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Marine peptides and their anti-infective activities.

Kang HK, Seo CH, Park Y - Mar Drugs (2015)

Bottom Line: Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities.In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites.Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea. hkkang129@gmail.com.

ABSTRACT
Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present.

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Structure of Cadiolides (29–32). Caldiolides were isolated from the tunicate Pseudodistoma antinboja by activity-guided fractionations [53].
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marinedrugs-13-00618-f009: Structure of Cadiolides (29–32). Caldiolides were isolated from the tunicate Pseudodistoma antinboja by activity-guided fractionations [53].

Mentions: Cadiolides C–F (29–32), butenolide metabolites (Figure 9), were isolated from the tunicate Pseudodistoma antinboja by activity-guided fractionations [53]. These compounds were evaluated for their antibacterial activity, and most of them exhibited moderate to significant activity that selectively targeted Gram-positive strains (S. aureus, S. epidermidis, Kocuria rhizophila and B. subtilis; MIC = 0.2–12.5 μg/mL). However, they did not show inhibitory activity toward the Gram-negative bacteria. Cadiolides C–F (29–32) was also showed antibacterial activities with methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) ranging from 0.13 to 4 μg/mL of MICs [53]. In addition, it should be noted that none of these compounds showed significant cytotoxicity in the MTT assay at 100 μM. Therefore, cadiolides could serve as new lead compounds for the development of antibiotics for the treatment of bacterial infections caused by Gram-positive bacteria, such as S. aureus [53].


Marine peptides and their anti-infective activities.

Kang HK, Seo CH, Park Y - Mar Drugs (2015)

Structure of Cadiolides (29–32). Caldiolides were isolated from the tunicate Pseudodistoma antinboja by activity-guided fractionations [53].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306955&req=5

marinedrugs-13-00618-f009: Structure of Cadiolides (29–32). Caldiolides were isolated from the tunicate Pseudodistoma antinboja by activity-guided fractionations [53].
Mentions: Cadiolides C–F (29–32), butenolide metabolites (Figure 9), were isolated from the tunicate Pseudodistoma antinboja by activity-guided fractionations [53]. These compounds were evaluated for their antibacterial activity, and most of them exhibited moderate to significant activity that selectively targeted Gram-positive strains (S. aureus, S. epidermidis, Kocuria rhizophila and B. subtilis; MIC = 0.2–12.5 μg/mL). However, they did not show inhibitory activity toward the Gram-negative bacteria. Cadiolides C–F (29–32) was also showed antibacterial activities with methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) ranging from 0.13 to 4 μg/mL of MICs [53]. In addition, it should be noted that none of these compounds showed significant cytotoxicity in the MTT assay at 100 μM. Therefore, cadiolides could serve as new lead compounds for the development of antibiotics for the treatment of bacterial infections caused by Gram-positive bacteria, such as S. aureus [53].

Bottom Line: Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities.In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites.Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea. hkkang129@gmail.com.

ABSTRACT
Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present.

Show MeSH
Related in: MedlinePlus