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The effect of systemic amantadine sulfate on malondialdehyde and total thiol levels in rat corneas.

Yalniz-Akkaya Z, Fidanci V, Kilinc A, Burcu A, Uney GO, Ornek F - J Ophthalmic Vis Res (2014 Jul-Sep)

Bottom Line: In control group, median MDA and SH levels were 2.37 (range, 0.92-3.60) and 25.35 (range, 6.30-54.0) nmol/mg, respectively.In amantadine group, median MDA and SH levels were 3.57 (range, 1.25-5.92) and 32.65 (range, 3.30-48.3) nmol/mg, respectively.The difference between this two groups regarding MDA (P = 0.14) and SH (P = 1.0) levels was statistically insignificant.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.

ABSTRACT

Purpose: To evaluate the malondialdehyde (MDA) and total thiol (sulfhydryl, SH) levels in rat corneas after intraperitoneal injection of amantadine sulfate.

Methods: A total of 12 Wistar albino rats were divided into two groups: control group (n = 6) and amantadine group (n = 6). Balanced salt solution (1 mL, 0.9% NaCl, twice/day) was injected into rats in control group. Amantadine sulfate (2 mg/1 mL, twice/day) was injected into rats in amantadine group. In each group, two rats were injected for 1 week, two received injections for 1 month, and two rats received injections for 3 months. The corneas were homogenized and MDA and SH levels were measured spectroflourometrically.

Results: In control group, median MDA and SH levels were 2.37 (range, 0.92-3.60) and 25.35 (range, 6.30-54.0) nmol/mg, respectively. In amantadine group, median MDA and SH levels were 3.57 (range, 1.25-5.92) and 32.65 (range, 3.30-48.3) nmol/mg, respectively. The difference between this two groups regarding MDA (P = 0.14) and SH (P = 1.0) levels was statistically insignificant.

Conclusion: Systemically administered amantadine sulfate seems not to cause MDA and SH imbalance in rat corneas.

No MeSH data available.


Related in: MedlinePlus

Mean malondyaldehyde (MDA) and total thiol (SH) levels.
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Figure 1: Mean malondyaldehyde (MDA) and total thiol (SH) levels.

Mentions: The levels of MDA and SH in the control group and amantadine group are listed in Table 1 and Figure 1. Concerning MDA (P = 0.14) and SH (P = 1.0) levels, the difference between the control group and amantadine group was not statistically significant [Table 1].


The effect of systemic amantadine sulfate on malondialdehyde and total thiol levels in rat corneas.

Yalniz-Akkaya Z, Fidanci V, Kilinc A, Burcu A, Uney GO, Ornek F - J Ophthalmic Vis Res (2014 Jul-Sep)

Mean malondyaldehyde (MDA) and total thiol (SH) levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4307664&req=5

Figure 1: Mean malondyaldehyde (MDA) and total thiol (SH) levels.
Mentions: The levels of MDA and SH in the control group and amantadine group are listed in Table 1 and Figure 1. Concerning MDA (P = 0.14) and SH (P = 1.0) levels, the difference between the control group and amantadine group was not statistically significant [Table 1].

Bottom Line: In control group, median MDA and SH levels were 2.37 (range, 0.92-3.60) and 25.35 (range, 6.30-54.0) nmol/mg, respectively.In amantadine group, median MDA and SH levels were 3.57 (range, 1.25-5.92) and 32.65 (range, 3.30-48.3) nmol/mg, respectively.The difference between this two groups regarding MDA (P = 0.14) and SH (P = 1.0) levels was statistically insignificant.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.

ABSTRACT

Purpose: To evaluate the malondialdehyde (MDA) and total thiol (sulfhydryl, SH) levels in rat corneas after intraperitoneal injection of amantadine sulfate.

Methods: A total of 12 Wistar albino rats were divided into two groups: control group (n = 6) and amantadine group (n = 6). Balanced salt solution (1 mL, 0.9% NaCl, twice/day) was injected into rats in control group. Amantadine sulfate (2 mg/1 mL, twice/day) was injected into rats in amantadine group. In each group, two rats were injected for 1 week, two received injections for 1 month, and two rats received injections for 3 months. The corneas were homogenized and MDA and SH levels were measured spectroflourometrically.

Results: In control group, median MDA and SH levels were 2.37 (range, 0.92-3.60) and 25.35 (range, 6.30-54.0) nmol/mg, respectively. In amantadine group, median MDA and SH levels were 3.57 (range, 1.25-5.92) and 32.65 (range, 3.30-48.3) nmol/mg, respectively. The difference between this two groups regarding MDA (P = 0.14) and SH (P = 1.0) levels was statistically insignificant.

Conclusion: Systemically administered amantadine sulfate seems not to cause MDA and SH imbalance in rat corneas.

No MeSH data available.


Related in: MedlinePlus