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tRNAs as antibiotic targets.

Chopra S, Reader J - Int J Mol Sci (2014)

Bottom Line: This review focuses on the role of tRNAs in bacterial antibiosis.We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome.Finally, the role of deacylated tRNAs in the bacterial "stringent response" mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed.

View Article: PubMed Central - PubMed

Affiliation: . schopra@email.unc.edu.

ABSTRACT
Transfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome. Finally, the role of deacylated tRNAs in the bacterial "stringent response" mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed.

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Reaction catalyzed by non-discriminating AspRS/GluRS and amidotransferases (modified from Tambula-Hansen et al., [161]).
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ijms-16-00321-f004: Reaction catalyzed by non-discriminating AspRS/GluRS and amidotransferases (modified from Tambula-Hansen et al., [161]).


tRNAs as antibiotic targets.

Chopra S, Reader J - Int J Mol Sci (2014)

Reaction catalyzed by non-discriminating AspRS/GluRS and amidotransferases (modified from Tambula-Hansen et al., [161]).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4307249&req=5

ijms-16-00321-f004: Reaction catalyzed by non-discriminating AspRS/GluRS and amidotransferases (modified from Tambula-Hansen et al., [161]).
Bottom Line: This review focuses on the role of tRNAs in bacterial antibiosis.We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome.Finally, the role of deacylated tRNAs in the bacterial "stringent response" mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed.

View Article: PubMed Central - PubMed

Affiliation: . schopra@email.unc.edu.

ABSTRACT
Transfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome. Finally, the role of deacylated tRNAs in the bacterial "stringent response" mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed.

Show MeSH