Limits...
Synthesis and degradation of Schiff bases containing heterocyclic pharmacophore.

Ledeţi I, Alexa A, Bercean V, Vlase G, Vlase T, Şuta LM, Fuliaş A - Int J Mol Sci (2015)

Bottom Line: This paper reports on the synthesis and characterization of two Schiff bases bearing 1,2,4-triazolic moieties, namely 4H-4-(2-hydroxy-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole and 4H-4-(4-nitro-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole using thin layer chromatography, melting interval, elemental analysis, spectroscopy and thermal stability studies.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, Timisoara 300041, Romania. ionut.ledeti@umft.ro.

ABSTRACT
This paper reports on the synthesis and characterization of two Schiff bases bearing 1,2,4-triazolic moieties, namely 4H-4-(2-hydroxy-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole and 4H-4-(4-nitro-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole using thin layer chromatography, melting interval, elemental analysis, spectroscopy and thermal stability studies.

Show MeSH
The thermoanalytical curves (TG/DTG/HF) recorded with β = 15 °C/min for SB2 derivative.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4307329&req=5

ijms-16-01711-f003: The thermoanalytical curves (TG/DTG/HF) recorded with β = 15 °C/min for SB2 derivative.

Mentions: For Schiff base (SB2), the analysis of thermoanalytical curves (Figure 3) reveals a better thermal stability (up to 204 °C). Only the HF curve reveals an endothermic effect at 197.7 °C which is due to the melting and is in good agreement with the melting observed on the Boethius apparatus. TG curve indicates that a two steps degradation of this compound occurs, in 204–273 °C (with a mass loss Δm = 44.44% and with a DTGmax = 247 °C), and in 273–357 °C (with a mass loss Δm = 37.07% and with a DTGmax = 288 °C) temperature ranges, respectively. The HF curve indicates in these temperature ranges two maximums, at 244 and 286 °C which can be associated with thermooxidation processes of molecule destruction.


Synthesis and degradation of Schiff bases containing heterocyclic pharmacophore.

Ledeţi I, Alexa A, Bercean V, Vlase G, Vlase T, Şuta LM, Fuliaş A - Int J Mol Sci (2015)

The thermoanalytical curves (TG/DTG/HF) recorded with β = 15 °C/min for SB2 derivative.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4307329&req=5

ijms-16-01711-f003: The thermoanalytical curves (TG/DTG/HF) recorded with β = 15 °C/min for SB2 derivative.
Mentions: For Schiff base (SB2), the analysis of thermoanalytical curves (Figure 3) reveals a better thermal stability (up to 204 °C). Only the HF curve reveals an endothermic effect at 197.7 °C which is due to the melting and is in good agreement with the melting observed on the Boethius apparatus. TG curve indicates that a two steps degradation of this compound occurs, in 204–273 °C (with a mass loss Δm = 44.44% and with a DTGmax = 247 °C), and in 273–357 °C (with a mass loss Δm = 37.07% and with a DTGmax = 288 °C) temperature ranges, respectively. The HF curve indicates in these temperature ranges two maximums, at 244 and 286 °C which can be associated with thermooxidation processes of molecule destruction.

Bottom Line: This paper reports on the synthesis and characterization of two Schiff bases bearing 1,2,4-triazolic moieties, namely 4H-4-(2-hydroxy-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole and 4H-4-(4-nitro-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole using thin layer chromatography, melting interval, elemental analysis, spectroscopy and thermal stability studies.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, Timisoara 300041, Romania. ionut.ledeti@umft.ro.

ABSTRACT
This paper reports on the synthesis and characterization of two Schiff bases bearing 1,2,4-triazolic moieties, namely 4H-4-(2-hydroxy-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole and 4H-4-(4-nitro-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole using thin layer chromatography, melting interval, elemental analysis, spectroscopy and thermal stability studies.

Show MeSH