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Marine peptides and their anti-infective activities.

Kang HK, Seo CH, Park Y - Mar Drugs (2015)

Bottom Line: Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities.In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites.Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea. hkkang129@gmail.com.

ABSTRACT
Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present.

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Structure of albopunctatone (63). Albopunctatone was isolated ascidian Didemnum albopunctatum [76].
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marinedrugs-13-00618-f014: Structure of albopunctatone (63). Albopunctatone was isolated ascidian Didemnum albopunctatum [76].

Mentions: Carroll et al. isolated a new anthrone-anthraquinone, albopunctatone (64) in the MeOH extract of the Great Barrier Reef ascidian Didemnum albopunctatum, which had moderately antimalarial activity (IC50 = 5.3 and 4.4 ± 0.5 μM) against chloroquine-resistant (Dd2) and -sensitive strains (3d7) of Plasmodium falciparum [76]. Albopunctatone (64) was also inactive up to 40 μM when tested against a variety of cancerous and normal human cell lines and the kinetoplastid Trypanosoma brucei brucei, indicating selectivity for the malaria parasite, P. falciparum [76] (Figure 14).


Marine peptides and their anti-infective activities.

Kang HK, Seo CH, Park Y - Mar Drugs (2015)

Structure of albopunctatone (63). Albopunctatone was isolated ascidian Didemnum albopunctatum [76].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306955&req=5

marinedrugs-13-00618-f014: Structure of albopunctatone (63). Albopunctatone was isolated ascidian Didemnum albopunctatum [76].
Mentions: Carroll et al. isolated a new anthrone-anthraquinone, albopunctatone (64) in the MeOH extract of the Great Barrier Reef ascidian Didemnum albopunctatum, which had moderately antimalarial activity (IC50 = 5.3 and 4.4 ± 0.5 μM) against chloroquine-resistant (Dd2) and -sensitive strains (3d7) of Plasmodium falciparum [76]. Albopunctatone (64) was also inactive up to 40 μM when tested against a variety of cancerous and normal human cell lines and the kinetoplastid Trypanosoma brucei brucei, indicating selectivity for the malaria parasite, P. falciparum [76] (Figure 14).

Bottom Line: Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities.In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites.Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea. hkkang129@gmail.com.

ABSTRACT
Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present.

Show MeSH
Related in: MedlinePlus