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A nationwide population-based cohort study to identify the correlation between heart failure and the subsequent risk of herpes zoster.

Wu PH, Lin YT, Lin CY, Huang MY, Chang WC, Chang WP - BMC Infect. Dis. (2015)

Bottom Line: Our study cohort consisted of patients who received a diagnosis of HF in 2001 ~ 2009 (N = 4785).We found that male patients with HF had an increased risk of developing herpes zoster (AHR: 2.30 95% CI: 1.51 ~ 3.50; p < 0.001).These health associations should be taken into consideration, and further studies should focused on the cost-effectiveness of the herpes zoster vaccine should be designed for HF patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. 970392@mail.kmuh.org.tw.

ABSTRACT

Background: The association between heart failure (HF) and herpes zoster has rarely been studied. We investigated the hypothesis that HF may increase the risk of herpes zoster in Taiwan using a nationwide Taiwanese population-based claims database.

Method: Our study cohort consisted of patients who received a diagnosis of HF in 2001 ~ 2009 (N = 4785). For a comparison cohort, three age- and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 14,355). All subjects were tracked for 1 year from the date of cohort entry to identify whether or not they had developed herpes zoster. Cox proportional-hazard regressions were performed to evaluate 1-year herpes zoster-free survival rates.

Results: The main finding of this study was that patients with HF seemed to be at an increased risk of developing herpes zoster. Of the total patients, 211 patients developed herpes zoster during the 1-year follow-up period, among whom 83 were HF patients and 128 were in the comparison cohort. The adjusted hazard ratio (AHR) of herpes zoster in patients with HF was higher (AHR: 2.07; 95% confidence interval (CI): 1.54 ~ 2.78; p < 0.001) than that of the controls during the 1-year follow-up. Our study also investigated whether HF is a gender-dependent risk factor for herpes zoster. We found that male patients with HF had an increased risk of developing herpes zoster (AHR: 2.30 95% CI: 1.51 ~ 3.50; p < 0.001).

Conclusions: The findings of our population-based study suggest that patients with HF may have an increased risk of herpes zoster. These health associations should be taken into consideration, and further studies should focused on the cost-effectiveness of the herpes zoster vaccine should be designed for HF patients.

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Related in: MedlinePlus

Herpes Zoster-free survival rates for patient with heart failure patients and comparison groups from 2001 to 2009.
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Fig2: Herpes Zoster-free survival rates for patient with heart failure patients and comparison groups from 2001 to 2009.

Mentions: There were 211 patients diagnosed with herpes zoster during the 1-year follow-up, including 83 HF patients (1.7%) and 128 patients in the comparison cohort (0.9%). The Kaplan-Meier survival curves are shown in Figure 2. The curves demonstrate significantly lower herpes zoster-free survival rates in the HF cohort than in the comparison cohort (log-rank test, p < .001). The overall incidence rate was higher in the HF cohort (17.61 per 1000 patient-years) than in the comparison cohort (8.95 per 1000 patient-years).Figure 2


A nationwide population-based cohort study to identify the correlation between heart failure and the subsequent risk of herpes zoster.

Wu PH, Lin YT, Lin CY, Huang MY, Chang WC, Chang WP - BMC Infect. Dis. (2015)

Herpes Zoster-free survival rates for patient with heart failure patients and comparison groups from 2001 to 2009.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4307190&req=5

Fig2: Herpes Zoster-free survival rates for patient with heart failure patients and comparison groups from 2001 to 2009.
Mentions: There were 211 patients diagnosed with herpes zoster during the 1-year follow-up, including 83 HF patients (1.7%) and 128 patients in the comparison cohort (0.9%). The Kaplan-Meier survival curves are shown in Figure 2. The curves demonstrate significantly lower herpes zoster-free survival rates in the HF cohort than in the comparison cohort (log-rank test, p < .001). The overall incidence rate was higher in the HF cohort (17.61 per 1000 patient-years) than in the comparison cohort (8.95 per 1000 patient-years).Figure 2

Bottom Line: Our study cohort consisted of patients who received a diagnosis of HF in 2001 ~ 2009 (N = 4785).We found that male patients with HF had an increased risk of developing herpes zoster (AHR: 2.30 95% CI: 1.51 ~ 3.50; p < 0.001).These health associations should be taken into consideration, and further studies should focused on the cost-effectiveness of the herpes zoster vaccine should be designed for HF patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. 970392@mail.kmuh.org.tw.

ABSTRACT

Background: The association between heart failure (HF) and herpes zoster has rarely been studied. We investigated the hypothesis that HF may increase the risk of herpes zoster in Taiwan using a nationwide Taiwanese population-based claims database.

Method: Our study cohort consisted of patients who received a diagnosis of HF in 2001 ~ 2009 (N = 4785). For a comparison cohort, three age- and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 14,355). All subjects were tracked for 1 year from the date of cohort entry to identify whether or not they had developed herpes zoster. Cox proportional-hazard regressions were performed to evaluate 1-year herpes zoster-free survival rates.

Results: The main finding of this study was that patients with HF seemed to be at an increased risk of developing herpes zoster. Of the total patients, 211 patients developed herpes zoster during the 1-year follow-up period, among whom 83 were HF patients and 128 were in the comparison cohort. The adjusted hazard ratio (AHR) of herpes zoster in patients with HF was higher (AHR: 2.07; 95% confidence interval (CI): 1.54 ~ 2.78; p < 0.001) than that of the controls during the 1-year follow-up. Our study also investigated whether HF is a gender-dependent risk factor for herpes zoster. We found that male patients with HF had an increased risk of developing herpes zoster (AHR: 2.30 95% CI: 1.51 ~ 3.50; p < 0.001).

Conclusions: The findings of our population-based study suggest that patients with HF may have an increased risk of herpes zoster. These health associations should be taken into consideration, and further studies should focused on the cost-effectiveness of the herpes zoster vaccine should be designed for HF patients.

Show MeSH
Related in: MedlinePlus