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Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study.

Kawada C, Yoshida T, Yoshida H, Sakamoto W, Odanaka W, Sato T, Yamasaki T, Kanemitsu T, Masuda Y, Urushibata O - J Clin Biochem Nutr (2014)

Bottom Line: However, the effect of ingested HA may depend on its molecular weight (MW) because its physiological activities in the body vary with its MW.A questionnaire survey about subjective facial aging symptoms showed that the HA treated groups exhibited significantly improved the skin condition compared with the placebo treated group.This study shows that both of ingesting HAs (MWs 800 k and 300 k) improved the skin condition by increasing the moisture content.

View Article: PubMed Central - PubMed

Affiliation: R&D Division, Kewpie Corporation, 2-5-7 Sengawa-cho, Chofu-shi, Tokyo 182-0002, Japan.

ABSTRACT
Hyaluronan (HA) has been increasingly used as a dietary supplement to improve the skin. However, the effect of ingested HA may depend on its molecular weight (MW) because its physiological activities in the body vary with its MW. In this study, we examined the effects of ingested HA with varying MW on the skin. In this randomized, double blind, placebo controlled study, 61 subjects with dry skin received oral HA (120 mg/day), of MWs 800 k and 300 k or placebo, for 6 weeks. The skin moisture contents of the first two groups increased more than those of the placebo group during the ingestion period. In addition, group HA 300 k exhibited significant improvements in skin moisture content 2 weeks after ingestion ended compared with the placebo group. A questionnaire survey about subjective facial aging symptoms showed that the HA treated groups exhibited significantly improved the skin condition compared with the placebo treated group. Furthermore, dermatologists objectively evaluated the clinical symptoms of the facial and whole body skin, showing that no adverse events were related to daily ingestion of HA. This study shows that both of ingesting HAs (MWs 800 k and 300 k) improved the skin condition by increasing the moisture content.

No MeSH data available.


Related in: MedlinePlus

Changes in the skin wrinkles with time score after the ingestion of hyaluronans and the placebo. A questionnaire was completed to evaluate the subjective skin wrinkles prior to ingestion, 3 and 6 weeks of ingestion, and 2 weeks after ingestion ended. The number of answers for each score is indicated in the histogram: (A) prior to ingestion, (B) 3 weeks of ingestion, (C) 6 weeks of ingestion, and (D) 2 weeks after ingestion ended.
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Related In: Results  -  Collection


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Figure 6: Changes in the skin wrinkles with time score after the ingestion of hyaluronans and the placebo. A questionnaire was completed to evaluate the subjective skin wrinkles prior to ingestion, 3 and 6 weeks of ingestion, and 2 weeks after ingestion ended. The number of answers for each score is indicated in the histogram: (A) prior to ingestion, (B) 3 weeks of ingestion, (C) 6 weeks of ingestion, and (D) 2 weeks after ingestion ended.

Mentions: The effects of HA on the subjective symptoms of facial skin aging, i.e., luster, suppleness, and wrinkles, were evaluated using a questionnaire. The luster and suppleness were improved significantly in the HA treated groups than in the placebo-treated group (Fig. 3, 4, 5, 6).


Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study.

Kawada C, Yoshida T, Yoshida H, Sakamoto W, Odanaka W, Sato T, Yamasaki T, Kanemitsu T, Masuda Y, Urushibata O - J Clin Biochem Nutr (2014)

Changes in the skin wrinkles with time score after the ingestion of hyaluronans and the placebo. A questionnaire was completed to evaluate the subjective skin wrinkles prior to ingestion, 3 and 6 weeks of ingestion, and 2 weeks after ingestion ended. The number of answers for each score is indicated in the histogram: (A) prior to ingestion, (B) 3 weeks of ingestion, (C) 6 weeks of ingestion, and (D) 2 weeks after ingestion ended.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4306664&req=5

Figure 6: Changes in the skin wrinkles with time score after the ingestion of hyaluronans and the placebo. A questionnaire was completed to evaluate the subjective skin wrinkles prior to ingestion, 3 and 6 weeks of ingestion, and 2 weeks after ingestion ended. The number of answers for each score is indicated in the histogram: (A) prior to ingestion, (B) 3 weeks of ingestion, (C) 6 weeks of ingestion, and (D) 2 weeks after ingestion ended.
Mentions: The effects of HA on the subjective symptoms of facial skin aging, i.e., luster, suppleness, and wrinkles, were evaluated using a questionnaire. The luster and suppleness were improved significantly in the HA treated groups than in the placebo-treated group (Fig. 3, 4, 5, 6).

Bottom Line: However, the effect of ingested HA may depend on its molecular weight (MW) because its physiological activities in the body vary with its MW.A questionnaire survey about subjective facial aging symptoms showed that the HA treated groups exhibited significantly improved the skin condition compared with the placebo treated group.This study shows that both of ingesting HAs (MWs 800 k and 300 k) improved the skin condition by increasing the moisture content.

View Article: PubMed Central - PubMed

Affiliation: R&D Division, Kewpie Corporation, 2-5-7 Sengawa-cho, Chofu-shi, Tokyo 182-0002, Japan.

ABSTRACT
Hyaluronan (HA) has been increasingly used as a dietary supplement to improve the skin. However, the effect of ingested HA may depend on its molecular weight (MW) because its physiological activities in the body vary with its MW. In this study, we examined the effects of ingested HA with varying MW on the skin. In this randomized, double blind, placebo controlled study, 61 subjects with dry skin received oral HA (120 mg/day), of MWs 800 k and 300 k or placebo, for 6 weeks. The skin moisture contents of the first two groups increased more than those of the placebo group during the ingestion period. In addition, group HA 300 k exhibited significant improvements in skin moisture content 2 weeks after ingestion ended compared with the placebo group. A questionnaire survey about subjective facial aging symptoms showed that the HA treated groups exhibited significantly improved the skin condition compared with the placebo treated group. Furthermore, dermatologists objectively evaluated the clinical symptoms of the facial and whole body skin, showing that no adverse events were related to daily ingestion of HA. This study shows that both of ingesting HAs (MWs 800 k and 300 k) improved the skin condition by increasing the moisture content.

No MeSH data available.


Related in: MedlinePlus