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Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012.

Hu Y, Chen J, Hu G, Yu J, Zhu X, Lin Y, Chen S, Yuan J - Mar Drugs (2015)

Bottom Line: This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products.We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress.We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development.

View Article: PubMed Central - PubMed

Affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education, Guangzhou 510080, China. hyw6@mail2.sysu.edu.cn.

ABSTRACT
Every year, hundreds of new compounds are discovered from the metabolites of marine organisms. Finding new and useful compounds is one of the crucial drivers for this field of research. Here we describe the statistics of bioactive compounds discovered from marine organisms from 1985 to 2012. This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products. We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress. We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development.

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Related in: MedlinePlus

Variation in the number and proportion of the eight bioactivity groups by year (* PHVD: Prevention of heart and vascular disease, ** PN/NT: Protection of neurons/neurotoxicity).
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marinedrugs-13-00202-f003: Variation in the number and proportion of the eight bioactivity groups by year (* PHVD: Prevention of heart and vascular disease, ** PN/NT: Protection of neurons/neurotoxicity).

Mentions: For clarity, we surveyed the percentage of each bioactivity group per year (Figure 3). The total number of bioactive compounds is also shown in Figure 3. Surprisingly, the fluctuations in the proportion of anticancer compounds are not consistent with the annual total number of bioactive compounds. In fact, it is the opposite. In most years, the total number of bioactive compounds negatively correlated with the proportion of anticancer compounds. Especially after 1990 this trend is more pronounced. As shown in Figure 3, in the bioactive compounds-rich years, there were more diverse bioactivity types and a higher number of other bioactive compounds that compressed the proportion of the anticancer group. For example, in 2008 there were more bioactive compounds with a relatively small proportion of antitumor activity. In 2006 or 2009, the situation was just the opposite. This may indicate that if we want to achieve more bioactive marine natural products, we should further develop other types of bioactivity tests beyond anticancer/cytotoxicity assays. However, it is certain that in the past 30 years, anticancer activity such as in vitro cytotoxicity tests played the dominant role in bioactivity research of novel marine compounds [49].


Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012.

Hu Y, Chen J, Hu G, Yu J, Zhu X, Lin Y, Chen S, Yuan J - Mar Drugs (2015)

Variation in the number and proportion of the eight bioactivity groups by year (* PHVD: Prevention of heart and vascular disease, ** PN/NT: Protection of neurons/neurotoxicity).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306932&req=5

marinedrugs-13-00202-f003: Variation in the number and proportion of the eight bioactivity groups by year (* PHVD: Prevention of heart and vascular disease, ** PN/NT: Protection of neurons/neurotoxicity).
Mentions: For clarity, we surveyed the percentage of each bioactivity group per year (Figure 3). The total number of bioactive compounds is also shown in Figure 3. Surprisingly, the fluctuations in the proportion of anticancer compounds are not consistent with the annual total number of bioactive compounds. In fact, it is the opposite. In most years, the total number of bioactive compounds negatively correlated with the proportion of anticancer compounds. Especially after 1990 this trend is more pronounced. As shown in Figure 3, in the bioactive compounds-rich years, there were more diverse bioactivity types and a higher number of other bioactive compounds that compressed the proportion of the anticancer group. For example, in 2008 there were more bioactive compounds with a relatively small proportion of antitumor activity. In 2006 or 2009, the situation was just the opposite. This may indicate that if we want to achieve more bioactive marine natural products, we should further develop other types of bioactivity tests beyond anticancer/cytotoxicity assays. However, it is certain that in the past 30 years, anticancer activity such as in vitro cytotoxicity tests played the dominant role in bioactivity research of novel marine compounds [49].

Bottom Line: This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products.We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress.We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development.

View Article: PubMed Central - PubMed

Affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education, Guangzhou 510080, China. hyw6@mail2.sysu.edu.cn.

ABSTRACT
Every year, hundreds of new compounds are discovered from the metabolites of marine organisms. Finding new and useful compounds is one of the crucial drivers for this field of research. Here we describe the statistics of bioactive compounds discovered from marine organisms from 1985 to 2012. This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products. We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress. We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development.

Show MeSH
Related in: MedlinePlus