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White matter ischemic changes in hyperacute ischemic stroke: voxel-based analysis using diffusion tensor imaging and MR perfusion.

Nael K, Trouard TP, Lafleur SR, Krupinski EA, Salamon N, Kidwell CS - Stroke (2014)

Bottom Line: There was an overall significant mean difference (P<0.001) for the apparent diffusion coefficient, Tmax, and FA values between the normal, hypoperfused, and infarcted WM.The mean±SD of FA was significantly higher (P<0.001) in hypoperfused WM (0.397±0.019) and lower (P<0.001) in infarcted WM (0.313±0.037) when compared with normal WM (0.360±0.020).The significantly increased FA values in the hypoperfused WM with Tmax≥5.4 s are suggestive of early ischemic microstructural changes.

View Article: PubMed Central - PubMed

Affiliation: From the Departments of Medical Imaging (K.N., T.P.T., E.A.K., C.S.K.), Biomedical Engineering (T.P.T., S.R.L., E.A.K.), Neurology (C.S.K.), University of Arizona, Tucson; and Department of Radiology, University of California, Los Angeles (N.S.). Kambiznael@gmail.com.

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Scatter plots for fractional anisotropy (FA), Tmax, and apparent diffusion coefficient (ADC) mean values by region. The correlation pattern is different depending on the region. In the normal white matter (WM), FA, and ADC have a moderate negative correlation (rs=−0.590; P=0.005). In the hypoperfused WM, Tmax and FA have moderate positive correlation (rs=0.561; P=0.008). In the infarcted WM, there are moderate negative correlations between Tmax and FA (rs=−0.539; P=0.012) and Tmax and ADC (rs=−0.681; P<0.001).
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Figure 2: Scatter plots for fractional anisotropy (FA), Tmax, and apparent diffusion coefficient (ADC) mean values by region. The correlation pattern is different depending on the region. In the normal white matter (WM), FA, and ADC have a moderate negative correlation (rs=−0.590; P=0.005). In the hypoperfused WM, Tmax and FA have moderate positive correlation (rs=0.561; P=0.008). In the infarcted WM, there are moderate negative correlations between Tmax and FA (rs=−0.539; P=0.012) and Tmax and ADC (rs=−0.681; P<0.001).

Mentions: Scatter plots for association between ADC, FA, and Tmax in normal, hypoperfused, and infarcted WM are shown in Figure 2. Spearman correlations (rs) for association between ADC-FA, ADC-Tmax, and FA-Tmax were −0.590, −0.021, and 0.418 in normal WM; −0.230, 0.319, and 0.561 in hypoperfused WM, and 0.209, −0.681, and −0.539 in infarcted WM, respectively.


White matter ischemic changes in hyperacute ischemic stroke: voxel-based analysis using diffusion tensor imaging and MR perfusion.

Nael K, Trouard TP, Lafleur SR, Krupinski EA, Salamon N, Kidwell CS - Stroke (2014)

Scatter plots for fractional anisotropy (FA), Tmax, and apparent diffusion coefficient (ADC) mean values by region. The correlation pattern is different depending on the region. In the normal white matter (WM), FA, and ADC have a moderate negative correlation (rs=−0.590; P=0.005). In the hypoperfused WM, Tmax and FA have moderate positive correlation (rs=0.561; P=0.008). In the infarcted WM, there are moderate negative correlations between Tmax and FA (rs=−0.539; P=0.012) and Tmax and ADC (rs=−0.681; P<0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306535&req=5

Figure 2: Scatter plots for fractional anisotropy (FA), Tmax, and apparent diffusion coefficient (ADC) mean values by region. The correlation pattern is different depending on the region. In the normal white matter (WM), FA, and ADC have a moderate negative correlation (rs=−0.590; P=0.005). In the hypoperfused WM, Tmax and FA have moderate positive correlation (rs=0.561; P=0.008). In the infarcted WM, there are moderate negative correlations between Tmax and FA (rs=−0.539; P=0.012) and Tmax and ADC (rs=−0.681; P<0.001).
Mentions: Scatter plots for association between ADC, FA, and Tmax in normal, hypoperfused, and infarcted WM are shown in Figure 2. Spearman correlations (rs) for association between ADC-FA, ADC-Tmax, and FA-Tmax were −0.590, −0.021, and 0.418 in normal WM; −0.230, 0.319, and 0.561 in hypoperfused WM, and 0.209, −0.681, and −0.539 in infarcted WM, respectively.

Bottom Line: There was an overall significant mean difference (P<0.001) for the apparent diffusion coefficient, Tmax, and FA values between the normal, hypoperfused, and infarcted WM.The mean±SD of FA was significantly higher (P<0.001) in hypoperfused WM (0.397±0.019) and lower (P<0.001) in infarcted WM (0.313±0.037) when compared with normal WM (0.360±0.020).The significantly increased FA values in the hypoperfused WM with Tmax≥5.4 s are suggestive of early ischemic microstructural changes.

View Article: PubMed Central - PubMed

Affiliation: From the Departments of Medical Imaging (K.N., T.P.T., E.A.K., C.S.K.), Biomedical Engineering (T.P.T., S.R.L., E.A.K.), Neurology (C.S.K.), University of Arizona, Tucson; and Department of Radiology, University of California, Los Angeles (N.S.). Kambiznael@gmail.com.

Show MeSH
Related in: MedlinePlus