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Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome.

Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM - J Lipids (2015)

Bottom Line: The fruits extract of bitter melon showed strong antioxidant and hypoglycemic activities in experimental condition both in vivo and in vitro.These beneficial effects are mediated probably by inducing lipid and fat metabolizing gene expression and increasing the function of AMPK and PPARs, and so forth.This review will thus focus on the recent findings on beneficial effect of Momordica charantia extracts on metabolic syndrome and discuss its potential mechanism of actions.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.

ABSTRACT
Diabetes, obesity, and metabolic syndrome are becoming epidemic both in developed and developing countries in recent years. Complementary and alternative medicines have been used since ancient era for the treatment of diabetes and cardiovascular diseases. Bitter melon is widely used as vegetables in daily food in Bangladesh and several other countries in Asia. The fruits extract of bitter melon showed strong antioxidant and hypoglycemic activities in experimental condition both in vivo and in vitro. Recent scientific evaluation of this plant extracts also showed potential therapeutic benefit in diabetes and obesity related metabolic dysfunction in experimental animals and clinical studies. These beneficial effects are mediated probably by inducing lipid and fat metabolizing gene expression and increasing the function of AMPK and PPARs, and so forth. This review will thus focus on the recent findings on beneficial effect of Momordica charantia extracts on metabolic syndrome and discuss its potential mechanism of actions.

No MeSH data available.


Related in: MedlinePlus

Effect of bitter melon on various organ and probable molecular targets for improving obesity and diabetes.
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Related In: Results  -  Collection


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fig5: Effect of bitter melon on various organ and probable molecular targets for improving obesity and diabetes.

Mentions: Body weight gain and abdominal fat deposition are the early signs of obesity. Bitter melon extract showed useful benefit on body weight gain and fat deposition (Figure 5, Table 1). Several investigational reports suggest that bitter melon can reduce body weight in high fat diet induced obesity in laboratory animals. Bitter melon (0.75% of diet) supplementation prevented the body weight gain and visceral fat mass significantly in rats fed high fat diet [58]. This weight reduction may be a result of increased fatty acid oxidation which ultimately facilitates weight reduction [58]. Moreover, the bitter melon extract supplementation reduced the peritoneal fat deposition in rats fed a high fat diet [58]. In another study, bitter melon significantly decreased the weights of epididymal white adipose tissue (WAT), visceral fat, and the adipose leptin and resistin mRNA levels in C57BL/6J mice fed with a high-fat (HF) diet [59]. Bano et al. reported that 2 mL/day dose of aqueous extract of bitter melon significantly reduced body weight gain in rats [60]. A recent study also showed that the seed oil supplementation of the plant reduced body weight and fat mass in mice fed a high fat diet [61].


Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome.

Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM - J Lipids (2015)

Effect of bitter melon on various organ and probable molecular targets for improving obesity and diabetes.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4306384&req=5

fig5: Effect of bitter melon on various organ and probable molecular targets for improving obesity and diabetes.
Mentions: Body weight gain and abdominal fat deposition are the early signs of obesity. Bitter melon extract showed useful benefit on body weight gain and fat deposition (Figure 5, Table 1). Several investigational reports suggest that bitter melon can reduce body weight in high fat diet induced obesity in laboratory animals. Bitter melon (0.75% of diet) supplementation prevented the body weight gain and visceral fat mass significantly in rats fed high fat diet [58]. This weight reduction may be a result of increased fatty acid oxidation which ultimately facilitates weight reduction [58]. Moreover, the bitter melon extract supplementation reduced the peritoneal fat deposition in rats fed a high fat diet [58]. In another study, bitter melon significantly decreased the weights of epididymal white adipose tissue (WAT), visceral fat, and the adipose leptin and resistin mRNA levels in C57BL/6J mice fed with a high-fat (HF) diet [59]. Bano et al. reported that 2 mL/day dose of aqueous extract of bitter melon significantly reduced body weight gain in rats [60]. A recent study also showed that the seed oil supplementation of the plant reduced body weight and fat mass in mice fed a high fat diet [61].

Bottom Line: The fruits extract of bitter melon showed strong antioxidant and hypoglycemic activities in experimental condition both in vivo and in vitro.These beneficial effects are mediated probably by inducing lipid and fat metabolizing gene expression and increasing the function of AMPK and PPARs, and so forth.This review will thus focus on the recent findings on beneficial effect of Momordica charantia extracts on metabolic syndrome and discuss its potential mechanism of actions.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.

ABSTRACT
Diabetes, obesity, and metabolic syndrome are becoming epidemic both in developed and developing countries in recent years. Complementary and alternative medicines have been used since ancient era for the treatment of diabetes and cardiovascular diseases. Bitter melon is widely used as vegetables in daily food in Bangladesh and several other countries in Asia. The fruits extract of bitter melon showed strong antioxidant and hypoglycemic activities in experimental condition both in vivo and in vitro. Recent scientific evaluation of this plant extracts also showed potential therapeutic benefit in diabetes and obesity related metabolic dysfunction in experimental animals and clinical studies. These beneficial effects are mediated probably by inducing lipid and fat metabolizing gene expression and increasing the function of AMPK and PPARs, and so forth. This review will thus focus on the recent findings on beneficial effect of Momordica charantia extracts on metabolic syndrome and discuss its potential mechanism of actions.

No MeSH data available.


Related in: MedlinePlus