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Effects of pectin lyase-modified red ginseng extracts in high-fat diet-fed obese mice.

Lee HY, Park KH, Park YM, Moon DI, Oh HG, Kwon DY, Yang HJ, Kim O, Kim DW, Yoo JH, Hong SC, Lee KH, Seol SY, Park YS, Park JD, Pyo MK - Lab Anim Res (2014)

Bottom Line: Treatment of GS-E3D reduced differentiation of 3T3-L1 adipocytes with low cytotoxicity.In the animal model, compared to the high fat diet control, serum glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TG, and leptin level were reduced in treatment animals in a dose-dependent manner.In addition, we found that GS-E3D could decrease total hepatic lipid droplets.

View Article: PubMed Central - PubMed

Affiliation: Huvet Co., Ltd., Iksan, Korea.

ABSTRACT
Red ginseng and its extracts have been used as traditional medicines and functional foods in countries worldwide. The aim of this study was to examine the bioavailability of pectin lyase-modified red ginseng extracts (GS-E3D), and the effects of GS-E3D on adipogenesis of 3T3-L1 adipocytes, as well as on metabolic disorders such as hyperglycemia, dyslipidemia, and fatty liver in high-fat diet fed obese C57BL/6 mice. Mice were divided into 5 groups: normal diet group, high fat diet-vehicle group, high fat diet + 0.1 g/kg GS-E3D (0.1-GS-E3D), high fat diet + 0.3 g/kg (0.3-GS-E3D), high fat diet + 1.0 g/kg (1.0-GS-E3D). Treatment of GS-E3D reduced differentiation of 3T3-L1 adipocytes with low cytotoxicity. In the animal model, compared to the high fat diet control, serum glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TG, and leptin level were reduced in treatment animals in a dose-dependent manner. In addition, we found that GS-E3D could decrease total hepatic lipid droplets. These results suggest that GS-E3D, as a dietary supplement, has beneficial effects on obesity and may have useful effects in health-care products.

No MeSH data available.


Related in: MedlinePlus

Effect of GS-E3D on the (A) body weight, (B) food and (C) water intake in the mice. *P<0.001 for high fat diet vs normal diet group. Data are shown as the mean±SE (n=8).
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Figure 4: Effect of GS-E3D on the (A) body weight, (B) food and (C) water intake in the mice. *P<0.001 for high fat diet vs normal diet group. Data are shown as the mean±SE (n=8).

Mentions: The effects of GS-E3D on body weights are shown in Figure 4A. After 4 weeks of treatment with GS-E3D, the body weight of the high fat diet-vehicle group was significantly higher than that of the normal group. In contrast, the body weights of the GS-E3D groups were significantly lower, compared to the high fat diet-vehicle group. Although the body weight was significantly reduced in the GS-E3D group at 4 weeks after supplementation, there were no significant observed differences in body weight from 1 to 3 weeks. However, food intake and water intake did not significantly differ between each group (Figures 4B and C).


Effects of pectin lyase-modified red ginseng extracts in high-fat diet-fed obese mice.

Lee HY, Park KH, Park YM, Moon DI, Oh HG, Kwon DY, Yang HJ, Kim O, Kim DW, Yoo JH, Hong SC, Lee KH, Seol SY, Park YS, Park JD, Pyo MK - Lab Anim Res (2014)

Effect of GS-E3D on the (A) body weight, (B) food and (C) water intake in the mice. *P<0.001 for high fat diet vs normal diet group. Data are shown as the mean±SE (n=8).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306702&req=5

Figure 4: Effect of GS-E3D on the (A) body weight, (B) food and (C) water intake in the mice. *P<0.001 for high fat diet vs normal diet group. Data are shown as the mean±SE (n=8).
Mentions: The effects of GS-E3D on body weights are shown in Figure 4A. After 4 weeks of treatment with GS-E3D, the body weight of the high fat diet-vehicle group was significantly higher than that of the normal group. In contrast, the body weights of the GS-E3D groups were significantly lower, compared to the high fat diet-vehicle group. Although the body weight was significantly reduced in the GS-E3D group at 4 weeks after supplementation, there were no significant observed differences in body weight from 1 to 3 weeks. However, food intake and water intake did not significantly differ between each group (Figures 4B and C).

Bottom Line: Treatment of GS-E3D reduced differentiation of 3T3-L1 adipocytes with low cytotoxicity.In the animal model, compared to the high fat diet control, serum glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TG, and leptin level were reduced in treatment animals in a dose-dependent manner.In addition, we found that GS-E3D could decrease total hepatic lipid droplets.

View Article: PubMed Central - PubMed

Affiliation: Huvet Co., Ltd., Iksan, Korea.

ABSTRACT
Red ginseng and its extracts have been used as traditional medicines and functional foods in countries worldwide. The aim of this study was to examine the bioavailability of pectin lyase-modified red ginseng extracts (GS-E3D), and the effects of GS-E3D on adipogenesis of 3T3-L1 adipocytes, as well as on metabolic disorders such as hyperglycemia, dyslipidemia, and fatty liver in high-fat diet fed obese C57BL/6 mice. Mice were divided into 5 groups: normal diet group, high fat diet-vehicle group, high fat diet + 0.1 g/kg GS-E3D (0.1-GS-E3D), high fat diet + 0.3 g/kg (0.3-GS-E3D), high fat diet + 1.0 g/kg (1.0-GS-E3D). Treatment of GS-E3D reduced differentiation of 3T3-L1 adipocytes with low cytotoxicity. In the animal model, compared to the high fat diet control, serum glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TG, and leptin level were reduced in treatment animals in a dose-dependent manner. In addition, we found that GS-E3D could decrease total hepatic lipid droplets. These results suggest that GS-E3D, as a dietary supplement, has beneficial effects on obesity and may have useful effects in health-care products.

No MeSH data available.


Related in: MedlinePlus