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Marine structure derived calcium phosphate-polymer biocomposites for local antibiotic delivery.

Macha IJ, Cazalbou S, Ben-Nissan B, Harvey KL, Milthorpe B - Mar Drugs (2015)

Bottom Line: The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier.The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria.The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia. innocent.macha@uts.edu.au.

ABSTRACT
Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca2+ for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by S. aureus in surgery.

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Fractional cumulative release of gentamicin from polylactic acid (PLA) thin film composite in phosphate buffered saline (PBS) solution (pH 7.4, 37 °C and 100 rpm), for eight weeks. Error bars are mean standard deviation (SD) of triplicate experimental data.
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marinedrugs-13-00666-f003: Fractional cumulative release of gentamicin from polylactic acid (PLA) thin film composite in phosphate buffered saline (PBS) solution (pH 7.4, 37 °C and 100 rpm), for eight weeks. Error bars are mean standard deviation (SD) of triplicate experimental data.

Mentions: The central objective of a delivery system is to release therapeutics at the desired anatomical site and to maintain the drug concentration within a therapeutic band for a desired duration. Prolonged release of gentamicin from PLA thin film composites was studied and presented in Figure 3. Generally, the release of drug from biodegradable systems is rather complex phenomenon which can be governed by diffusion, dissolution, erosion and most often by a combination of these mechanisms. That is the reason why an adequate empirical or semi-empirical model that incorporates most of the release governing factors is required for the assessment of the release kinetics.


Marine structure derived calcium phosphate-polymer biocomposites for local antibiotic delivery.

Macha IJ, Cazalbou S, Ben-Nissan B, Harvey KL, Milthorpe B - Mar Drugs (2015)

Fractional cumulative release of gentamicin from polylactic acid (PLA) thin film composite in phosphate buffered saline (PBS) solution (pH 7.4, 37 °C and 100 rpm), for eight weeks. Error bars are mean standard deviation (SD) of triplicate experimental data.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306957&req=5

marinedrugs-13-00666-f003: Fractional cumulative release of gentamicin from polylactic acid (PLA) thin film composite in phosphate buffered saline (PBS) solution (pH 7.4, 37 °C and 100 rpm), for eight weeks. Error bars are mean standard deviation (SD) of triplicate experimental data.
Mentions: The central objective of a delivery system is to release therapeutics at the desired anatomical site and to maintain the drug concentration within a therapeutic band for a desired duration. Prolonged release of gentamicin from PLA thin film composites was studied and presented in Figure 3. Generally, the release of drug from biodegradable systems is rather complex phenomenon which can be governed by diffusion, dissolution, erosion and most often by a combination of these mechanisms. That is the reason why an adequate empirical or semi-empirical model that incorporates most of the release governing factors is required for the assessment of the release kinetics.

Bottom Line: The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier.The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria.The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia. innocent.macha@uts.edu.au.

ABSTRACT
Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca2+ for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by S. aureus in surgery.

Show MeSH
Related in: MedlinePlus