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Autonomic dysfunction in women with polycystic ovary syndrome.

Hashim ZH, Hamdan FB, Al-Salihi AR - Iran J Reprod Med (2015)

Bottom Line: Central obesity and hyperinsulinaemia of polycystic ovary syndrome (PCOS) are associated with chronic sympathetic over activity.The two groups were subdivided according to the body mass index (BMI) into two obese and non-obese groups.Receiver operating characteristics curve demonstrate the pulse rate in standing position as the autonomic function test that is superior to others in predicting sympathetic over activity in those patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq.

ABSTRACT

Background: Central obesity and hyperinsulinaemia of polycystic ovary syndrome (PCOS) are associated with chronic sympathetic over activity.

Objective: To evaluate the autonomic functions and to indicate the superiority, if any, for those functions in the diagnosis of sympathetic over activity in PCOS women.

Materials and methods: Sixty-four PCOS patients and 40 women served as the control group were studied. The two groups were subdivided according to the body mass index (BMI) into two obese and non-obese groups. Waist:hip ratio (WHR), plasma epinephrine level was estimated, sympathetic skin response (SSR); postural orthostatic tachycardia syndrome, heart rate variability (HRV), and valsalva ratio were measured in both groups.

Results: Compared to the control group, obese PCOS patients demonstrated higher BMI and WHR, reduced palmar SSR latency and higher amplitude, altered HRV, higher plasma epinephrine level, and rapid pulse rate. Moreover, non-obese patients show reduced palmar SSR latency and higher amplitude, higher plasma epinephrine level, and higher pulse rate. BMI and WHR of the patients were positively correlated with plasma epinephrine level; while the HRV was negatively correlated WHR.

Conclusion: Women with PCOS exhibits altered autonomic function and sympathoexcitation is more pronounced in obese than non-obese patients; therefor the SSR could be useful auxiliary electrophysiological test to predict autonomic dysfunction in those patients. Receiver operating characteristics curve demonstrate the pulse rate in standing position as the autonomic function test that is superior to others in predicting sympathetic over activity in those patients.

No MeSH data available.


Related in: MedlinePlus

Correlation of waist/hip ratio with plasma epinephrine level in lying position in PCOS patients.
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Figure 2: Correlation of waist/hip ratio with plasma epinephrine level in lying position in PCOS patients.

Mentions: The ROC curve showed that pulse rate in standing position has the highest area under the curve followed in sequence by palmar SSR latency, pulse rate in supine position, palmar SSR amplitude, pNN50% and systolic BP in supine position (Table III). Considering the specificity and sensitivity of the autonomic function that showed significant difference between PCOS patients and control group; ROC curve demonstrate that the pulse rate in standing position show the highest specificity (94.4%) and sensitivity (81%) as compared to the other tests (Table IV). The BMI and WHR of PCOS patients were positively correlated with plasma epinephrine level in lying position (Figures 1, 2). Moreover, a negative correlation (r=-0.371; p=0.047) was observed between SDNN parameter of the HRV and WHR in PCOS patients (Figure 3).


Autonomic dysfunction in women with polycystic ovary syndrome.

Hashim ZH, Hamdan FB, Al-Salihi AR - Iran J Reprod Med (2015)

Correlation of waist/hip ratio with plasma epinephrine level in lying position in PCOS patients.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306982&req=5

Figure 2: Correlation of waist/hip ratio with plasma epinephrine level in lying position in PCOS patients.
Mentions: The ROC curve showed that pulse rate in standing position has the highest area under the curve followed in sequence by palmar SSR latency, pulse rate in supine position, palmar SSR amplitude, pNN50% and systolic BP in supine position (Table III). Considering the specificity and sensitivity of the autonomic function that showed significant difference between PCOS patients and control group; ROC curve demonstrate that the pulse rate in standing position show the highest specificity (94.4%) and sensitivity (81%) as compared to the other tests (Table IV). The BMI and WHR of PCOS patients were positively correlated with plasma epinephrine level in lying position (Figures 1, 2). Moreover, a negative correlation (r=-0.371; p=0.047) was observed between SDNN parameter of the HRV and WHR in PCOS patients (Figure 3).

Bottom Line: Central obesity and hyperinsulinaemia of polycystic ovary syndrome (PCOS) are associated with chronic sympathetic over activity.The two groups were subdivided according to the body mass index (BMI) into two obese and non-obese groups.Receiver operating characteristics curve demonstrate the pulse rate in standing position as the autonomic function test that is superior to others in predicting sympathetic over activity in those patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq.

ABSTRACT

Background: Central obesity and hyperinsulinaemia of polycystic ovary syndrome (PCOS) are associated with chronic sympathetic over activity.

Objective: To evaluate the autonomic functions and to indicate the superiority, if any, for those functions in the diagnosis of sympathetic over activity in PCOS women.

Materials and methods: Sixty-four PCOS patients and 40 women served as the control group were studied. The two groups were subdivided according to the body mass index (BMI) into two obese and non-obese groups. Waist:hip ratio (WHR), plasma epinephrine level was estimated, sympathetic skin response (SSR); postural orthostatic tachycardia syndrome, heart rate variability (HRV), and valsalva ratio were measured in both groups.

Results: Compared to the control group, obese PCOS patients demonstrated higher BMI and WHR, reduced palmar SSR latency and higher amplitude, altered HRV, higher plasma epinephrine level, and rapid pulse rate. Moreover, non-obese patients show reduced palmar SSR latency and higher amplitude, higher plasma epinephrine level, and higher pulse rate. BMI and WHR of the patients were positively correlated with plasma epinephrine level; while the HRV was negatively correlated WHR.

Conclusion: Women with PCOS exhibits altered autonomic function and sympathoexcitation is more pronounced in obese than non-obese patients; therefor the SSR could be useful auxiliary electrophysiological test to predict autonomic dysfunction in those patients. Receiver operating characteristics curve demonstrate the pulse rate in standing position as the autonomic function test that is superior to others in predicting sympathetic over activity in those patients.

No MeSH data available.


Related in: MedlinePlus