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Immunoglobulin concentration in tears of contact lens wearers.

Maurya RP, Bhushan P, Singh VP, Singh MK, Kumar P, Bhatia RP, Singh U - J Ophthalmic Vis Res (2014 Jul-Sep)

Bottom Line: A total of 45 cases including 23 contact lens wearers (43 eyes) and 22 age and sex matched healthy controls having no ocular pathology were studied for immunoglobulins (IgA, IgG, IgM) in their tears by single radial immunodiffusion method.There was a significant rise in total tear IgA (13.17 ± 4.44 mg/dl) in contact lens wearer as compared to controls (8.93 ± 3.79 mg/dl).All cases with IgM in tear were symptomatic.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

ABSTRACT

Purpose: To evaluate changes in the concentration of tear immunoglobulins in contact lens wearers.

Methods: A total of 45 cases including 23 contact lens wearers (43 eyes) and 22 age and sex matched healthy controls having no ocular pathology were studied for immunoglobulins (IgA, IgG, IgM) in their tears by single radial immunodiffusion method.

Results: Most of the cases used soft (56.6%) and semi-soft gas permeable (30.4%) contact lenses. Tear IgM was detected in only 17.4% and tear IgG in 43.6% of contact lens wearers, while in controls IgG was detected in 9.1% but none of the controls had IgM. There was a significant rise in total tear IgA (13.17 ± 4.44 mg/dl) in contact lens wearer as compared to controls (8.93 ± 3.79 mg/dl). Rise of tear IgA was more in symptomatic patients (15.38 ± 5.28 mg/dl) and in those wearing hard (19.73 ± 5.43 mg/dl) and semi-soft contact lenses (13.31 ± 5.43 mg/dl). A significant increase in tear IgA was noticed in subjects wearing lenses for >3 years (15.69 ± 5.39 mg/dl). About 43.4% of lens wearers were symptomatic and 80% of their lenses showed deposits and/or haziness. All cases with IgM in tear were symptomatic.

Conclusion: The relation of immunoglobulin concentration with increasing duration of wear and material of contact lens shows that tear immunoglobulin rise accrues due to mechanical stimulation, hence contact lenses should not be used for a long period and lenses of hard nature should be discouraged. The maintenance, cleaning and deproteinization of the lenses are of high importance to avoid immunostimulation.

No MeSH data available.


Tear IgM and IgG in contact lens wearers and controls.
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Figure 1: Tear IgM and IgG in contact lens wearers and controls.

Mentions: In only four (17.4%) contact lens wearers IgM (13.0 ± 6.0 mg/dl) was detected, whereas there was no IgM detected in 82.6% of cases. In control subjects, no tear IgM was found either [Figure 1]. Correlation of tear IgM with duration of lens wear revealed that out of four cases in which IgM was detected, one patient was wearing lens for <1 year while three patients were wearing contact lenses for >3 years. All four cases were symptomatic and their contact lenses showed deposits.


Immunoglobulin concentration in tears of contact lens wearers.

Maurya RP, Bhushan P, Singh VP, Singh MK, Kumar P, Bhatia RP, Singh U - J Ophthalmic Vis Res (2014 Jul-Sep)

Tear IgM and IgG in contact lens wearers and controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4307655&req=5

Figure 1: Tear IgM and IgG in contact lens wearers and controls.
Mentions: In only four (17.4%) contact lens wearers IgM (13.0 ± 6.0 mg/dl) was detected, whereas there was no IgM detected in 82.6% of cases. In control subjects, no tear IgM was found either [Figure 1]. Correlation of tear IgM with duration of lens wear revealed that out of four cases in which IgM was detected, one patient was wearing lens for <1 year while three patients were wearing contact lenses for >3 years. All four cases were symptomatic and their contact lenses showed deposits.

Bottom Line: A total of 45 cases including 23 contact lens wearers (43 eyes) and 22 age and sex matched healthy controls having no ocular pathology were studied for immunoglobulins (IgA, IgG, IgM) in their tears by single radial immunodiffusion method.There was a significant rise in total tear IgA (13.17 ± 4.44 mg/dl) in contact lens wearer as compared to controls (8.93 ± 3.79 mg/dl).All cases with IgM in tear were symptomatic.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

ABSTRACT

Purpose: To evaluate changes in the concentration of tear immunoglobulins in contact lens wearers.

Methods: A total of 45 cases including 23 contact lens wearers (43 eyes) and 22 age and sex matched healthy controls having no ocular pathology were studied for immunoglobulins (IgA, IgG, IgM) in their tears by single radial immunodiffusion method.

Results: Most of the cases used soft (56.6%) and semi-soft gas permeable (30.4%) contact lenses. Tear IgM was detected in only 17.4% and tear IgG in 43.6% of contact lens wearers, while in controls IgG was detected in 9.1% but none of the controls had IgM. There was a significant rise in total tear IgA (13.17 ± 4.44 mg/dl) in contact lens wearer as compared to controls (8.93 ± 3.79 mg/dl). Rise of tear IgA was more in symptomatic patients (15.38 ± 5.28 mg/dl) and in those wearing hard (19.73 ± 5.43 mg/dl) and semi-soft contact lenses (13.31 ± 5.43 mg/dl). A significant increase in tear IgA was noticed in subjects wearing lenses for >3 years (15.69 ± 5.39 mg/dl). About 43.4% of lens wearers were symptomatic and 80% of their lenses showed deposits and/or haziness. All cases with IgM in tear were symptomatic.

Conclusion: The relation of immunoglobulin concentration with increasing duration of wear and material of contact lens shows that tear immunoglobulin rise accrues due to mechanical stimulation, hence contact lenses should not be used for a long period and lenses of hard nature should be discouraged. The maintenance, cleaning and deproteinization of the lenses are of high importance to avoid immunostimulation.

No MeSH data available.