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Intestinal Peyer's patches prevent tumorigenesis in Apc (Min/+) mice.

Fujimoto K, Fujii G, Sakurai H, Yoshitome H, Mutoh M, Wada M - J Clin Biochem Nutr (2014)

Bottom Line: Using this model, we increased the number of Peyer's patches using 0.1% and 1% corn husk arabinoxylan through feed.Immune reaction following corn husk arabinoxylan treatment was measured by cytokine array.Increasing the number of Peyer's patches decreased interleukin-17 production, which showed a dose dependent correlation with transcription factor/lymphoid enhancer-binding factor.

View Article: PubMed Central - PubMed

Affiliation: Division of Molecular Biology, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo-shi, Nagasaki 859-3298, Japan.

ABSTRACT
Peyer's patches are nodules that play a central role in intestinal immunity. Few studies demonstrate the relationship between the number of Peyer's patches and intestinal polyps. Here we identify a statistically significant inverse correlation between the quantity of Peyer's patches and of the development of intestinal polyps in Apc (Min/+) mice, which are a useful model to clarify the role of Peyer's patches in intestinal tumorigenesis. Using this model, we increased the number of Peyer's patches using 0.1% and 1% corn husk arabinoxylan through feed. Intestinal polyp formation significantly decreased, concomitant with an increase in Peyer's patches development (n = 12/group). In Aly (-/-) Apc (Min/+) mice (negative control; no Peyer's patches) there was no change in the amount of intestinal polyps (n = 10/group). Immune reaction following corn husk arabinoxylan treatment was measured by cytokine array. Increasing the number of Peyer's patches decreased interleukin-17 production, which showed a dose dependent correlation with transcription factor/lymphoid enhancer-binding factor. This study identified a relationship between levels of Peyer's patches and intestinal polyp formation, partly explained by the involvement of interleukin-17 production and β-catenin signaling in Apc (Min/+) mice.

No MeSH data available.


Related in: MedlinePlus

The correlation between the number of intestinal polyps and Peyer’s Patches (r = –0.62, n = 20, p = 0.0035).
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Figure 1: The correlation between the number of intestinal polyps and Peyer’s Patches (r = –0.62, n = 20, p = 0.0035).

Mentions: We counted the number of intestinal polyps and PP in ApcMin/+ mice >24 weeks in age. Mice that developed many intestinal polyps tended to have been fewer PP in the intestine. A statistically significant inverse relationship existed between the number of intestinal polyps and PP (r = −0.62, n = 20, p = 0.0035; Fig. 1). In addition, the amount of PP in the intestines decreased in older mice groups (Fig. 2). The quantity of PP in the intestines was significantly reduced in ApcMin/+ mice >21 weeks of age compared with 12-week-old ApcMin/+ mice. Moreover, the number of polyps significantly increased in older mice groups.


Intestinal Peyer's patches prevent tumorigenesis in Apc (Min/+) mice.

Fujimoto K, Fujii G, Sakurai H, Yoshitome H, Mutoh M, Wada M - J Clin Biochem Nutr (2014)

The correlation between the number of intestinal polyps and Peyer’s Patches (r = –0.62, n = 20, p = 0.0035).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4306656&req=5

Figure 1: The correlation between the number of intestinal polyps and Peyer’s Patches (r = –0.62, n = 20, p = 0.0035).
Mentions: We counted the number of intestinal polyps and PP in ApcMin/+ mice >24 weeks in age. Mice that developed many intestinal polyps tended to have been fewer PP in the intestine. A statistically significant inverse relationship existed between the number of intestinal polyps and PP (r = −0.62, n = 20, p = 0.0035; Fig. 1). In addition, the amount of PP in the intestines decreased in older mice groups (Fig. 2). The quantity of PP in the intestines was significantly reduced in ApcMin/+ mice >21 weeks of age compared with 12-week-old ApcMin/+ mice. Moreover, the number of polyps significantly increased in older mice groups.

Bottom Line: Using this model, we increased the number of Peyer's patches using 0.1% and 1% corn husk arabinoxylan through feed.Immune reaction following corn husk arabinoxylan treatment was measured by cytokine array.Increasing the number of Peyer's patches decreased interleukin-17 production, which showed a dose dependent correlation with transcription factor/lymphoid enhancer-binding factor.

View Article: PubMed Central - PubMed

Affiliation: Division of Molecular Biology, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo-shi, Nagasaki 859-3298, Japan.

ABSTRACT
Peyer's patches are nodules that play a central role in intestinal immunity. Few studies demonstrate the relationship between the number of Peyer's patches and intestinal polyps. Here we identify a statistically significant inverse correlation between the quantity of Peyer's patches and of the development of intestinal polyps in Apc (Min/+) mice, which are a useful model to clarify the role of Peyer's patches in intestinal tumorigenesis. Using this model, we increased the number of Peyer's patches using 0.1% and 1% corn husk arabinoxylan through feed. Intestinal polyp formation significantly decreased, concomitant with an increase in Peyer's patches development (n = 12/group). In Aly (-/-) Apc (Min/+) mice (negative control; no Peyer's patches) there was no change in the amount of intestinal polyps (n = 10/group). Immune reaction following corn husk arabinoxylan treatment was measured by cytokine array. Increasing the number of Peyer's patches decreased interleukin-17 production, which showed a dose dependent correlation with transcription factor/lymphoid enhancer-binding factor. This study identified a relationship between levels of Peyer's patches and intestinal polyp formation, partly explained by the involvement of interleukin-17 production and β-catenin signaling in Apc (Min/+) mice.

No MeSH data available.


Related in: MedlinePlus