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25-Hydroxyvitamin D Supplementation and BMI Change: A Meta-Analysis of Randomized Controlled Trials.

Mora N, Rieke K, Plitcha J, Segura A, Leehey D, DeShong K, Kramer H, Durazo-Arvizu RA - J Obes Weight Loss Ther (2013)

Bottom Line: Total participants included 1651 adults (82.6% women and mean age 47.9 years) and mean follow-up ranged between 6 to 196 weeks and mean daily 25[OH]D dose ranged from 200 IU to 1,110 IU.Five of the 9 studies included calcium supplementation in both groups.Five studies suggested a beneficial effect for 25[OH]D supplementation for BMI change whereas 3 studies showed no effect of 25[OH]D supplementation on BMI change, and one showed a non-perceptible change.

View Article: PubMed Central - HTML - PubMed

Affiliation: Public Health Program, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA.

ABSTRACT

The impact of 25-hydroxyvitamin D (25[OH]D) supplementation on weight change remains controversial. The objective of this study was to summarize the effects of 25[OH]D supplementation (cholecalciferol or ergocalciferol) on BMI change through a meta-analysis of published clinical trials. We completed a systematic review of English articles, using MEDLINE (Ovid, Pubmed) from January 1, 1998 through January 1, 2013. The articles selected focused on 25[OH]D supplementation and body mass index (BMI) in randomized controlled trials (RCT's). The association between 25[OH]D and mean BMI change was estimated utilizing a random effects model. A total of 30 studies were reviewed and 9 were included in the meta-analysis. Total participants included 1651 adults (82.6% women and mean age 47.9 years) and mean follow-up ranged between 6 to 196 weeks and mean daily 25[OH]D dose ranged from 200 IU to 1,110 IU. Five of the 9 studies included calcium supplementation in both groups. Average baseline BMI was 30.7 and 30.4 kg/m(2) in the intervention and control groups, respectively. Five studies suggested a beneficial effect for 25[OH]D supplementation for BMI change whereas 3 studies showed no effect of 25[OH]D supplementation on BMI change, and one showed a non-perceptible change. Meta-analysis of BMI values at end of trial showed no statistically significant difference in BMI change by use of 25[OH]D supplementation. Based on existing published trials, oral 25[OH]D supplementation does not significantly impact BMI change.

No MeSH data available.


Egger plot to assess publication bias in the association between change in BMI and vitamin D supplementation.
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Figure 4: Egger plot to assess publication bias in the association between change in BMI and vitamin D supplementation.

Mentions: Meta-analysis showed no statistically significant differences in BMI change by use of 25[OH]D supplementation (p value=0.8). The I2 showed that 0% of the effect of variance in dispersion in the true effects, and the T2 reflected no heterogeneity between studies on the absolute scale. Figure 3 displays the funnel plots which suggested no evidence of publication bias. The test of Begg and Mazumdar, and of Egger suggested no publication bias, both with a p value of 0.18 (Figure 4).


25-Hydroxyvitamin D Supplementation and BMI Change: A Meta-Analysis of Randomized Controlled Trials.

Mora N, Rieke K, Plitcha J, Segura A, Leehey D, DeShong K, Kramer H, Durazo-Arvizu RA - J Obes Weight Loss Ther (2013)

Egger plot to assess publication bias in the association between change in BMI and vitamin D supplementation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4306432&req=5

Figure 4: Egger plot to assess publication bias in the association between change in BMI and vitamin D supplementation.
Mentions: Meta-analysis showed no statistically significant differences in BMI change by use of 25[OH]D supplementation (p value=0.8). The I2 showed that 0% of the effect of variance in dispersion in the true effects, and the T2 reflected no heterogeneity between studies on the absolute scale. Figure 3 displays the funnel plots which suggested no evidence of publication bias. The test of Begg and Mazumdar, and of Egger suggested no publication bias, both with a p value of 0.18 (Figure 4).

Bottom Line: Total participants included 1651 adults (82.6% women and mean age 47.9 years) and mean follow-up ranged between 6 to 196 weeks and mean daily 25[OH]D dose ranged from 200 IU to 1,110 IU.Five of the 9 studies included calcium supplementation in both groups.Five studies suggested a beneficial effect for 25[OH]D supplementation for BMI change whereas 3 studies showed no effect of 25[OH]D supplementation on BMI change, and one showed a non-perceptible change.

View Article: PubMed Central - HTML - PubMed

Affiliation: Public Health Program, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA.

ABSTRACT

The impact of 25-hydroxyvitamin D (25[OH]D) supplementation on weight change remains controversial. The objective of this study was to summarize the effects of 25[OH]D supplementation (cholecalciferol or ergocalciferol) on BMI change through a meta-analysis of published clinical trials. We completed a systematic review of English articles, using MEDLINE (Ovid, Pubmed) from January 1, 1998 through January 1, 2013. The articles selected focused on 25[OH]D supplementation and body mass index (BMI) in randomized controlled trials (RCT's). The association between 25[OH]D and mean BMI change was estimated utilizing a random effects model. A total of 30 studies were reviewed and 9 were included in the meta-analysis. Total participants included 1651 adults (82.6% women and mean age 47.9 years) and mean follow-up ranged between 6 to 196 weeks and mean daily 25[OH]D dose ranged from 200 IU to 1,110 IU. Five of the 9 studies included calcium supplementation in both groups. Average baseline BMI was 30.7 and 30.4 kg/m(2) in the intervention and control groups, respectively. Five studies suggested a beneficial effect for 25[OH]D supplementation for BMI change whereas 3 studies showed no effect of 25[OH]D supplementation on BMI change, and one showed a non-perceptible change. Meta-analysis of BMI values at end of trial showed no statistically significant difference in BMI change by use of 25[OH]D supplementation. Based on existing published trials, oral 25[OH]D supplementation does not significantly impact BMI change.

No MeSH data available.