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Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors.

Nakagawa Y, Akao Y, Taniguchi K, Kamatani A, Tahara T, Kamano T, Nakano N, Komura N, Ikuno H, Ohmori T, Jodai Y, Miyata M, Nagasaka M, Shibata T, Ohmiya N, Hirata I - Int J Mol Sci (2015)

Bottom Line: The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas.In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process.These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. yo-hi@fujita-hu.ac.jp.

ABSTRACT
Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We examined the expression of onco-related miRNAs in 131 sporadic exophytic adenomas or early cancers and in 52 sporadic flat elevated adenomas or early cancers to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. The expression levels of miR-143, -145, and -34a were significantly reduced in most of the exophytic tumors compared with those in the flat elevated ones. In type 2 cancers, the miRNA expression profile was very similar to that of the exophytic tumors. The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas. In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process. These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.

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Endoscopic appearance of exophytic and flat elevated tumors (Japanese classification of colorectal carcinoma (8th ed.)) [30]. (a) Exophytic type: Ip = pedunculated type; Isp = semipedunculated type; Is = sessile type; and (b) Flat elevated type: IIa = superficial elevated type; LST-G = laterally spreading tumor, granular type; LST-NG = laterally spreading tumor, non-granular type.
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ijms-16-01526-f001: Endoscopic appearance of exophytic and flat elevated tumors (Japanese classification of colorectal carcinoma (8th ed.)) [30]. (a) Exophytic type: Ip = pedunculated type; Isp = semipedunculated type; Is = sessile type; and (b) Flat elevated type: IIa = superficial elevated type; LST-G = laterally spreading tumor, granular type; LST-NG = laterally spreading tumor, non-granular type.

Mentions: Recent studies indicated that exophytic tumors (Figure 1a) and flat elevated tumors (Figure 1b) differ in the expression profile of their genome [21,22,23,24,25]. A Ki-Ras gene point mutation is frequently observed in exophytic tumors but is very rare in the flat elevated ones [21,22]. Moreover, large flat elevated tumors (over 10 mm), called laterally spreading tumor (LSTs) [25,26] are classified as granular type (LST-G) and non-granular type (LST-NG), according to their endoscopic appearance [25,26,27]. The LST-NG is more malignant than the LST-G [27]. Although the frequency of the Ki-Ras point mutation in LST-NG is lower than that in LST-G [28,29], there has been no report as of yet indicating any difference in the miRNA expression profile between exophytic tumors and flat elevated ones.


Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors.

Nakagawa Y, Akao Y, Taniguchi K, Kamatani A, Tahara T, Kamano T, Nakano N, Komura N, Ikuno H, Ohmori T, Jodai Y, Miyata M, Nagasaka M, Shibata T, Ohmiya N, Hirata I - Int J Mol Sci (2015)

Endoscopic appearance of exophytic and flat elevated tumors (Japanese classification of colorectal carcinoma (8th ed.)) [30]. (a) Exophytic type: Ip = pedunculated type; Isp = semipedunculated type; Is = sessile type; and (b) Flat elevated type: IIa = superficial elevated type; LST-G = laterally spreading tumor, granular type; LST-NG = laterally spreading tumor, non-granular type.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4307318&req=5

ijms-16-01526-f001: Endoscopic appearance of exophytic and flat elevated tumors (Japanese classification of colorectal carcinoma (8th ed.)) [30]. (a) Exophytic type: Ip = pedunculated type; Isp = semipedunculated type; Is = sessile type; and (b) Flat elevated type: IIa = superficial elevated type; LST-G = laterally spreading tumor, granular type; LST-NG = laterally spreading tumor, non-granular type.
Mentions: Recent studies indicated that exophytic tumors (Figure 1a) and flat elevated tumors (Figure 1b) differ in the expression profile of their genome [21,22,23,24,25]. A Ki-Ras gene point mutation is frequently observed in exophytic tumors but is very rare in the flat elevated ones [21,22]. Moreover, large flat elevated tumors (over 10 mm), called laterally spreading tumor (LSTs) [25,26] are classified as granular type (LST-G) and non-granular type (LST-NG), according to their endoscopic appearance [25,26,27]. The LST-NG is more malignant than the LST-G [27]. Although the frequency of the Ki-Ras point mutation in LST-NG is lower than that in LST-G [28,29], there has been no report as of yet indicating any difference in the miRNA expression profile between exophytic tumors and flat elevated ones.

Bottom Line: The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas.In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process.These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. yo-hi@fujita-hu.ac.jp.

ABSTRACT
Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We examined the expression of onco-related miRNAs in 131 sporadic exophytic adenomas or early cancers and in 52 sporadic flat elevated adenomas or early cancers to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. The expression levels of miR-143, -145, and -34a were significantly reduced in most of the exophytic tumors compared with those in the flat elevated ones. In type 2 cancers, the miRNA expression profile was very similar to that of the exophytic tumors. The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas. In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process. These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.

Show MeSH
Related in: MedlinePlus