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New meroterpenoids from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius.

Bai ZQ, Lin X, Wang J, Zhou X, Liu J, Yang B, Yang X, Liao S, Wang L, Liu Y - Mar Drugs (2015)

Bottom Line: Four new meroterpenoids (2-5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes.The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis.A possible biogenetic pathway of compounds 1-7 was also proposed.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. baizhiqiang10@mails.ucas.ac.cn.

ABSTRACT
Four new meroterpenoids (2-5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1-7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities.

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The chemical structures of compounds 1–7.
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marinedrugs-13-00237-f001: The chemical structures of compounds 1–7.

Mentions: In the course of our study on marine derived microbes, several active metabolites were isolated [13,14,15,16]. In our previous study, two aromatic butyrolactones were reported from the same fungus, A. flavipes [17]. In a continuing study, four new and three known meroterpenoids were isolated from the same fungus. Herein, the isolation, structural elucidation, biological activities, and plausible biogenetic pathway of compounds 1–7 are reported (Figure 1).


New meroterpenoids from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius.

Bai ZQ, Lin X, Wang J, Zhou X, Liu J, Yang B, Yang X, Liao S, Wang L, Liu Y - Mar Drugs (2015)

The chemical structures of compounds 1–7.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306934&req=5

marinedrugs-13-00237-f001: The chemical structures of compounds 1–7.
Mentions: In the course of our study on marine derived microbes, several active metabolites were isolated [13,14,15,16]. In our previous study, two aromatic butyrolactones were reported from the same fungus, A. flavipes [17]. In a continuing study, four new and three known meroterpenoids were isolated from the same fungus. Herein, the isolation, structural elucidation, biological activities, and plausible biogenetic pathway of compounds 1–7 are reported (Figure 1).

Bottom Line: Four new meroterpenoids (2-5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes.The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis.A possible biogenetic pathway of compounds 1-7 was also proposed.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. baizhiqiang10@mails.ucas.ac.cn.

ABSTRACT
Four new meroterpenoids (2-5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1-7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities.

Show MeSH