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The potential of minor ginsenosides isolated from the leaves of Panax ginseng as inhibitors of melanogenesis.

Lee DY, Cha BJ, Lee YS, Kim GS, Noh HJ, Kim SY, Kang HC, Kim JH, Baek NI - Int J Mol Sci (2015)

Bottom Line: The melanogenic inhibitory activity of compounds 1, 2 and 3 was 23.9%, 27.8% and 35.2%, respectively, at a concentration of 80 µM.Likewise, the three compounds showed inhibitory activity on body pigmentation on a zebrafish model, which is commonly used as a model for biomedical or cosmetic research.These results from in vitro and in vivo systems suggest that the three aforementioned compounds isolated from Panax ginseng may have potential as new skin whitening compounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-837, Korea. dylee0809@gmail.com.

ABSTRACT
Three minor ginsenosides, namely, ginsenoside Rh6 (1), vina-ginsenoside R4 (2) and vina-ginsenoside R13 (3), were isolated from the leaves of hydroponic Panax ginseng. The chemical structures were determined based on spectroscopic methods, including fast atom bombardment mass spectroscopy (FAB-MS), 1D-nuclear magnetic resonance (NMR), 2D-NMR, and, infrared (IR) spectroscopy. The melanogenic inhibitory activity of compounds 1, 2 and 3 was 23.9%, 27.8% and 35.2%, respectively, at a concentration of 80 µM. Likewise, the three compounds showed inhibitory activity on body pigmentation on a zebrafish model, which is commonly used as a model for biomedical or cosmetic research. These results from in vitro and in vivo systems suggest that the three aforementioned compounds isolated from Panax ginseng may have potential as new skin whitening compounds.

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Chemical structures of compounds 1–3 isolated from the leaves of P. ginseng.
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ijms-16-01677-f001: Chemical structures of compounds 1–3 isolated from the leaves of P. ginseng.

Mentions: Leaves of hydroponic P. ginseng were extracted with acqueous MeOH and partitioned into ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O fractions, respectively. Repeated SiO2 and ODS column chromatographies of the EtOAc and n-BuOH fractions afforded three ginsenosides (1–3) (Figure 1).


The potential of minor ginsenosides isolated from the leaves of Panax ginseng as inhibitors of melanogenesis.

Lee DY, Cha BJ, Lee YS, Kim GS, Noh HJ, Kim SY, Kang HC, Kim JH, Baek NI - Int J Mol Sci (2015)

Chemical structures of compounds 1–3 isolated from the leaves of P. ginseng.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4307327&req=5

ijms-16-01677-f001: Chemical structures of compounds 1–3 isolated from the leaves of P. ginseng.
Mentions: Leaves of hydroponic P. ginseng were extracted with acqueous MeOH and partitioned into ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O fractions, respectively. Repeated SiO2 and ODS column chromatographies of the EtOAc and n-BuOH fractions afforded three ginsenosides (1–3) (Figure 1).

Bottom Line: The melanogenic inhibitory activity of compounds 1, 2 and 3 was 23.9%, 27.8% and 35.2%, respectively, at a concentration of 80 µM.Likewise, the three compounds showed inhibitory activity on body pigmentation on a zebrafish model, which is commonly used as a model for biomedical or cosmetic research.These results from in vitro and in vivo systems suggest that the three aforementioned compounds isolated from Panax ginseng may have potential as new skin whitening compounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-837, Korea. dylee0809@gmail.com.

ABSTRACT
Three minor ginsenosides, namely, ginsenoside Rh6 (1), vina-ginsenoside R4 (2) and vina-ginsenoside R13 (3), were isolated from the leaves of hydroponic Panax ginseng. The chemical structures were determined based on spectroscopic methods, including fast atom bombardment mass spectroscopy (FAB-MS), 1D-nuclear magnetic resonance (NMR), 2D-NMR, and, infrared (IR) spectroscopy. The melanogenic inhibitory activity of compounds 1, 2 and 3 was 23.9%, 27.8% and 35.2%, respectively, at a concentration of 80 µM. Likewise, the three compounds showed inhibitory activity on body pigmentation on a zebrafish model, which is commonly used as a model for biomedical or cosmetic research. These results from in vitro and in vivo systems suggest that the three aforementioned compounds isolated from Panax ginseng may have potential as new skin whitening compounds.

Show MeSH
Related in: MedlinePlus