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Marine structure derived calcium phosphate-polymer biocomposites for local antibiotic delivery.

Macha IJ, Cazalbou S, Ben-Nissan B, Harvey KL, Milthorpe B - Mar Drugs (2015)

Bottom Line: The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier.The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria.The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia. innocent.macha@uts.edu.au.

ABSTRACT
Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca2+ for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by S. aureus in surgery.

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(a) Hydrothermal converted coralline HAp; (b) Gentamicin coated coralline HAp.
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marinedrugs-13-00666-f001: (a) Hydrothermal converted coralline HAp; (b) Gentamicin coated coralline HAp.

Mentions: Scanning electron microscopy (SEM) was used to analyze drug loading into HAp particles. Figure 1 shows images of HAp before and after drug loading. It was evident that converted coral particles are coated with drug into micro, meso and nanopores as drug solution could easily penetrate into these pores. On the other hand the surface of HAp before loading reveals thin platelets of HAp crystals while after loading the surface looks relative smooth due to drug coating.


Marine structure derived calcium phosphate-polymer biocomposites for local antibiotic delivery.

Macha IJ, Cazalbou S, Ben-Nissan B, Harvey KL, Milthorpe B - Mar Drugs (2015)

(a) Hydrothermal converted coralline HAp; (b) Gentamicin coated coralline HAp.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306957&req=5

marinedrugs-13-00666-f001: (a) Hydrothermal converted coralline HAp; (b) Gentamicin coated coralline HAp.
Mentions: Scanning electron microscopy (SEM) was used to analyze drug loading into HAp particles. Figure 1 shows images of HAp before and after drug loading. It was evident that converted coral particles are coated with drug into micro, meso and nanopores as drug solution could easily penetrate into these pores. On the other hand the surface of HAp before loading reveals thin platelets of HAp crystals while after loading the surface looks relative smooth due to drug coating.

Bottom Line: The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier.The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria.The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia. innocent.macha@uts.edu.au.

ABSTRACT
Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca2+ for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by S. aureus in surgery.

Show MeSH
Related in: MedlinePlus