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Autoimmune encephalopathy and drug refractory seizures with the presence of two autoantibodies specific for the neuronal cell surface.

Al-Ajlan FS, Althobiti A, Baz S, Al-Attas A - Epilepsy Behav Case Rep (2014)

Bottom Line: Our patient was treated for five days with intravenous methylprednisolone (IVMP) and intravenous immunoglobulin (IVIG).After treatment with IVMP and IVIG, our patient showed significant clinical improvement and did not exhibit any seizures during the one-month follow-up period.Here, we report a rare case of an autoimmune encephalopathy and seizures associated with the presence of two surface neuronal autoantibodies.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

ABSTRACT

Background: An increasing number of autoantibodies are being described in epilepsy and other seizure-related disorders. A pathogenic role of autoantibodies in epilepsy has been suggested based on observations of the efficacy of immunotherapy.

Objective: This study aimed to report a new case of autoimmune-mediated encephalopathy and seizures caused by autoantibodies to voltage-gated potassium channels (VGKCs) and voltage-gated calcium channels (VGCCs) (P/Q-type) and the response to immunotherapy.

Design: This study follows a case report design.

Setting: This study was conducted in a tertiary care center.

Patients: Our patient was an eighteen-year-old female with new-onset encephalopathy and refractory seizures.

Intervention: Our patient was treated for five days with intravenous methylprednisolone (IVMP) and intravenous immunoglobulin (IVIG).

Results: After treatment with IVMP and IVIG, our patient showed significant clinical improvement and did not exhibit any seizures during the one-month follow-up period.

Conclusions: Here, we report a rare case of an autoimmune encephalopathy and seizures associated with the presence of two surface neuronal autoantibodies. This report highlights the importance of early diagnosis of autoimmune epilepsy, as early immunomodulating treatments improve the outcome.

No MeSH data available.


Related in: MedlinePlus

MRI image postrecovery from status epilepticus. Axial FLAIR and DWI show resolution of previously seen abnormalities. ADC map and T2-weighted images (not shown) also were normal.
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f0015: MRI image postrecovery from status epilepticus. Axial FLAIR and DWI show resolution of previously seen abnormalities. ADC map and T2-weighted images (not shown) also were normal.


Autoimmune encephalopathy and drug refractory seizures with the presence of two autoantibodies specific for the neuronal cell surface.

Al-Ajlan FS, Althobiti A, Baz S, Al-Attas A - Epilepsy Behav Case Rep (2014)

MRI image postrecovery from status epilepticus. Axial FLAIR and DWI show resolution of previously seen abnormalities. ADC map and T2-weighted images (not shown) also were normal.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4307881&req=5

f0015: MRI image postrecovery from status epilepticus. Axial FLAIR and DWI show resolution of previously seen abnormalities. ADC map and T2-weighted images (not shown) also were normal.
Bottom Line: Our patient was treated for five days with intravenous methylprednisolone (IVMP) and intravenous immunoglobulin (IVIG).After treatment with IVMP and IVIG, our patient showed significant clinical improvement and did not exhibit any seizures during the one-month follow-up period.Here, we report a rare case of an autoimmune encephalopathy and seizures associated with the presence of two surface neuronal autoantibodies.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

ABSTRACT

Background: An increasing number of autoantibodies are being described in epilepsy and other seizure-related disorders. A pathogenic role of autoantibodies in epilepsy has been suggested based on observations of the efficacy of immunotherapy.

Objective: This study aimed to report a new case of autoimmune-mediated encephalopathy and seizures caused by autoantibodies to voltage-gated potassium channels (VGKCs) and voltage-gated calcium channels (VGCCs) (P/Q-type) and the response to immunotherapy.

Design: This study follows a case report design.

Setting: This study was conducted in a tertiary care center.

Patients: Our patient was an eighteen-year-old female with new-onset encephalopathy and refractory seizures.

Intervention: Our patient was treated for five days with intravenous methylprednisolone (IVMP) and intravenous immunoglobulin (IVIG).

Results: After treatment with IVMP and IVIG, our patient showed significant clinical improvement and did not exhibit any seizures during the one-month follow-up period.

Conclusions: Here, we report a rare case of an autoimmune encephalopathy and seizures associated with the presence of two surface neuronal autoantibodies. This report highlights the importance of early diagnosis of autoimmune epilepsy, as early immunomodulating treatments improve the outcome.

No MeSH data available.


Related in: MedlinePlus