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Intracranial Lesions with Low Signal Intensity on T2-weighted MR Images - Review of Pathologies.

Zimny A, Neska-Matuszewska M, Bladowska J, Sąsiadek MJ - Pol J Radiol (2015)

Bottom Line: In this article we presented intracranial pathological substances and lesions with low signal intensity on T2-weighted images.Eight groups of substances were discussed i.e. 1.Gadolinium-based contrast materials, 2. hemoglobin degradation products 3. melanin, 4. mucous- or protein-containing lesions, 5. highly cellular lesions, 6. lesions containing mineral substances such as: calcium, copper and iron, 7. turbulent and rapid blood or CSF flow 8. air-containing spaces.

View Article: PubMed Central - PubMed

Affiliation: Department of General and Interventional Radiology and Neuroradiology, Wrocław Medical University, Wrocław, Poland.

ABSTRACT
In this article we presented intracranial pathological substances and lesions with low signal intensity on T2-weighted images. Eight groups of substances were discussed i.e. 1. Gadolinium-based contrast materials, 2. hemoglobin degradation products 3. melanin, 4. mucous- or protein-containing lesions, 5. highly cellular lesions, 6. lesions containing mineral substances such as: calcium, copper and iron, 7. turbulent and rapid blood or CSF flow 8. air-containing spaces. Appropriate interpretation of signal intensity as well as analysis of lesion location and clinical symptoms enable a correct choice of a further diagnostic algorithm or, in many cases, final diagnosis based exclusively on an MRI examination.

No MeSH data available.


Related in: MedlinePlus

Metastatic melanoma to the right eyeball. Axial T2-weighted image shows low signal characteristic of melanin.
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Related In: Results  -  Collection


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f9-poljradiol-80-40: Metastatic melanoma to the right eyeball. Axial T2-weighted image shows low signal characteristic of melanin.

Mentions: Melanin shows paramagnetic properties and presents as hypointense on T2- and hyperintense on T1-weighted images [1, 6]. Intracranial metastases occur in nearly 40% of patients with malignant melanoma and can be found in any location (Figure 9). Melanomas are highly vascularized metastases that tend to bleed. Intratumoral bleeding may have a very similar appearance to melanin but in contrary to melanin it tends to evolve in time and change signal. It has to be remembered that melanoma can give amelanotic cerebral metastases which strongly resemble other metastatic lesion (hypointense on T1-weighted and hyperintense on T2-weighted imaging) [10]. Primary diffuse meningeal melanomatosis (an aggressive form of primary intracranial melanoma involving mainly leptomeninges) or neurocutaneous melanosis (congenital condition characterized by multiple giant or hairy pigmented nevi and melanin-containing leptomeningeal lesions without evidence of intracranial melanoma) are rare conditions that lead to intracranial accumulation of melanin [1].


Intracranial Lesions with Low Signal Intensity on T2-weighted MR Images - Review of Pathologies.

Zimny A, Neska-Matuszewska M, Bladowska J, Sąsiadek MJ - Pol J Radiol (2015)

Metastatic melanoma to the right eyeball. Axial T2-weighted image shows low signal characteristic of melanin.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4307690&req=5

f9-poljradiol-80-40: Metastatic melanoma to the right eyeball. Axial T2-weighted image shows low signal characteristic of melanin.
Mentions: Melanin shows paramagnetic properties and presents as hypointense on T2- and hyperintense on T1-weighted images [1, 6]. Intracranial metastases occur in nearly 40% of patients with malignant melanoma and can be found in any location (Figure 9). Melanomas are highly vascularized metastases that tend to bleed. Intratumoral bleeding may have a very similar appearance to melanin but in contrary to melanin it tends to evolve in time and change signal. It has to be remembered that melanoma can give amelanotic cerebral metastases which strongly resemble other metastatic lesion (hypointense on T1-weighted and hyperintense on T2-weighted imaging) [10]. Primary diffuse meningeal melanomatosis (an aggressive form of primary intracranial melanoma involving mainly leptomeninges) or neurocutaneous melanosis (congenital condition characterized by multiple giant or hairy pigmented nevi and melanin-containing leptomeningeal lesions without evidence of intracranial melanoma) are rare conditions that lead to intracranial accumulation of melanin [1].

Bottom Line: In this article we presented intracranial pathological substances and lesions with low signal intensity on T2-weighted images.Eight groups of substances were discussed i.e. 1.Gadolinium-based contrast materials, 2. hemoglobin degradation products 3. melanin, 4. mucous- or protein-containing lesions, 5. highly cellular lesions, 6. lesions containing mineral substances such as: calcium, copper and iron, 7. turbulent and rapid blood or CSF flow 8. air-containing spaces.

View Article: PubMed Central - PubMed

Affiliation: Department of General and Interventional Radiology and Neuroradiology, Wrocław Medical University, Wrocław, Poland.

ABSTRACT
In this article we presented intracranial pathological substances and lesions with low signal intensity on T2-weighted images. Eight groups of substances were discussed i.e. 1. Gadolinium-based contrast materials, 2. hemoglobin degradation products 3. melanin, 4. mucous- or protein-containing lesions, 5. highly cellular lesions, 6. lesions containing mineral substances such as: calcium, copper and iron, 7. turbulent and rapid blood or CSF flow 8. air-containing spaces. Appropriate interpretation of signal intensity as well as analysis of lesion location and clinical symptoms enable a correct choice of a further diagnostic algorithm or, in many cases, final diagnosis based exclusively on an MRI examination.

No MeSH data available.


Related in: MedlinePlus