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Prevalence of epilepsy in iran: a meta-analysis and systematic review.

Sayehmiri K, Tavan H, Sayehmiri F, Mohammadi I, V Carson K - Iran J Child Neurol (2014)

Bottom Line: A total of 45 studies were identified from the search strategy.The most common risk factors in order of prevalence were somatic diseases 39% (95%CI 15 to 62), convulsion 38% (95%CI 11 to 65), mental diseases 36% (95%CI 15 to 95) and hereditary development 26% (95%CI 9 to 42).Although this result is much higher than rates in other countries, a declining trend in prevalence over the past decade was also identified.

View Article: PubMed Central - PubMed

Affiliation: Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran ; Departments of Community Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

ABSTRACT

Objective: Epilepsy is one of the most common diseases in Iran contributing to an array of health problems. In light of this, the aim of the present study is to examine the prevalence of epilepsy in Iran through a systematic review and meta-analysis.

Materials & methods: A systematic search of several databases including PubMed, scientific information databases, Google, Google scholar, Elsevier and Scopus was conducted in June 2013. Observational studies were considered for inclusion if they were published in Iranian and examined epilepsy prevalence and/or related risk factors. Meta-analysis was conducted using a random effect model with the DerSimonian/Laird method. Heterogeneity was examined using the Breslow- Day test and inconsistency using the I2 statistic.

Results: A total of 45 studies were identified from the search strategy. Of these, nine published manuscripts with a total of 7,723 participants were included within the review. The pooled prevalence of epilepsy in Iran was estimated to be around 5% (95% confident interval (CI) 2 to 8). For each region the prevalence of epilepsy in central, northern and eastern Iran were 5% (95%CI 2 to 8), 1% (95%CI -1 to 3) and 4% (95%CI 3 to 11) respectively. The most common risk factors in order of prevalence were somatic diseases 39% (95%CI 15 to 62), convulsion 38% (95%CI 11 to 65), mental diseases 36% (95%CI 15 to 95) and hereditary development 26% (95%CI 9 to 42). A meta-regression model identified a declining trend in the prevalence of epilepsy within Iran for the last decade.

Conclusion: Pooled analyses from the nine included publications in this review estimate the prevalence of epilepsy in Iran to be around 5%. Although this result is much higher than rates in other countries, a declining trend in prevalence over the past decade was also identified.

No MeSH data available.


Related in: MedlinePlus

Decreasing trend of epilepsy prevalence in the period between 2002 and 2010 in Iran
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Figure 3: Decreasing trend of epilepsy prevalence in the period between 2002 and 2010 in Iran

Mentions: Due to the presence of significant heterogeneity (I2= 97.9%), meta-analyses were conducted using the random effects model as depicted in Figure 2. The overall prevalence of epilepsy observed across the nine studies was 0.05 (95%CI 0.02 to 0.08; I2=97.9%; p= 0.004). Among individual studies Tehran was found to have the highest rate of epilepsy (105 per one thousand people) compared to Brigand with the lowest (9 per one thousand people). The prevalence of recurrent epilepsy is shown in Figure 3 with a decreasing trend observed from 2002 to 2010.


Prevalence of epilepsy in iran: a meta-analysis and systematic review.

Sayehmiri K, Tavan H, Sayehmiri F, Mohammadi I, V Carson K - Iran J Child Neurol (2014)

Decreasing trend of epilepsy prevalence in the period between 2002 and 2010 in Iran
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4307363&req=5

Figure 3: Decreasing trend of epilepsy prevalence in the period between 2002 and 2010 in Iran
Mentions: Due to the presence of significant heterogeneity (I2= 97.9%), meta-analyses were conducted using the random effects model as depicted in Figure 2. The overall prevalence of epilepsy observed across the nine studies was 0.05 (95%CI 0.02 to 0.08; I2=97.9%; p= 0.004). Among individual studies Tehran was found to have the highest rate of epilepsy (105 per one thousand people) compared to Brigand with the lowest (9 per one thousand people). The prevalence of recurrent epilepsy is shown in Figure 3 with a decreasing trend observed from 2002 to 2010.

Bottom Line: A total of 45 studies were identified from the search strategy.The most common risk factors in order of prevalence were somatic diseases 39% (95%CI 15 to 62), convulsion 38% (95%CI 11 to 65), mental diseases 36% (95%CI 15 to 95) and hereditary development 26% (95%CI 9 to 42).Although this result is much higher than rates in other countries, a declining trend in prevalence over the past decade was also identified.

View Article: PubMed Central - PubMed

Affiliation: Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran ; Departments of Community Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

ABSTRACT

Objective: Epilepsy is one of the most common diseases in Iran contributing to an array of health problems. In light of this, the aim of the present study is to examine the prevalence of epilepsy in Iran through a systematic review and meta-analysis.

Materials & methods: A systematic search of several databases including PubMed, scientific information databases, Google, Google scholar, Elsevier and Scopus was conducted in June 2013. Observational studies were considered for inclusion if they were published in Iranian and examined epilepsy prevalence and/or related risk factors. Meta-analysis was conducted using a random effect model with the DerSimonian/Laird method. Heterogeneity was examined using the Breslow- Day test and inconsistency using the I2 statistic.

Results: A total of 45 studies were identified from the search strategy. Of these, nine published manuscripts with a total of 7,723 participants were included within the review. The pooled prevalence of epilepsy in Iran was estimated to be around 5% (95% confident interval (CI) 2 to 8). For each region the prevalence of epilepsy in central, northern and eastern Iran were 5% (95%CI 2 to 8), 1% (95%CI -1 to 3) and 4% (95%CI 3 to 11) respectively. The most common risk factors in order of prevalence were somatic diseases 39% (95%CI 15 to 62), convulsion 38% (95%CI 11 to 65), mental diseases 36% (95%CI 15 to 95) and hereditary development 26% (95%CI 9 to 42). A meta-regression model identified a declining trend in the prevalence of epilepsy within Iran for the last decade.

Conclusion: Pooled analyses from the nine included publications in this review estimate the prevalence of epilepsy in Iran to be around 5%. Although this result is much higher than rates in other countries, a declining trend in prevalence over the past decade was also identified.

No MeSH data available.


Related in: MedlinePlus