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Association between ADIPOQ +45T>G polymorphism and type 2 diabetes: a systematic review and meta-analysis.

Fan Y, Wang K, Xu S, Chen G, Di H, Cao M, Liu C - Int J Mol Sci (2014)

Bottom Line: The +45 T>G polymorphism was associated with an overall significantly increased risk of T2DM (G vs.Subgroup analysis revealed a significant association between the +45 T>G polymorphism and T2D in an Asian population.Thus, this meta-analysis indicates that the G allele of the ADIPOQ +45 T>G polymorphisms associated with a significantly increased risk of T2DM in the Asian population.

View Article: PubMed Central - PubMed

Affiliation: Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China. fanyaofu2010@163.com.

ABSTRACT
Recently, a number of studies have reported the association between the single nucleotide polymorphisms (SNPs) +45 T>G polymorphism in the adiponectin (ADIPOQ) gene and type 2 diabetes mellitus (T2DM) risk, though the results are inconsistent. In order to obtain a more precise estimation of the relationship, a meta-analysis was performed. In this current study, the Medline, Embase, Pubmed, ISI Web of Knowledge, Ovid, Science Citation Index Expanded Database, Wanfang Database, and China National Knowledge Infrastructure were searched for eligible studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of association. Forty-five publications were included in the final meta-analysis with 9986 T2DM patients and 16,222 controls for ADIPOQ +45 T>G polymorphism according to our inclusion and exclusion criteria. The +45 T>G polymorphism was associated with an overall significantly increased risk of T2DM (G vs. T: OR = 1.18, 95% CI = 1.06-1.32; The dominant model: OR = 1.18, 95% CI = 1.03-1.33; The recessive model: OR = 1.47, 95% CI = 1.20-1.78; The homozygous model: OR = 1.62, 95% CI = 1.25-2.09; Except the heterozygous model: OR = 1.11, 95% CI = 0.98-1.24). Subgroup analysis revealed a significant association between the +45 T>G polymorphism and T2D in an Asian population. Thus, this meta-analysis indicates that the G allele of the ADIPOQ +45 T>G polymorphisms associated with a significantly increased risk of T2DM in the Asian population.

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Related in: MedlinePlus

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ijms-16-00704-f001: Study flow diagram.

Mentions: A total of 260 studies were identified by the literature search. Of these, the first screening excluded 187 citations based on abstracts or titles, leaving 73 articles for full text reports. Applying the study inclusion criteria, 44 studies were included in this meta-analysis (Figure 1). A total of 9786 cases and 16,022 controls were included in the +45T>G analysis. Table 1 lists the main characteristics of the 44 studies eligible for the meta-analysis. These populations belong to Caucasian and Asian subgroups respectively. The Caucasian subgroup includes 14 individual studies and the Asian subgroup comprises 30 individual studies.


Association between ADIPOQ +45T>G polymorphism and type 2 diabetes: a systematic review and meta-analysis.

Fan Y, Wang K, Xu S, Chen G, Di H, Cao M, Liu C - Int J Mol Sci (2014)

Study flow diagram.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4307270&req=5

ijms-16-00704-f001: Study flow diagram.
Mentions: A total of 260 studies were identified by the literature search. Of these, the first screening excluded 187 citations based on abstracts or titles, leaving 73 articles for full text reports. Applying the study inclusion criteria, 44 studies were included in this meta-analysis (Figure 1). A total of 9786 cases and 16,022 controls were included in the +45T>G analysis. Table 1 lists the main characteristics of the 44 studies eligible for the meta-analysis. These populations belong to Caucasian and Asian subgroups respectively. The Caucasian subgroup includes 14 individual studies and the Asian subgroup comprises 30 individual studies.

Bottom Line: The +45 T>G polymorphism was associated with an overall significantly increased risk of T2DM (G vs.Subgroup analysis revealed a significant association between the +45 T>G polymorphism and T2D in an Asian population.Thus, this meta-analysis indicates that the G allele of the ADIPOQ +45 T>G polymorphisms associated with a significantly increased risk of T2DM in the Asian population.

View Article: PubMed Central - PubMed

Affiliation: Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China. fanyaofu2010@163.com.

ABSTRACT
Recently, a number of studies have reported the association between the single nucleotide polymorphisms (SNPs) +45 T>G polymorphism in the adiponectin (ADIPOQ) gene and type 2 diabetes mellitus (T2DM) risk, though the results are inconsistent. In order to obtain a more precise estimation of the relationship, a meta-analysis was performed. In this current study, the Medline, Embase, Pubmed, ISI Web of Knowledge, Ovid, Science Citation Index Expanded Database, Wanfang Database, and China National Knowledge Infrastructure were searched for eligible studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of association. Forty-five publications were included in the final meta-analysis with 9986 T2DM patients and 16,222 controls for ADIPOQ +45 T>G polymorphism according to our inclusion and exclusion criteria. The +45 T>G polymorphism was associated with an overall significantly increased risk of T2DM (G vs. T: OR = 1.18, 95% CI = 1.06-1.32; The dominant model: OR = 1.18, 95% CI = 1.03-1.33; The recessive model: OR = 1.47, 95% CI = 1.20-1.78; The homozygous model: OR = 1.62, 95% CI = 1.25-2.09; Except the heterozygous model: OR = 1.11, 95% CI = 0.98-1.24). Subgroup analysis revealed a significant association between the +45 T>G polymorphism and T2D in an Asian population. Thus, this meta-analysis indicates that the G allele of the ADIPOQ +45 T>G polymorphisms associated with a significantly increased risk of T2DM in the Asian population.

Show MeSH
Related in: MedlinePlus