Limits...
Prevalence of epilepsy in iran: a meta-analysis and systematic review.

Sayehmiri K, Tavan H, Sayehmiri F, Mohammadi I, V Carson K - Iran J Child Neurol (2014)

Bottom Line: Meta-analysis was conducted using a random effect model with the DerSimonian/Laird method.The most common risk factors in order of prevalence were somatic diseases 39% (95%CI 15 to 62), convulsion 38% (95%CI 11 to 65), mental diseases 36% (95%CI 15 to 95) and hereditary development 26% (95%CI 9 to 42).Although this result is much higher than rates in other countries, a declining trend in prevalence over the past decade was also identified.

View Article: PubMed Central - PubMed

Affiliation: Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran ; Departments of Community Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

ABSTRACT

Objective: Epilepsy is one of the most common diseases in Iran contributing to an array of health problems. In light of this, the aim of the present study is to examine the prevalence of epilepsy in Iran through a systematic review and meta-analysis.

Materials & methods: A systematic search of several databases including PubMed, scientific information databases, Google, Google scholar, Elsevier and Scopus was conducted in June 2013. Observational studies were considered for inclusion if they were published in Iranian and examined epilepsy prevalence and/or related risk factors. Meta-analysis was conducted using a random effect model with the DerSimonian/Laird method. Heterogeneity was examined using the Breslow- Day test and inconsistency using the I2 statistic.

Results: A total of 45 studies were identified from the search strategy. Of these, nine published manuscripts with a total of 7,723 participants were included within the review. The pooled prevalence of epilepsy in Iran was estimated to be around 5% (95% confident interval (CI) 2 to 8). For each region the prevalence of epilepsy in central, northern and eastern Iran were 5% (95%CI 2 to 8), 1% (95%CI -1 to 3) and 4% (95%CI 3 to 11) respectively. The most common risk factors in order of prevalence were somatic diseases 39% (95%CI 15 to 62), convulsion 38% (95%CI 11 to 65), mental diseases 36% (95%CI 15 to 95) and hereditary development 26% (95%CI 9 to 42). A meta-regression model identified a declining trend in the prevalence of epilepsy within Iran for the last decade.

Conclusion: Pooled analyses from the nine included publications in this review estimate the prevalence of epilepsy in Iran to be around 5%. Although this result is much higher than rates in other countries, a declining trend in prevalence over the past decade was also identified.

No MeSH data available.


Related in: MedlinePlus

Age distribution of epilepsy in Iran. Each square represents the effect estimates for each individual study. Their confidence interval for epilepsy prevalence is reflected by the size of each square proportional to the weight assigned to each study within the metaanalysis. The diamond represents the overall pooled results)
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4307363&req=5

Figure 6: Age distribution of epilepsy in Iran. Each square represents the effect estimates for each individual study. Their confidence interval for epilepsy prevalence is reflected by the size of each square proportional to the weight assigned to each study within the metaanalysis. The diamond represents the overall pooled results)

Mentions: Table 2 presents percentages of the four risk factors found to cause epilepsy across the nine included studies. The most dangerous risk factor was identified as somatic diseases (39%) whilst hereditary causes were the least common (26%). The prevalence of epilepsy between men and women was found to be similar between genders and across studies. Meta-regression provides one possible reason for the variability observed across the nine studies, with a larger sample size producing higher epilepsy prevalence rates (Figure 4). Moreover, epilepsy distribution across the five definitive regions in Iran (north, south, west, east and central) may also be responsible for the variability observed between results (ES =0.05; 95%CI 0.02 to 0.08; p= .000; Figure 5). Epilepsy recurrence based on age groups are reported in Figure 6, with prevalence estimates of 0.05 (95%CI 0.00 to 0.1; p=0.000) and 0.04 (95CI% 0.01 to 0.08; p= .000) for people less than or equal to 20 years (reported across six studies) and over 20 years of age (reported across three studies) respectively (ES 0.05; 95%CI 0.02 to 0.08; p= 0.033).


Prevalence of epilepsy in iran: a meta-analysis and systematic review.

Sayehmiri K, Tavan H, Sayehmiri F, Mohammadi I, V Carson K - Iran J Child Neurol (2014)

Age distribution of epilepsy in Iran. Each square represents the effect estimates for each individual study. Their confidence interval for epilepsy prevalence is reflected by the size of each square proportional to the weight assigned to each study within the metaanalysis. The diamond represents the overall pooled results)
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4307363&req=5

Figure 6: Age distribution of epilepsy in Iran. Each square represents the effect estimates for each individual study. Their confidence interval for epilepsy prevalence is reflected by the size of each square proportional to the weight assigned to each study within the metaanalysis. The diamond represents the overall pooled results)
Mentions: Table 2 presents percentages of the four risk factors found to cause epilepsy across the nine included studies. The most dangerous risk factor was identified as somatic diseases (39%) whilst hereditary causes were the least common (26%). The prevalence of epilepsy between men and women was found to be similar between genders and across studies. Meta-regression provides one possible reason for the variability observed across the nine studies, with a larger sample size producing higher epilepsy prevalence rates (Figure 4). Moreover, epilepsy distribution across the five definitive regions in Iran (north, south, west, east and central) may also be responsible for the variability observed between results (ES =0.05; 95%CI 0.02 to 0.08; p= .000; Figure 5). Epilepsy recurrence based on age groups are reported in Figure 6, with prevalence estimates of 0.05 (95%CI 0.00 to 0.1; p=0.000) and 0.04 (95CI% 0.01 to 0.08; p= .000) for people less than or equal to 20 years (reported across six studies) and over 20 years of age (reported across three studies) respectively (ES 0.05; 95%CI 0.02 to 0.08; p= 0.033).

Bottom Line: Meta-analysis was conducted using a random effect model with the DerSimonian/Laird method.The most common risk factors in order of prevalence were somatic diseases 39% (95%CI 15 to 62), convulsion 38% (95%CI 11 to 65), mental diseases 36% (95%CI 15 to 95) and hereditary development 26% (95%CI 9 to 42).Although this result is much higher than rates in other countries, a declining trend in prevalence over the past decade was also identified.

View Article: PubMed Central - PubMed

Affiliation: Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran ; Departments of Community Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

ABSTRACT

Objective: Epilepsy is one of the most common diseases in Iran contributing to an array of health problems. In light of this, the aim of the present study is to examine the prevalence of epilepsy in Iran through a systematic review and meta-analysis.

Materials & methods: A systematic search of several databases including PubMed, scientific information databases, Google, Google scholar, Elsevier and Scopus was conducted in June 2013. Observational studies were considered for inclusion if they were published in Iranian and examined epilepsy prevalence and/or related risk factors. Meta-analysis was conducted using a random effect model with the DerSimonian/Laird method. Heterogeneity was examined using the Breslow- Day test and inconsistency using the I2 statistic.

Results: A total of 45 studies were identified from the search strategy. Of these, nine published manuscripts with a total of 7,723 participants were included within the review. The pooled prevalence of epilepsy in Iran was estimated to be around 5% (95% confident interval (CI) 2 to 8). For each region the prevalence of epilepsy in central, northern and eastern Iran were 5% (95%CI 2 to 8), 1% (95%CI -1 to 3) and 4% (95%CI 3 to 11) respectively. The most common risk factors in order of prevalence were somatic diseases 39% (95%CI 15 to 62), convulsion 38% (95%CI 11 to 65), mental diseases 36% (95%CI 15 to 95) and hereditary development 26% (95%CI 9 to 42). A meta-regression model identified a declining trend in the prevalence of epilepsy within Iran for the last decade.

Conclusion: Pooled analyses from the nine included publications in this review estimate the prevalence of epilepsy in Iran to be around 5%. Although this result is much higher than rates in other countries, a declining trend in prevalence over the past decade was also identified.

No MeSH data available.


Related in: MedlinePlus