Stone analysis is an important part in the evaluation of patients having stone disease. This could orientate the physician toward particular etiologies.

Material and methods: Chemical and physical methods are both used for analysis. Unfortunately, chemical methods often are inadequate to analyze accurately urinary calculi and could fail to detect some elements into the stone. Physical methods, in counterpart, are becoming more and more used in high-volume laboratories. The present manuscript will provide a review on analytic methods, and review all the information that should be included into an appropriate morpho-constitutional analysis.

Conclusion: This report can supply an excellent summarization of the stone morphology and give the opportunity to find specific metabolic disorders and different lithogenic process into the same stone. Here, specific chemical types with their different crystalline phases are shown in connection with their different etiologies involved.

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Related in: MedlinePlus

COM stones subtype Ic. Top surface. On the left side, the stones are whitish. They came from an infant aged <2 years. Bottom section. Note the very light color in most parts of the stones
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Fig11: COM stones subtype Ic. Top surface. On the left side, the stones are whitish. They came from an infant aged <2 years. Bottom section. Note the very light color in most parts of the stones

Mentions: In contrast, subtype Ic is very light, brown-yellow pale, or even white in children (Fig. 11). It is associated with heavy oxaluria, mainly primary hyperoxaluria type 1 (related to alanine glyoxylate aminotransferase deficiency in hepatocytes), which is the most severe stone disease often responsible for end-stage renal failure, especially when the diagnosis was delayed because stone morphology was not considered [54, 55]. All 92 stones from patients with PH type 1 analyzed in our laboratory had this Ic morphology, which appears to be virtually pathognomonic for the disease. Therefore, this particular morphology of pure COM stones should immediately orient the physician toward this severe disease to allow early introduction of proactive therapeutic strategy.Fig. 11


Kidney stone analysis: "Give me your stone, I will tell you who you are!".

Cloutier J, Villa L, Traxer O, Daudon M - World J Urol (2014)

COM stones subtype Ic. Top surface. On the left side, the stones are whitish. They came from an infant aged <2 years. Bottom section. Note the very light color in most parts of the stones
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4308647&req=5

Fig11: COM stones subtype Ic. Top surface. On the left side, the stones are whitish. They came from an infant aged <2 years. Bottom section. Note the very light color in most parts of the stones
Mentions: In contrast, subtype Ic is very light, brown-yellow pale, or even white in children (Fig. 11). It is associated with heavy oxaluria, mainly primary hyperoxaluria type 1 (related to alanine glyoxylate aminotransferase deficiency in hepatocytes), which is the most severe stone disease often responsible for end-stage renal failure, especially when the diagnosis was delayed because stone morphology was not considered [54, 55]. All 92 stones from patients with PH type 1 analyzed in our laboratory had this Ic morphology, which appears to be virtually pathognomonic for the disease. Therefore, this particular morphology of pure COM stones should immediately orient the physician toward this severe disease to allow early introduction of proactive therapeutic strategy.Fig. 11

Bottom Line: Stone analysis is an important part in the evaluation of patients having stone disease.Unfortunately, chemical methods often are inadequate to analyze accurately urinary calculi and could fail to detect some elements into the stone.Here, specific chemical types with their different crystalline phases are shown in connection with their different etiologies involved.

View Article: PubMed Central - PubMed

Affiliation: Urology Department, Tenon University Hospital, 4 rue de la Chine, 75970, Paris Cedex 20, France.

ABSTRACT

Introduction: Stone analysis is an important part in the evaluation of patients having stone disease. This could orientate the physician toward particular etiologies.

Material and methods: Chemical and physical methods are both used for analysis. Unfortunately, chemical methods often are inadequate to analyze accurately urinary calculi and could fail to detect some elements into the stone. Physical methods, in counterpart, are becoming more and more used in high-volume laboratories. The present manuscript will provide a review on analytic methods, and review all the information that should be included into an appropriate morpho-constitutional analysis.

Conclusion: This report can supply an excellent summarization of the stone morphology and give the opportunity to find specific metabolic disorders and different lithogenic process into the same stone. Here, specific chemical types with their different crystalline phases are shown in connection with their different etiologies involved.

Show MeSH
Related in: MedlinePlus