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Marine peptides and their anti-infective activities.

Kang HK, Seo CH, Park Y - Mar Drugs (2015)

Bottom Line: Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities.In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites.Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea. hkkang129@gmail.com.

ABSTRACT
Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present.

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Related in: MedlinePlus

Sequence alignment of three tilapia hepcidins (TH1-5, TH2-2, and TH2-3). Three hepcidins (4) were isolated from tilapia (Oreochromis mossambicus) [35]. Identical or similar amino acid residues are in same colors. Gaps are inserted to obtain maximum homology.
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marinedrugs-13-00618-f003: Sequence alignment of three tilapia hepcidins (TH1-5, TH2-2, and TH2-3). Three hepcidins (4) were isolated from tilapia (Oreochromis mossambicus) [35]. Identical or similar amino acid residues are in same colors. Gaps are inserted to obtain maximum homology.

Mentions: Hepcidins (4) are cysteine-rich peptides isolated from tilapia (Oreochromis mossambicus), with MICs (50–100 μg/mL) against L. monocytogenes, S. aureus, and Enterococcus faecium [35]. Hepcidins are antimicrobial peptides that play important roles in resisting pathogenic infection. Through hybridization of a phage library, the cDNA sequences of three hepcidin-like antimicrobial peptides (named TH1-5, TH2-2, and TH2-3) were identified in tilapia (Figure 3). The predicted molecular weights of TH1-5, TH2-2, and TH2-3 are 9.5, 9.4, and 9.8 kDa, respectively. Fish hepcidins are active against a wide variety of bacteria, both gram-positive and -negative in the low μM range, including potent activity against a large number of fish pathogens. In contrast, their quantified activity against fungi appears to be rather low [35].


Marine peptides and their anti-infective activities.

Kang HK, Seo CH, Park Y - Mar Drugs (2015)

Sequence alignment of three tilapia hepcidins (TH1-5, TH2-2, and TH2-3). Three hepcidins (4) were isolated from tilapia (Oreochromis mossambicus) [35]. Identical or similar amino acid residues are in same colors. Gaps are inserted to obtain maximum homology.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306955&req=5

marinedrugs-13-00618-f003: Sequence alignment of three tilapia hepcidins (TH1-5, TH2-2, and TH2-3). Three hepcidins (4) were isolated from tilapia (Oreochromis mossambicus) [35]. Identical or similar amino acid residues are in same colors. Gaps are inserted to obtain maximum homology.
Mentions: Hepcidins (4) are cysteine-rich peptides isolated from tilapia (Oreochromis mossambicus), with MICs (50–100 μg/mL) against L. monocytogenes, S. aureus, and Enterococcus faecium [35]. Hepcidins are antimicrobial peptides that play important roles in resisting pathogenic infection. Through hybridization of a phage library, the cDNA sequences of three hepcidin-like antimicrobial peptides (named TH1-5, TH2-2, and TH2-3) were identified in tilapia (Figure 3). The predicted molecular weights of TH1-5, TH2-2, and TH2-3 are 9.5, 9.4, and 9.8 kDa, respectively. Fish hepcidins are active against a wide variety of bacteria, both gram-positive and -negative in the low μM range, including potent activity against a large number of fish pathogens. In contrast, their quantified activity against fungi appears to be rather low [35].

Bottom Line: Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities.In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites.Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea. hkkang129@gmail.com.

ABSTRACT
Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present.

Show MeSH
Related in: MedlinePlus