Limits...
MicroRNA expression profiling of lactating mammary gland in divergent phenotype swine breeds.

Peng J, Zhao JS, Shen YF, Mao HG, Xu NY - Int J Mol Sci (2015)

Bottom Line: However, little is known about porcine mammary gland miRNAs.In this study, we report the identification and characterization of miRNAs in the lactating mammary gland in two distinct pig breeds, Jinhua and Yorkshire.Many miRNAs were detected as significantly differentially expressed between the two libraries.

View Article: PubMed Central - PubMed

Affiliation: College of Animal Sciences, Zhejiang University, Hangzhou 310058, China. pennypeng1987@163.com.

ABSTRACT
MicroRNA (miRNA) plays a key role in development and specific biological processes, such as cell proliferation, differentiation, and apoptosis. Extensive studies of mammary miRNAs have been performed in different species and tissues. However, little is known about porcine mammary gland miRNAs. In this study, we report the identification and characterization of miRNAs in the lactating mammary gland in two distinct pig breeds, Jinhua and Yorkshire. Many miRNAs were detected as significantly differentially expressed between the two libraries. Among the differentially expressed miRNAs, many are known to be related to mammary gland development and lactation by interacting with putative target genes in previous studies. These findings suggest that miRNA expression patterns may contribute significantly to target mRNA regulation and influence mammary gland development and peak lactation performance. The data we obtained provide useful information about the roles of miRNAs in the biological processes of lactation and the mechanisms of target gene expression and regulation.

Show MeSH

Related in: MedlinePlus

Conservation comparison of the identified miRNAs.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4307312&req=5

ijms-16-01448-f006: Conservation comparison of the identified miRNAs.

Mentions: Conserved miRNA families are found in many animal species and have important functions in animal development and physiological processes. In our study, the sequences were also mapped to other mammalian genomes, and many miRNA families are conserved in a variety of animal species. For example, miR-542 was found in most species, including Homo sapiens, Bos Taurus, Mus musculus, Pan troglodytes, Canis familiaris, Equus caballus, Rattus norvegicus, Gorilla gorilla, and Macaca mulatta. The conservation of the identified miRNAs with other species is shown in Figure 6. In general, the porcine miRNA population is most conserved in Homo sapiens, Bos taurus and Mus musculus.


MicroRNA expression profiling of lactating mammary gland in divergent phenotype swine breeds.

Peng J, Zhao JS, Shen YF, Mao HG, Xu NY - Int J Mol Sci (2015)

Conservation comparison of the identified miRNAs.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4307312&req=5

ijms-16-01448-f006: Conservation comparison of the identified miRNAs.
Mentions: Conserved miRNA families are found in many animal species and have important functions in animal development and physiological processes. In our study, the sequences were also mapped to other mammalian genomes, and many miRNA families are conserved in a variety of animal species. For example, miR-542 was found in most species, including Homo sapiens, Bos Taurus, Mus musculus, Pan troglodytes, Canis familiaris, Equus caballus, Rattus norvegicus, Gorilla gorilla, and Macaca mulatta. The conservation of the identified miRNAs with other species is shown in Figure 6. In general, the porcine miRNA population is most conserved in Homo sapiens, Bos taurus and Mus musculus.

Bottom Line: However, little is known about porcine mammary gland miRNAs.In this study, we report the identification and characterization of miRNAs in the lactating mammary gland in two distinct pig breeds, Jinhua and Yorkshire.Many miRNAs were detected as significantly differentially expressed between the two libraries.

View Article: PubMed Central - PubMed

Affiliation: College of Animal Sciences, Zhejiang University, Hangzhou 310058, China. pennypeng1987@163.com.

ABSTRACT
MicroRNA (miRNA) plays a key role in development and specific biological processes, such as cell proliferation, differentiation, and apoptosis. Extensive studies of mammary miRNAs have been performed in different species and tissues. However, little is known about porcine mammary gland miRNAs. In this study, we report the identification and characterization of miRNAs in the lactating mammary gland in two distinct pig breeds, Jinhua and Yorkshire. Many miRNAs were detected as significantly differentially expressed between the two libraries. Among the differentially expressed miRNAs, many are known to be related to mammary gland development and lactation by interacting with putative target genes in previous studies. These findings suggest that miRNA expression patterns may contribute significantly to target mRNA regulation and influence mammary gland development and peak lactation performance. The data we obtained provide useful information about the roles of miRNAs in the biological processes of lactation and the mechanisms of target gene expression and regulation.

Show MeSH
Related in: MedlinePlus