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Marine peptides and their anti-infective activities.

Kang HK, Seo CH, Park Y - Mar Drugs (2015)

Bottom Line: Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities.In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites.Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea. hkkang129@gmail.com.

ABSTRACT
Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present.

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Structure of cytosporomes B (33) and E (34). Cytosporomes were isolated a strain of the endophytic fungus Leucostoma persoonii [54].
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marinedrugs-13-00618-f010: Structure of cytosporomes B (33) and E (34). Cytosporomes were isolated a strain of the endophytic fungus Leucostoma persoonii [54].

Mentions: Cytosporomes B (33) and E (34) isolated a strain of the endophytic fungus Leucostoma persoonii from red mangrove, Rhizophora mangle [54] (Figure 10). Cytosporone B (33) demonstrated a 4.2-fold reduction in bacterial viability and at twice the MIC, resulted in complete killing of the bacteria. Furthermore, at MIC, a 2-fold reduction in biofilm formation was observed, and at twice the MIC, 168-fold reduction occurred. At higher concentrations, it appears strongly active toward biofilms, which is uncommon for antibiotics; however, cytosporone B is cytotoxic toward A549 cells (TI90 = IC90 A549/MIC90 = 6) [54]. Cytosporone E (34) was equipotent against USA100 and methicillin-sensitive S. aureus (MSSA) strains (72 μM), indicating the intrinsic drug resistant properties of MRSA strains are not helpful in resisting the action of this cytosporone. In addition, at MIC, it resulted in >5000-fold reduction in bacterial viability, indicating it is strongly bactericidal, and not just bacteriostatic. The cytosporone E MBC90 is significantly below its MIC, further demonstrating developmental potential. Cytosporone E is also cytotoxic, but reasonably selective for bacteria relative to mammalian cells (TI90 = 10). Cytosporone E (34), however, displayed an IC90 of 13 μM, which represents significant selectivity (TI90 = 33) for a moderately potent antimalarial drug [54].


Marine peptides and their anti-infective activities.

Kang HK, Seo CH, Park Y - Mar Drugs (2015)

Structure of cytosporomes B (33) and E (34). Cytosporomes were isolated a strain of the endophytic fungus Leucostoma persoonii [54].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306955&req=5

marinedrugs-13-00618-f010: Structure of cytosporomes B (33) and E (34). Cytosporomes were isolated a strain of the endophytic fungus Leucostoma persoonii [54].
Mentions: Cytosporomes B (33) and E (34) isolated a strain of the endophytic fungus Leucostoma persoonii from red mangrove, Rhizophora mangle [54] (Figure 10). Cytosporone B (33) demonstrated a 4.2-fold reduction in bacterial viability and at twice the MIC, resulted in complete killing of the bacteria. Furthermore, at MIC, a 2-fold reduction in biofilm formation was observed, and at twice the MIC, 168-fold reduction occurred. At higher concentrations, it appears strongly active toward biofilms, which is uncommon for antibiotics; however, cytosporone B is cytotoxic toward A549 cells (TI90 = IC90 A549/MIC90 = 6) [54]. Cytosporone E (34) was equipotent against USA100 and methicillin-sensitive S. aureus (MSSA) strains (72 μM), indicating the intrinsic drug resistant properties of MRSA strains are not helpful in resisting the action of this cytosporone. In addition, at MIC, it resulted in >5000-fold reduction in bacterial viability, indicating it is strongly bactericidal, and not just bacteriostatic. The cytosporone E MBC90 is significantly below its MIC, further demonstrating developmental potential. Cytosporone E is also cytotoxic, but reasonably selective for bacteria relative to mammalian cells (TI90 = 10). Cytosporone E (34), however, displayed an IC90 of 13 μM, which represents significant selectivity (TI90 = 33) for a moderately potent antimalarial drug [54].

Bottom Line: Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities.In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites.Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea. hkkang129@gmail.com.

ABSTRACT
Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present.

Show MeSH
Related in: MedlinePlus